Gene Information gene info

GENE:COX11

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX11
FullNmae cytochrome c oxidase copper chaperone COX11
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2261
EnsembleID ENSG00000166260
Uniprot Q9Y6N1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX11 cuproptosis 37979442 Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. Cu chaperones
COX11 cuproptosis 38339398 Cytochrome C Oxidase Copper Chaperone (COX11):Delivers copper to COX1 copper ionophores
COX11 cuproptosis 38006800 Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C–C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. cuproptosis-related genes
COX11 cuproptosis 38006800 COX11 is reported to the regulation of copper ions in diabetes-induced heart failure disease models. regulator
COX11 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
COX11 cuproptosis 38348451 COX11 involved in copper delivery to cytochrome c oxidase and are crucial for mitochondrial function. CRGs in the cuproptosis pathway
COX11 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
COX11 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
COX11 cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
COX11 cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COX11 GO:0005507,GO:0005515,GO:0005739,GO:0005743,GO:0006754,GO:0009055,GO:0022900,GO:0030003,GO:0032991

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX11 hsa:1353 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX11 hsa:1353 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX11 hsa:1353 path:hsa04714 Thermogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR COX11 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 COX11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COX11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 COX11 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COX11 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
ERCC3 COX11 25348397 N/A physical interaction ComPPI
PTPN1 COX11 25348397 N/A physical interaction ComPPI
SQSTM1 COX11 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
MTNR1A COX11 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
KLK5 COX11 25348397 N/A physical interaction ComPPI
MTNR1B COX11 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
COX6B1 COX11 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
RPL19 COX11 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NDUFA4 COX11 25348397 N/A physical interaction ComPPI
COX11 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

Visualization