Gene Information gene info

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GENE：DARS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DARS1
FullNmae aspartyl-tRNA synthetase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2678
EnsembleID ENSG00000115866
Uniprot P14868

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DARS1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
DARS1 GO:0003723,GO:0003723,GO:0004046,GO:0004815,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006412,GO:0006422,GO:0016020,GO:0017101,GO:0017101,GO:0045202,GO:0065003,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DARS1 hsa:1615 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR DARS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DARS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A DARS1 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
FOXP3 DARS1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DARS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000049FAE8 DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000036B845 DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D DARS1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 DARS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD DARS1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000F31F4 DARS1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000041FA2C DARS1 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 DARS1 25348397 N/A physical interaction ComPPI
AIMP2 DARS1 14525934 16189514 21900206 24234451 25348397 25416956 9878398 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
HSPA8 DARS1 24234451 25348397 29568061 association pull down ComPPI,IntAct
PTPN6 DARS1 25348397 N/A physical interaction ComPPI
KEAP1 DARS1 25348397 N/A physical interaction ComPPI
MCM2 DARS1 25348397 N/A physical interaction ComPPI
NF2 DARS1 25348397 N/A physical interaction ComPPI
TIAM1 DARS1 25348397 N/A physical interaction ComPPI
PIK3R1 DARS1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 DARS1 17474147 19380743 24234451 25348397 association,physical association peptide array,physical interaction,tandem affinity purification ComPPI,IntAct
JUN DARS1 24234451 25348397 25609649 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
USP7 DARS1 25348397 N/A physical interaction ComPPI
PKN2 DARS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
U2AF2 DARS1 25348397 N/A physical interaction ComPPI
CUL3 DARS1 25348397 N/A physical interaction ComPPI
PIK3R3 DARS1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBC DARS1 25348397 N/A physical interaction ComPPI
DLD DARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSP90AA1 DARS1 10913161 24234451 25348397 physical association two hybrid ComPPI,IntAct
NTRK1 DARS1 25348397 N/A physical interaction ComPPI
CANX DARS1 25348397 N/A physical interaction ComPPI
TLN1 DARS1 25348397 N/A physical interaction ComPPI
PSMA5 DARS1 25348397 N/A physical interaction ComPPI
PPP1CA DARS1 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
EEF1A1 DARS1 14525934 25348397 27898060 7806521 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CAD DARS1 25348397 N/A physical interaction ComPPI
CFTR DARS1 25348397 N/A physical interaction ComPPI
VDAC1 DARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF2S1 DARS1 25348397 N/A physical interaction ComPPI
NDRG1 DARS1 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SDCBP DARS1 25348397 N/A physical interaction ComPPI
EPRS1 DARS1 25348397 N/A physical interaction ComPPI
RPA2 DARS1 25348397 N/A physical interaction ComPPI
QARS1 DARS1 25348397 N/A physical interaction ComPPI
RPLP0 DARS1 25348397 N/A physical interaction ComPPI
CUL1 DARS1 25348397 N/A physical interaction ComPPI
RPL7A DARS1 25348397 N/A physical interaction ComPPI
EGFR DARS1 25348397 N/A physical interaction ComPPI
PFDN5 DARS1 25348397 N/A physical interaction ComPPI
MAP1LC3A DARS1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CSE1L DARS1 25348397 N/A physical interaction ComPPI
VCAM1 DARS1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 DARS1 25348397 N/A physical interaction ComPPI
DNM1L DARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MAP3K7 DARS1 25348397 N/A tandem affinity purification ComPPI
CUL7 DARS1 25348397 N/A physical interaction ComPPI
HDAC5 DARS1 25348397 N/A physical interaction ComPPI
CRY2 DARS1 25348397 N/A physical interaction ComPPI
KARS1 DARS1 25348397 N/A physical interaction ComPPI
ESR1 DARS1 24234451 25348397 25604459 association physical interaction,tandem affinity purification ComPPI,IntAct
BRCA1 DARS1 25348397 N/A physical interaction ComPPI
RPL23A DARS1 25348397 N/A physical interaction ComPPI
RPL13 DARS1 25348397 N/A physical interaction ComPPI
SOD1 DARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CRY1 DARS1 25348397 N/A physical interaction ComPPI
BET1 DARS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TNFRSF10D DARS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BAG2 DARS1 18457437 24234451 25348397 association tandem affinity purification ComPPI,IntAct
DLST DARS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DARS1 FBXO25 25348397 N/A physical interaction ComPPI
DARS1 AIMP1 25348397 N/A physical interaction ComPPI
DARS1 EEF1E1 25348397 N/A physical interaction ComPPI
DARS1 HMGCS1 25348397 N/A physical interaction ComPPI
DARS1 AARS1 25348397 N/A physical interaction ComPPI
DARS1 TRMT1 25348397 N/A physical interaction ComPPI
DARS1 FN1 25348397 N/A physical interaction ComPPI
DARS1 FBXO6 25348397 N/A physical interaction ComPPI
DARS1 RPL15 25348397 N/A physical interaction ComPPI
DARS1 RPL21 25348397 N/A physical interaction ComPPI
DARS1 RPL27A 25348397 N/A physical interaction ComPPI
DARS1 RPL3 25348397 N/A physical interaction ComPPI
DARS1 RPL26 25348397 N/A physical interaction ComPPI
DARS1 RPL36 25348397 N/A physical interaction ComPPI
DARS1 STAU1 25348397 N/A physical interaction ComPPI
DARS1 GFPT1 25348397 N/A physical interaction ComPPI
DARS1 FOXM1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
DARS1 CYLD 25348397 N/A physical interaction ComPPI
DARS1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATP6V1B2 DARS1 25348397 N/A physical interaction ComPPI

Visualization










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