GENE:COX11
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | COX11 |
FullNmae | cytochrome c oxidase copper chaperone COX11 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:2261 |
EnsembleID | ENSG00000166260 |
Uniprot | Q9Y6N1 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
COX11 | cuproptosis | 37979442 | Cu chaperones deliver Cu to COX, including COX11, COX17, COX19, COX23, SCO1(synthesis of cytochrome C oxidase 1), and SCO2. | Cu chaperones |
COX11 | cuproptosis | 38339398 | Cytochrome C Oxidase Copper Chaperone (COX11):Delivers copper to COX1 | copper ionophores |
COX11 | cuproptosis | 38006800 | Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C–C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. | cuproptosis-related genes |
COX11 | cuproptosis | 38006800 | COX11 is reported to the regulation of copper ions in diabetes-induced heart failure disease models. | regulator |
COX11 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
COX11 | cuproptosis | 38348451 | COX11 involved in copper delivery to cytochrome c oxidase and are crucial for mitochondrial function. | CRGs in the cuproptosis pathway |
COX11 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
COX11 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
COX11 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
COX11 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
Go Annotation:
GeneSymbol | Go id |
---|---|
COX11 | GO:0005507,GO:0005515,GO:0005739,GO:0005743,GO:0006754,GO:0009055,GO:0022900,GO:0030003,GO:0032991 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
COX11 | hsa:1353 | path:hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
COX11 | hsa:1353 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
COX11 | hsa:1353 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | COX11 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | COX11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | COX11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | COX11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ETS1 | COX11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | COX11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ERCC3 | COX11 | 25348397 | N/A | physical interaction | ComPPI |
PTPN1 | COX11 | 25348397 | N/A | physical interaction | ComPPI |
SQSTM1 | COX11 | 20562859 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
MTNR1A | COX11 | 24234451 25348397 26514267 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
KLK5 | COX11 | 25348397 | N/A | physical interaction | ComPPI |
MTNR1B | COX11 | 24234451 25348397 26514267 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
COX6B1 | COX11 | 24234451 25348397 27499296 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
RPL19 | COX11 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
NDUFA4 | COX11 | 25348397 | N/A | physical interaction | ComPPI |
COX11 | SCO1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |