Gene Information gene info

GENE:DBH

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DBH
FullNmae dopamine beta-hydroxylase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2689
EnsembleID ENSG00000123454
Uniprot P09172

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DBH apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DBH apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
DBH cuproptosis 38348451 In cuproptosis, alterations in DBH activity could impact neurotransmitter synthesis and contribute to neuronal dysfunction. CRGs in the cuproptosis pathway
DBH cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
DBH cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
DBH GO:0001974,GO:0001975,GO:0002443,GO:0003824,GO:0004500,GO:0004500,GO:0005507,GO:0005507,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0005783,GO:0006589,GO:0007268,GO:0007613,GO:0007626,GO:0008542,GO:0016020,GO:0030658,GO:0030667,GO:0030667,GO:0031418,GO:0034451,GO:0034466,GO:0034774,GO:0034774,GO:0042309,GO:0042310,GO:0042420,GO:0042420,GO:0042421,GO:0042421,GO:0042421,GO:0042584,GO:0042593,GO:0042596,GO:0042711,GO:0043231,GO:0045202,GO:0045907,GO:0048149,GO:0048265,GO:0050900,GO:0120162,GO:1904705,GO:1905562,GO:2001236

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DBH hsa:1621 path:hsa00350 Tyrosine metabolism - Homo sapiens (human)
DBH hsa:1621 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 DBH 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MEF2A DBH 20009769 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYCN DBH 20009769 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 DBH 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CREB1 DBH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 DBH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TBP DBH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 DBH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DBH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DBH 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HAND2 DBH 14512028 trascriptional regulation,stimulation inferred by curator TFlink
PHOX2A DBH 11034547 16280598 trascriptional regulation,stimulation inferred by curator TFlink
PHOX2B DBH 11034547 15888479 16280598 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A DBH 11146001 trascriptional regulation,stimulation inferred by curator TFlink
YY1 DBH 8753872 trascriptional regulation,stimulation inferred by curator TFlink
JUN DBH N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 DBH 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
NTRK1 DBH 25348397 N/A physical interaction ComPPI
ITSN1 DBH 16874303 24234451 25348397 colocalization imaging technique ComPPI,IntAct
DBH CLN3 25348397 N/A physical interaction ComPPI
DBH PPT1 25348397 N/A physical interaction ComPPI

Visualization