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GENE：DBT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DBT
FullNmae dihydrolipoamide branched chain transacylase E2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2698
EnsembleID ENSG00000137992
Uniprot P11182

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DBT pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DBT cuproptosis 38181713 The mitochondrial TCA cycle plays a crucial role in the occurrence of cuproptosis, where protein lipoylation is exclusive to four proteins (DBT, GCSH, DLST, and DLAT) involved in this cycle. driver
DBT cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
DBT cuproptosis 38348451 DBT is a component of the pyruvate dehydrogenase complex, a key player in energy metabolism. It contains lipoic acid, which forms a complex with copper. Changes in copper availability or metabolism may influence the function of DBT, affecting cellular energy balance. CRGs in the cuproptosis pathway
DBT cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
DBT cuproptosis 36341328 In addition, the knockout of nine genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, GCSH, and DBT) conferred resistance to cuproptosis driver
DBT cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
DBT cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
DBT GO:0005737,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005829,GO:0005947,GO:0009083,GO:0015630,GO:0016407,GO:0031405,GO:0031625,GO:0042645,GO:0043754

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DBT hsa:1629 path:hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human)
DBT hsa:1629 path:hsa00640 Propanoate metabolism - Homo sapiens (human)
DBT hsa:1629 path:hsa00785 Lipoic acid metabolism - Homo sapiens (human)
DBT hsa:1629 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DBT hsa:1629 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR DBT 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DBT 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DBT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DBT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DBT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DBT 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 DBT 19074876 25416803 27292025 mrna cleavage,inhibition array technology,clip TarBase
URS00000B59A2 DBT 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000005481D DBT 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000285DCB DBT 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 DBT 21572407 22927820 23313552 23446348 23706177 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004719AB DBT 21572407 23446348 23706177 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000B7E30 DBT 21572407 22927820 23313552 23446348 23706177 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000028DE3F DBT 21572407 23313552 23446348 23706177 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000085F64 DBT 21572407 22927820 23446348 23706177 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 DBT 21572407 22927820 23313552 23446348 23706177 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000486E0B DBT 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D DBT 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 DBT 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A DBT 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 DBT 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 DBT 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 DBT 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000086A4D DBT 23313552 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000048D44E DBT 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 DBT 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AAAFF DBT 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C DBT 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA DBT 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB DBT 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00007455B8 DBT 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 DBT 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 DBT 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000753AD DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043C1C3 DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000221168 DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000CC005 DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 DBT 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DLD DBT 25361965 interaction type N/A PTMCode2
DBT DLD 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KEAP1 DBT 25348397 N/A physical interaction ComPPI
NF2 DBT 25348397 N/A physical interaction ComPPI
JUN DBT 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
DLD DBT 25348397 N/A physical interaction ComPPI
YBX1 DBT 22118625 24234451 25348397 association tandem affinity purification ComPPI,IntAct
NPHP1 DBT 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RALB DBT 25348397 N/A physical interaction ComPPI
HUWE1 DBT 25348397 N/A physical interaction ComPPI
HDAC6 DBT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTEN DBT 25348397 N/A physical interaction ComPPI
TNFRSF1B DBT 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BCKDHB DBT 25348397 N/A physical interaction ComPPI
IDH3B DBT 25348397 N/A physical interaction ComPPI
PPP6C DBT 24234451 25348397 28330616 association pull down ComPPI,IntAct
PRKN DBT 25348397 N/A physical interaction ComPPI
NR3C1 DBT 25348397 N/A physical interaction ComPPI
NFKB1 DBT 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
NIN DBT 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SRRM2 DBT 25348397 N/A physical interaction ComPPI
CNTRL DBT 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CEP152 DBT 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
USP16 DBT 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GRPEL2 DBT 25348397 N/A physical interaction ComPPI
MED4 DBT 25348397 N/A physical interaction ComPPI
DLST DBT 25348397 N/A physical interaction ComPPI
ECHS1 DBT 25348397 N/A physical interaction ComPPI
IFIT2 DBT 21642987 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 DBT 25348397 N/A physical interaction ComPPI
ADI1 DBT 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LIPT1 DBT 25348397 N/A physical interaction ComPPI
MKS1 DBT 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DCAF11 DBT 25348397 N/A physical interaction ComPPI
THEM4 DBT 25348397 N/A physical interaction ComPPI
DBT AGO3 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DBT AGO4 19167051 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DBT ABCC1 25348397 N/A physical interaction ComPPI
DBT PPT1 25348397 N/A physical interaction ComPPI
DBT PPM1K 25348397 N/A physical interaction ComPPI
DBT MRRF 25348397 N/A physical interaction ComPPI
DBT FAHD2A 25348397 N/A physical interaction ComPPI
DBT MRM1 25348397 N/A physical interaction ComPPI
DBT CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DBT CEP164 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DBT RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DBT ACAD9 24234451 24344204 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DBT PPTC7 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DBT CDO1 25348397 N/A physical interaction ComPPI
DBT NOCT 25348397 N/A physical interaction ComPPI
DBT ZADH2 25348397 N/A physical interaction ComPPI
DBT MRPS11 25348397 N/A physical interaction ComPPI
DBT CA5B 25348397 N/A physical interaction ComPPI
DBT MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DBT SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
DBT NABP2 19683501 24234451 25348397 association pull down ComPPI,IntAct
DBT NABP1 19683501 24234451 25348397 association pull down ComPPI,IntAct
TRMT61B DBT 25348397 N/A physical interaction ComPPI
HNRNPU DBT 24234451 30021884 physical association cross-linking study IntAct
DDX1 DBT 24234451 30021884 physical association cross-linking study IntAct

Visualization










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