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GENE：COX4I1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX4I1
FullNmae cytochrome c oxidase subunit 4I1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2265
EnsembleID ENSG00000131143
Uniprot P13073

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX4I1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
COX4I1 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COX4I1 GO:0004129,GO:0005515,GO:0005654,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005751,GO:0005751,GO:0005751,GO:0005829,GO:0006091,GO:0006123,GO:0006123,GO:0016020,GO:0031966,GO:0045333,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX4I1 hsa:1327 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa04714 Thermogenesis - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05010 Alzheimer disease - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05012 Parkinson disease - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05016 Huntington disease - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05020 Prion disease - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
COX4I1 hsa:1327 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COX4I1 COX5B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX5A COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX6C COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7B COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO1 COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO3 COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
LONP1 COX4I1 12198491 17418790 26192618 interaction type N/A ACSN
SURF1 COX4I1 10556303 11389896 15119951 19625251 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 COX4I1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A COX4I1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 COX4I1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000254A6 COX4I1 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge

Source Target Pmid Interactiontype Methods Database
COX4I1 COX5B 25361965 interaction type N/A PTMCode2
COX5B COX4I1 25361965 interaction type N/A PTMCode2
COX4I1 COX5A 25361965 interaction type N/A PTMCode2
COX5A COX4I1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CHCHD3 COX4I1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CORO1A COX4I1 25348397 N/A physical interaction ComPPI
ATP5PO COX4I1 25348397 N/A physical interaction ComPPI
COX4I1 MT-CO1 23260140 24234451 25348397 physical association physical interaction,blue native page,in vivo ComPPI,IntAct
COX4I1 NELFCD 25348397 N/A physical interaction ComPPI
COX4I1 TMBIM4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 APP 25348397 N/A physical interaction ComPPI
COX4I1 SDCBP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
COX4I1 FAF2 25348397 N/A physical interaction ComPPI
COX4I1 ECHS1 25348397 N/A physical interaction ComPPI
COX4I1 DBT 25348397 N/A physical interaction ComPPI
COX4I1 FMC1 25348397 N/A physical interaction ComPPI
COX4I1 GLDC 25348397 N/A physical interaction ComPPI
COX4I1 ALDOA 25348397 N/A physical interaction ComPPI
COX4I1 BCAP29 25348397 N/A physical interaction ComPPI
COX4I1 BCAP31 25348397 N/A physical interaction ComPPI
COX4I1 CISD2 25348397 N/A physical interaction ComPPI
COX4I1 ATP5F1D 25348397 N/A physical interaction ComPPI
COX4I1 ATP6V1A 25348397 N/A physical interaction ComPPI
COX4I1 ATP6V1E1 25348397 N/A physical interaction ComPPI
COX4I1 CISD1 25348397 N/A physical interaction ComPPI
COX4I1 GNB1 25348397 N/A physical interaction ComPPI
COX4I1 MAGT1 25348397 N/A physical interaction ComPPI
COX4I1 MT-CO2 19688755 24234451 25348397 29568061 association,physical association physical interaction,blue native page,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFA10 25348397 N/A physical interaction ComPPI
COX4I1 NDUFB7 25348397 N/A physical interaction ComPPI
COX4I1 PHB2 25348397 N/A physical interaction ComPPI
COX4I1 SDHB 25348397 N/A physical interaction ComPPI
COX4I1 UQCRC2 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 VAPA 25348397 N/A physical interaction ComPPI
COX4I1 VAPB 25348397 N/A physical interaction ComPPI
COX4I1 VDAC3 25348397 N/A physical interaction ComPPI
COX4I1 COX5A 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 DDOST 25348397 N/A physical interaction ComPPI
COX4I1 NDUFA2 25348397 N/A physical interaction ComPPI
COX4I1 NDUFS4 25348397 N/A physical interaction ComPPI
COX4I1 PHB 25348397 N/A physical interaction ComPPI
COX4I1 SSR3 25348397 N/A physical interaction ComPPI
COX4I1 SSR4 25348397 N/A physical interaction ComPPI
COX4I1 TPM1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TPM2 25348397 N/A physical interaction ComPPI
COX4I1 TPM3 25348397 N/A physical interaction ComPPI
COX4I1 TPM4 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 UQCRB 25348397 N/A physical interaction ComPPI
COX4I1 VDAC1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX4I1 VDAC2 25348397 N/A physical interaction ComPPI
COX4I1 JAK3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 TUBG1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 COA3 23260140 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 MTMR11 25348397 N/A physical interaction ComPPI
COX4I1 PPM1E 25348397 N/A physical interaction ComPPI
COX4I1 DUSP1 25348397 N/A physical interaction ComPPI
COX4I1 DUSP19 25348397 N/A physical interaction ComPPI
COX4I1 DUSP21 25348397 N/A physical interaction ComPPI
COX4I1 DUSP6 25348397 N/A physical interaction ComPPI
COX4I1 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
COX4I1 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
COX4I1 MCL1 25348397 N/A anti tag coimmunoprecipitation ComPPI
COX4I1 HSPD1 21274005 24234451 25348397 29568061 colocalization,association cosedimentation in solution,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TIMM21 23260140 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
COX4I1 COX6A2 23260140 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
COX4I1 SLC25A13 23260140 24234451 25348397 29568061 association blue native page,proximity-dependent biotin identification ComPPI,IntAct
COX4I1 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TIMM44 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MESD 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MTX2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TIMM13 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TIMM8B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 SAMM50 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 AFG3L2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 HYOU1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFA13 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TMOD3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 OCIAD1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 DNAJC11 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 IARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CLPB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CDCA3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 YME1L1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PTCD3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 SMIM12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 OMA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PYCR2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 FAM136A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COA7 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ACOT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX15 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TPGS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TTC19 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ATAD3B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COA6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MIX23 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ARID4B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 IMMT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFA9 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 HAGH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFA5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 KARS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ENDOG 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TP53BP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CKAP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 LACTB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 RBM11 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 HCCS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFA8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 LMAN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 UQCRFS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ETFB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 DLST 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CPOX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ATP5F1C 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MYH10 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 UQCRC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PDIA3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX6B1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX7A2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PRKCSH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 ETFA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 P4HA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PDIA4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX5B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX6C 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 GLS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MYO1D 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TOMM70 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CLPX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 SLC25A12 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFS3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFS6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 NDUFS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 OPA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TIMM8A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 CALU 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MYO1B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TRIAP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COPE 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 HAX1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 MGST3 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PLGRKT 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 TRMT61B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 COX4I1 24234451 29568061 association proximity-dependent biotin identification IntAct
COX4I1 UBE2O 24234451 30021884 physical association cross-linking study IntAct
COX4I1 TBCK 24234451 30021884 physical association cross-linking study IntAct
COX4I1 ATRX 24234451 30021884 physical association cross-linking study IntAct
COX4I1 PWWP2A 24234451 30021884 physical association cross-linking study IntAct
COX4I1 C1ORF52 24234451 30021884 physical association cross-linking study IntAct
COX4I1 ELP2 24234451 30021884 physical association cross-linking study IntAct
COX4I1 COX7B 24234451 30021884 physical association cross-linking study IntAct
COX4I1 TLCD4 24234451 30021884 physical association cross-linking study IntAct
POGZ COX4I1 24234451 30021884 physical association cross-linking study IntAct

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