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GENE：COX7C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol COX7C
FullNmae cytochrome c oxidase subunit 7C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2292
EnsembleID ENSG00000127184
Uniprot P15954

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
COX7C cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
COX7C GO:0005515,GO:0005739,GO:0005743,GO:0005751,GO:0005751,GO:0006091,GO:0006123,GO:0006123,GO:0031966,GO:0045333

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
COX7C hsa:1350 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
COX7C hsa:1350 path:hsa01100 Metabolic pathways - Homo sapiens (human)
COX7C hsa:1350 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
COX7C hsa:1350 path:hsa04714 Thermogenesis - Homo sapiens (human)
COX7C hsa:1350 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
COX7C hsa:1350 path:hsa05010 Alzheimer disease - Homo sapiens (human)
COX7C hsa:1350 path:hsa05012 Parkinson disease - Homo sapiens (human)
COX7C hsa:1350 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
COX7C hsa:1350 path:hsa05016 Huntington disease - Homo sapiens (human)
COX7C hsa:1350 path:hsa05020 Prion disease - Homo sapiens (human)
COX7C hsa:1350 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
COX7C hsa:1350 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
COX7C hsa:1350 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
COX5A COX7C 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX4I1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX5B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX6C 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX7B 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C MT-CO1 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C MT-CO3 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
MT-CO2 COX7C 11389896 15119951 16051147 17418790 19625251 26192618 8194600 interaction type N/A ACSN
COX7C COX4I2 17418790 26192618 8194600 interaction type N/A ACSN
LONP1 COX7C 12198491 17418790 26192618 interaction type N/A ACSN
SURF1 COX7C 10556303 11389896 15119951 19625251 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 COX7C 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 COX7C 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 COX7C 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 COX7C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA COX7C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF COX7C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 COX7C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS COX7C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
YY1 COX7C 9092564 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 COX7C N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC COX7C N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 COX7C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D COX7C 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC COX7C 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
COX7C COX5B 25361965 interaction type N/A PTMCode2
COX5B COX7C 25361965 interaction type N/A PTMCode2
COX7C COX6C 25361965 interaction type N/A PTMCode2
COX6C COX7C 25361965 interaction type N/A PTMCode2
COX7C COX5A 25361965 interaction type N/A PTMCode2
COX5A COX7C 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAGEA2 COX7C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NDUFAF4 COX7C 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPP COX7C 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
CIDEB COX7C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MT-CO2 COX7C 19688755 24234451 25348397 physical association blue native page ComPPI,IntAct
NDUFA4 COX7C 25348397 N/A physical interaction ComPPI
NMES1 COX7C 25348397 N/A physical interaction ComPPI
NDUFAF8 COX7C 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009BB656 COX7C 27087310 direct interaction,inhibition N/A NPInter

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