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GENE：COPZ1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COPZ1
FullNmae COPI coat complex subunit zeta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2243
EnsembleID ENSG00000111481
Uniprot P61923

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COPZ1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COPZ1 GO:0000139,GO:0005789,GO:0005829,GO:0006886,GO:0006890,GO:0006890,GO:0006891,GO:0006891,GO:0006891,GO:0030126,GO:0030126,GO:0030126,GO:0030133

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR COPZ1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 COPZ1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 COPZ1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 COPZ1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 COPZ1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 COPZ1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 COPZ1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR COPZ1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000BE495 COPZ1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002004E0 COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A COPZ1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000279B6F COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001B341F COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000330617 COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001799A3 COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000030F801 COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E5ECC COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019D79B COPZ1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
COPB1 COPZ1 25361965 interaction type N/A PTMCode2
COPZ1 COPB1 25361965 interaction type N/A PTMCode2
COPZ1 ARCN1 25361965 interaction type N/A PTMCode2
ARCN1 COPZ1 25361965 interaction type N/A PTMCode2
COPZ1 COPA 25361965 interaction type N/A PTMCode2
COPA COPZ1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EIF1B COPZ1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SH3GLB1 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DRG1 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BAG3 COPZ1 25348397 N/A physical interaction ComPPI
KEAP1 COPZ1 25348397 N/A physical interaction ComPPI
TLE3 COPZ1 25348397 N/A physical interaction ComPPI
SF3B1 COPZ1 25348397 N/A physical interaction ComPPI
SCYL2 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DLD COPZ1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COPB1 COPZ1 18356299 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COPA COPZ1 25348397 N/A physical interaction ComPPI
DIAPH1 COPZ1 25348397 N/A physical interaction ComPPI
SUB1 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DUSP1 COPZ1 25348397 N/A physical interaction ComPPI
COPB2 COPZ1 25348397 N/A physical interaction ComPPI
RUFY1 COPZ1 25348397 N/A physical interaction ComPPI
XPO1 COPZ1 25348397 N/A physical interaction ComPPI
KLC1 COPZ1 25348397 N/A physical interaction ComPPI
CDK5 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRIM25 COPZ1 25348397 N/A physical interaction ComPPI
GOPC COPZ1 25348397 N/A physical interaction ComPPI
ARCN1 COPZ1 25348397 N/A physical interaction ComPPI
COPG2 COPZ1 11056392 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
COPG1 COPZ1 11056392 14525934 18356299 24234451 25348397 association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
DTNBP1 COPZ1 25348397 N/A physical interaction ComPPI
DIS3 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SEPTIN7 COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COPZ1 TMED10 25348397 N/A physical interaction ComPPI
COPZ1 APP 25348397 N/A physical interaction ComPPI
COPZ1 TMED9 25348397 N/A physical interaction ComPPI
COPZ1 UGT1A1 25348397 N/A physical interaction ComPPI
COPZ1 COA8 25348397 N/A physical interaction ComPPI
COPZ1 TTI1 25348397 N/A physical interaction ComPPI
COPZ1 NUDCD1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COPZ1 STAU1 25348397 N/A physical interaction ComPPI
COPZ1 HERC2 25348397 N/A physical interaction ComPPI
COPZ1 HERC2P3 25348397 N/A physical interaction ComPPI
COPZ1 MKS1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COPZ1 DUSP28 25348397 N/A physical interaction ComPPI
COPZ1 DUSP8 25348397 N/A physical interaction ComPPI
COPZ1 CHORDC1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COPZ1 PRCC 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COPZ1 ZC3HAV1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
COPZ1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COPZ1 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COPZ1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
SARNP COPZ1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct

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