GENE:DBH
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | DBH |
FullNmae | dopamine beta-hydroxylase |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:2689 |
EnsembleID | ENSG00000123454 |
Uniprot | P09172 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
DBH | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
DBH | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
DBH | cuproptosis | 38348451 | In cuproptosis, alterations in DBH activity could impact neurotransmitter synthesis and contribute to neuronal dysfunction. | CRGs in the cuproptosis pathway |
DBH | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
DBH | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
Go Annotation:
GeneSymbol | Go id |
---|---|
DBH | GO:0001974,GO:0001975,GO:0002443,GO:0003824,GO:0004500,GO:0004500,GO:0005507,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0005783,GO:0006589,GO:0007268,GO:0007613,GO:0007626,GO:0008542,GO:0016020,GO:0030658,GO:0030667,GO:0030667,GO:0031418,GO:0034451,GO:0034466,GO:0034774,GO:0034774,GO:0042309,GO:0042310,GO:0042420,GO:0042420,GO:0042421,GO:0042421,GO:0042421,GO:0042584,GO:0042593,GO:0042596,GO:0042711,GO:0043231,GO:0045202,GO:0045907,GO:0048149,GO:0048265,GO:0050900,GO:0120162,GO:1904705,GO:1905562,GO:2001236 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
DBH | hsa:1621 | path:hsa00350 | Tyrosine metabolism - Homo sapiens (human) |
DBH | hsa:1621 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ETS1 | DBH | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
MEF2A | DBH | 20009769 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
MYCN | DBH | 20009769 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
YBX1 | DBH | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
CREB1 | DBH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SP1 | DBH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TBP | DBH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SMARCA4 | DBH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | DBH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | DBH | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HAND2 | DBH | 14512028 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PHOX2A | DBH | 11034547 16280598 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PHOX2B | DBH | 11034547 15888479 16280598 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TFAP2A | DBH | 11146001 | trascriptional regulation,stimulation | inferred by curator | TFlink |
YY1 | DBH | 8753872 | trascriptional regulation,stimulation | inferred by curator | TFlink |
JUN | DBH | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |