Gene Information gene info

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GENE：COX7B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX7B
FullNmae cytochrome c oxidase subunit 7B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2291
EnsembleID ENSG00000131174
Uniprot P24311

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX7B cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COX7B GO:0004129,GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0006123,GO:0007417,GO:0031966,GO:0045277,GO:0045333,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX7B hsa:1349 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX7B hsa:1349 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX7B hsa:1349 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
COX7B hsa:1349 path:hsa04714 Thermogenesis - Homo sapiens (human)
COX7B hsa:1349 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
COX7B hsa:1349 path:hsa05010 Alzheimer disease - Homo sapiens (human)
COX7B hsa:1349 path:hsa05012 Parkinson disease - Homo sapiens (human)
COX7B hsa:1349 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
COX7B hsa:1349 path:hsa05016 Huntington disease - Homo sapiens (human)
COX7B hsa:1349 path:hsa05020 Prion disease - Homo sapiens (human)
COX7B hsa:1349 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
COX7B hsa:1349 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
COX7B hsa:1349 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COX5A COX7B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX6C COX7B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7B COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7B COX5B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7B MT-CO1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7B MT-CO3 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX7B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX7B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7B COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
LONP1 COX7B 12198491 17418790 26192618 interaction type N/A ACSN
SURF1 COX7B 10556303 11389896 15119951 19625251 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 COX7B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 COX7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 COX7B 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000A057E COX7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 COX7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E COX7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA COX7B 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
COX6C COX7B 25361965 interaction type N/A PTMCode2
COX7B COX6C 25361965 interaction type N/A PTMCode2
COX5A COX7B 25361965 interaction type N/A PTMCode2
COX7B COX5A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNMT COX7B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MYB COX7B 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SLC25A13 COX7B 23260140 24234451 25348397 association blue native page ComPPI,IntAct
UNK COX7B 25348397 N/A physical interaction ComPPI
HSCB COX7B 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
COX4I1 COX7B 24234451 30021884 physical association cross-linking study IntAct

Source Target Pmid Interactiontype Methods Database
URS00009C3843 COX7B 27087310 direct interaction,inhibition N/A NPInter

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