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GENE：COX15

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX15
FullNmae cytochrome c oxidase assembly homolog COX15
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2263
EnsembleID ENSG00000014919
Uniprot Q7KZN9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX15 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
COX15 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COX15 GO:0004129,GO:0005515,GO:0005654,GO:0005739,GO:0005743,GO:0005743,GO:0005746,GO:0006123,GO:0006783,GO:0006784,GO:0006784,GO:0006784,GO:0007585,GO:0008535,GO:0016627,GO:0016653,GO:0020037,GO:0045333,GO:0060090,GO:0070069,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX15 hsa:1355 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX15 hsa:1355 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
COX15 hsa:1355 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX15 hsa:1355 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
COX15 hsa:1355 path:hsa04714 Thermogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 COX15 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 COX15 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001270D3 COX15 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004F507C COX15 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 COX15 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023F008 COX15 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA COX15 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000017EA6A COX15 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD COX15 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYNLL1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SAP18 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DDX21 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TFRC COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ERLIN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
LDHA COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EMD COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SET COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
H2BC4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC25A6 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NHP2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL10A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RHOA COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SCYL2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PFN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB7A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IRS4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SERPINH1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACTN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CANX COX15 24234451 25348397 29128334 29568061 association cross-linking study,pull down,physical interaction ComPPI,IntAct
EIF2AK2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SSBP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSP90B1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRDX4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
LAMTOR3 COX15 25348397 N/A physical interaction ComPPI
PABPC4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL28 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
XRCC6 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TXN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VDAC1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PABPC1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
BLM COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RBBP4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRAP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL12 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VDAC2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SRPK1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP1A1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
YWHAE COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
LMNB1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
BANF1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SUPT16H COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRIM28 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NOLC1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UQCRC2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRDX6 COX15 24234451 25348397 29128334 association,physical association anti bait coimmunoprecipitation,cross-linking study,physical interaction ComPPI,IntAct
SSR4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MYO6 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPUL1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPM1B COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPIA COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DYNC1H1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IMMT COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TRIM25 COX15 25348397 N/A physical interaction ComPPI
PTBP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ACIN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ELAVL1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NOP56 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ILF2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SAFB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GANAB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SMARCA5 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMA4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
OAT COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ALYREF COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RALY COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PNN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPAB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RBMXL2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
H2AC4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SAFB2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RNPS1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GNAI1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRDX3 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP2A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FLOT1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
THRAP3 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ERH COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CHMP4A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF4A3 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP2B COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SF3B6 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TMED10 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TIMM50 COX15 23260140 24234451 25348397 association blue native page ComPPI,IntAct
H2BC5 COX15 25348397 N/A physical interaction ComPPI
ARF1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EEF1E1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GNB1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MYO1C COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RRP12 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPH3 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
GSN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP5F1C COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPA1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RCN2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MYL1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC25A5 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FASN COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DKC1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NDUFA5 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL36 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FBL COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL30 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
AIFM1 COX15 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A3 COX15 23260140 24234451 25348397 29128334 association cross-linking study,physical interaction,blue native page ComPPI,IntAct
SLC25A4 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
STOML2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX4I1 COX15 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CYC1 COX15 25348397 N/A physical interaction ComPPI
SLC25A11 COX15 23260140 24234451 25348397 29128334 association cross-linking study,physical interaction,blue native page ComPPI,IntAct
DBN1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NDUFS6 COX15 25348397 N/A physical interaction ComPPI
H1-0 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL35A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPN2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL26 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
VDAC3 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP5PD COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FLOT2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DHX30 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
LMNB2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
H2BC11 COX15 25348397 N/A physical interaction ComPPI
NDUFS1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPM1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATAD3A COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DDOST COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL32 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SLC1A5 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DCD COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CAPZB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NDUFA9 COX15 25348397 N/A physical interaction ComPPI
HNRNPDL COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RPL35 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
QPCTL COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SFXN1 COX15 23260140 24234451 25348397 29128334 29568061 association cross-linking study,physical interaction,blue native page,proximity-dependent biotin identification ComPPI,IntAct
COX6B1 COX15 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CDK1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
H2BC1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
AIMP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ADAR COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
H1-10 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CLN3 COX15 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TMOD3 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MRPS21 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPUL2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NOP58 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RTCB COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 SURF1 25348397 N/A physical interaction ComPPI
COX15 NDUFS8 25348397 N/A physical interaction ComPPI
COX15 NDUFS4 25348397 N/A physical interaction ComPPI
COX15 NDUFA12 25348397 N/A physical interaction ComPPI
COX15 RPL27 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 CHTOP 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 MRPL49 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 NDUFA4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 H2AZ2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 NDUFS3 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 MACROH2A2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 TECR 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 ZC3HAV1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX15 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MRPL15 COX15 25348397 N/A physical interaction ComPPI

Visualization










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