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GENE：COX7A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX7A1
FullNmae cytochrome c oxidase subunit 7A1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2287
EnsembleID ENSG00000161281
Uniprot P24310

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX7A1 cuproptosis 38181713 The mitochondrial TCA cycle is a co-regulator of cystine-depleted ferroptosis and cuproptosis. COX7A1 and FAK accelerate the mitochondrial TCA cycle, increase production, and promote cystine-depleted ferroptosis and cuproptosis. driver

Go Annotation:

GeneSymbol Go id
COX7A1 GO:0002082,GO:0004129,GO:0005515,GO:0005739,GO:0005746,GO:0005751,GO:0006091,GO:0006123,GO:0097250,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX7A1 hsa:1346 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa04714 Thermogenesis - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05010 Alzheimer disease - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05012 Parkinson disease - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05016 Huntington disease - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05020 Prion disease - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
COX7A1 hsa:1346 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
YBX1 COX7A1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF COX7A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 COX7A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 COX7A1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
COX7A1 COX6C 25361965 interaction type N/A PTMCode2
COX6C COX7A1 25361965 interaction type N/A PTMCode2

Visualization










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