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GENE：CS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CS
FullNmae citrate synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2422
EnsembleID ENSG00000062485
Uniprot O75390

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CS ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CS ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CS cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CS GO:0003723,GO:0004108,GO:0004108,GO:0005634,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005759,GO:0005975,GO:0005975,GO:0006099,GO:0006099,GO:0006101,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CS hsa:1431 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
CS hsa:1431 path:hsa00630 Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
CS hsa:1431 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CS hsa:1431 path:hsa01200 Carbon metabolism - Homo sapiens (human)
CS hsa:1431 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
CS hsa:1431 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CS 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 CS 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CS 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 CS 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000AA464 CS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D CS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB CS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001799A3 CS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075BDA4 CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004D84DB CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000419B5A CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008DA94 CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000024CEE0 CS 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 CS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000031B6ED CS 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E2232 CS 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CS FXN 25361965 interaction type N/A PTMCode2
FXN CS 25361965 interaction type N/A PTMCode2
MDH2 CS 25361965 interaction type N/A PTMCode2
CS MDH2 25361965 interaction type N/A PTMCode2
USP11 CS 25361965 interaction type N/A PTMCode2
CS USP11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNRPB2 CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DYNLL1 CS 14525934 14760703 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CRYAA CS 11377425 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CRYAB CS 11377425 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBL4A CS 25348397 N/A physical interaction ComPPI
TRAF6 CS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MCM2 CS 25348397 N/A physical interaction ComPPI
SND1 CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF5B CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
UBE2N CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NTRK1 CS 25348397 N/A physical interaction ComPPI
PA2G4 CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF6 CS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDHX CS 25348397 N/A physical interaction ComPPI
CHM CS 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TRAP1 CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HUWE1 CS 25348397 N/A physical interaction ComPPI
ARF6 CS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HSPB1 CS 25348397 N/A physical interaction ComPPI
DLAT CS 25348397 N/A physical interaction ComPPI
USP11 CS 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB2 CS 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
IDH3A CS 25348397 N/A physical interaction ComPPI
CUL7 CS 25348397 N/A physical interaction ComPPI
HDAC5 CS 25348397 N/A physical interaction ComPPI
BCOR CS 25348397 N/A physical interaction ComPPI
SGK1 CS 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM25 CS 25348397 N/A physical interaction ComPPI
RAE1 CS 25348397 N/A physical interaction ComPPI
CLPP CS 24234451 25348397 26058080 association proximity-dependent biotin identification ComPPI,IntAct
ATF2 CS 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GPI CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SHMT2 CS 25348397 N/A physical interaction ComPPI
HSPD1 CS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ANXA5 CS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HSD17B10 CS 25348397 N/A physical interaction ComPPI
ACLY CS 25348397 N/A physical interaction ComPPI
CS ALDOA 25348397 N/A physical interaction ComPPI
CS CTPS1 25348397 N/A physical interaction ComPPI
CS MOV10 25348397 N/A physical interaction ComPPI
CS NXF1 25348397 N/A physical interaction ComPPI
CS SDHA 25348397 N/A physical interaction ComPPI
CS SDHB 25348397 N/A physical interaction ComPPI
CS ZNF207 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CS MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CS HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CS OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
CS PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
MDH2 CS 14525934 25348397 27898060 7285903 9792662 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
METTL14 CS 24234451 29507755 association anti tag coimmunoprecipitation IntAct
HSPE1 CS 24234451 30021884 physical association cross-linking study IntAct
CS ATXN7L1 24234451 30021884 physical association cross-linking study IntAct
PLEC CS 24234451 30021884 physical association cross-linking study IntAct

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