Gene Information gene info

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GENE：CYC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CYC1
FullNmae cytochrome c1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2579
EnsembleID ENSG00000179091
Uniprot P08574

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CYC1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CYC1 GO:0005515,GO:0005634,GO:0005739,GO:0005743,GO:0005743,GO:0005750,GO:0005750,GO:0006122,GO:0006122,GO:0008121,GO:0016020,GO:0020037,GO:0033762,GO:0045333,GO:0046872,GO:1902600

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CYC1 hsa:1537 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
CYC1 hsa:1537 path:hsa01100 Metabolic pathways - Homo sapiens (human)
CYC1 hsa:1537 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
CYC1 hsa:1537 path:hsa04714 Thermogenesis - Homo sapiens (human)
CYC1 hsa:1537 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05012 Parkinson disease - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05016 Huntington disease - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05020 Prion disease - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
CYC1 hsa:1537 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-CYB CYC1 15807660 26192618 interaction type N/A ACSN
UQCRB CYC1 15807660 26192618 interaction type N/A ACSN
UQCRC1 CYC1 15807660 26192618 interaction type N/A ACSN
UQCRC2 CYC1 15807660 26192618 interaction type N/A ACSN
UQCRFS1 CYC1 15807660 26192618 interaction type N/A ACSN
UQCRH CYC1 15807660 26192618 interaction type N/A ACSN
UQCRQ CYC1 15807660 26192618 interaction type N/A ACSN
GSK3B CYC1 12851486 23109003 inhibition N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 CYC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF CYC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CYC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CYC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CYC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F6 CYC1 10998368 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CYC1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 CYC1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CYC1 MDH2 25361965 interaction type N/A PTMCode2
MDH2 CYC1 25361965 interaction type N/A PTMCode2
CYC1 UQCR10 25361965 interaction type N/A PTMCode2
UQCR10 CYC1 25361965 interaction type N/A PTMCode2
CYC1 UQCRQ 25361965 interaction type N/A PTMCode2
UQCRQ CYC1 25361965 interaction type N/A PTMCode2
CYCS CYC1 25361965 interaction type N/A PTMCode2
CYC1 CYCS 25361965 interaction type N/A PTMCode2
UQCRC1 CYC1 25361965 interaction type N/A PTMCode2
CYC1 UQCRC1 25361965 interaction type N/A PTMCode2
UQCRH CYC1 25361965 interaction type N/A PTMCode2
CYC1 UQCRH 25361965 interaction type N/A PTMCode2
UQCRFS1 CYC1 25361965 interaction type N/A PTMCode2
CYC1 UQCRFS1 25361965 interaction type N/A PTMCode2
OXA1L CYC1 25361965 interaction type N/A PTMCode2
CYC1 OXA1L 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ATP5PO CYC1 25348397 N/A physical interaction ComPPI
RPN1 CYC1 25348397 N/A physical interaction ComPPI
NDUFAF3 CYC1 25348397 N/A physical interaction ComPPI
PPP2R1A CYC1 25348397 N/A physical interaction ComPPI
COX5A CYC1 25348397 N/A physical interaction ComPPI
CYCS CYC1 14525934 25348397 6262312 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UQCRH CYC1 25348397 N/A physical interaction ComPPI
NDUFAF4 CYC1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SAMM50 CYC1 25348397 N/A physical interaction ComPPI
JUN CYC1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
TAP1 CYC1 25348397 N/A physical interaction ComPPI
PEX19 CYC1 25348397 N/A physical interaction ComPPI
ACTN4 CYC1 25348397 N/A physical interaction ComPPI
ACTN1 CYC1 25348397 N/A physical interaction ComPPI
NTRK1 CYC1 25348397 N/A physical interaction ComPPI
NIT1 CYC1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CANX CYC1 25348397 N/A physical interaction ComPPI
SSBP1 CYC1 25348397 N/A physical interaction ComPPI
PHB CYC1 25348397 N/A physical interaction ComPPI
MYC CYC1 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
VDAC1 CYC1 25348397 N/A physical interaction ComPPI
TPM3 CYC1 25348397 N/A physical interaction ComPPI
RAB1A CYC1 25348397 N/A physical interaction ComPPI
ECT2 CYC1 25348397 N/A physical interaction ComPPI
CLTC CYC1 25348397 N/A physical interaction ComPPI
VDAC2 CYC1 25348397 N/A physical interaction ComPPI
ATP1A1 CYC1 25348397 N/A physical interaction ComPPI
ATP1B1 CYC1 25348397 N/A physical interaction ComPPI
HTT CYC1 17500595 24234451 25348397 association pull down ComPPI,IntAct
PHB2 CYC1 25348397 N/A physical interaction ComPPI
DLAT CYC1 25348397 N/A physical interaction ComPPI
RAB1B CYC1 25348397 N/A physical interaction ComPPI
LMAN1 CYC1 25348397 N/A physical interaction ComPPI
SSR1 CYC1 25348397 N/A physical interaction ComPPI
RCN1 CYC1 25348397 N/A physical interaction ComPPI
ATF2 CYC1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 CYC1 24234451 24983503 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
EYA2 CYC1 25348397 N/A physical interaction ComPPI
TOMM40 CYC1 25348397 N/A physical interaction ComPPI
OGDH CYC1 25348397 N/A physical interaction ComPPI
MTMR12 CYC1 25348397 N/A physical interaction ComPPI
ATP5F1A CYC1 25348397 N/A physical interaction ComPPI
MYL6 CYC1 25348397 N/A physical interaction ComPPI
UQCRB CYC1 25348397 N/A physical interaction ComPPI
MRPL4 CYC1 25348397 N/A physical interaction ComPPI
AIFM1 CYC1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SLC25A3 CYC1 25348397 N/A physical interaction ComPPI
CYC1 UQCRFS1 14525934 25348397 2999105 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CYC1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYC1 NDUFS4 25348397 N/A physical interaction ComPPI
CYC1 NDUFS8 25348397 N/A physical interaction ComPPI
CYC1 NDUFA12 25348397 N/A physical interaction ComPPI
CYC1 NDUFB10 25348397 N/A physical interaction ComPPI
CYC1 SURF1 25348397 N/A physical interaction ComPPI
CYC1 DHODH 25348397 N/A physical interaction ComPPI
CYC1 COX15 25348397 N/A physical interaction ComPPI
CYC1 RPUSD4 25348397 N/A physical interaction ComPPI
CYC1 MRPL58 25348397 N/A physical interaction ComPPI
CYC1 FBXO6 25348397 N/A physical interaction ComPPI
CYC1 ASB14 25348397 N/A physical interaction ComPPI
CYC1 MOV10 25348397 N/A physical interaction ComPPI
CYC1 HCCS 25348397 N/A physical interaction ComPPI
CYC1 UQCR10 25348397 N/A physical interaction ComPPI
CYC1 AFG3L2 25348397 N/A physical interaction ComPPI
CYC1 ATAD3A 25348397 N/A physical interaction ComPPI
CYC1 ATAD3B 25348397 N/A physical interaction ComPPI
CYC1 ATP5ME 25348397 N/A physical interaction ComPPI
CYC1 ATP1B3 25348397 N/A physical interaction ComPPI
CYC1 ATP5PD 25348397 N/A physical interaction ComPPI
CYC1 ATP5MG 25348397 N/A physical interaction ComPPI
CYC1 RAB1C 25348397 N/A physical interaction ComPPI
CYC1 SDHA 25348397 N/A physical interaction ComPPI
CYC1 TMCO1 25348397 N/A physical interaction ComPPI
CYC1 HSD17B12 25348397 N/A physical interaction ComPPI
CYC1 MRPL37 25348397 N/A physical interaction ComPPI
CYC1 MT-CYB 25348397 N/A physical interaction ComPPI
CYC1 MYH7B 25348397 N/A physical interaction ComPPI
CYC1 NDUFS3 25348397 N/A physical interaction ComPPI
CYC1 SGPL1 25348397 N/A physical interaction ComPPI
CYC1 VDAC3 25348397 N/A physical interaction ComPPI
CYC1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CYC1 NDUFA4 25348397 N/A physical interaction ComPPI
CYC1 ZNF746 25348397 N/A physical interaction ComPPI
CYC1 TPTE 25348397 N/A physical interaction ComPPI
CYC1 FLOT2 24234451 24983503 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
ILVBL CYC1 25348397 N/A physical interaction ComPPI
MRPL15 CYC1 25348397 N/A physical interaction ComPPI
HSCB CYC1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
CYC1 CYC1 14525934 15544925 N/A experimental interaction detection HPRD
CYC1 AGTPBP1 11900539 16893189 17128976 17972915 27898060 N/A N/A OmniPath

Visualization










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