GENE：RPS6KA4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RPS6KA4 |
| FullNmae | ribosomal protein S6 kinase A4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10433 |
| EnsembleID | ENSG00000162302 |
| Uniprot | O75676 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RPS6KA4 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RPS6KA4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RPS6KA4 | GO:0000287,GO:0001818,GO:0004674,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006355,GO:0006355,GO:0006468,GO:0006954,GO:0018105,GO:0032793,GO:0035175,GO:0035556,GO:0043687,GO:0044022,GO:0045202,GO:0045944,GO:0051092,GO:0070498,GO:0106310 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RPS6KA4 | hsa:8986 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| RPS6KA4 | hsa:8986 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RPS6KA4 | MAPK14 | 11157753 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RNF2 | RPS6KA4 | 23180781 24457600 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK3 | RPS6KA4 | 23331499 9792677 | stimulation | N/A | SignaLink,SignaLink |
| RPS6KA4 | FOS | 23331499 9792677 | stimulation | N/A | SignaLink |
| MAPK14 | RPS6KA4 | 10806207 23331499 9792677 | stimulation | N/A | SignaLink |
| RPS6KA4 | CREB1 | 11175347 11909979 23331499 8688081 9687510 9792677 9829964 | stimulation | N/A | SignaLink |
| RPS6KA4 | ATF1 | 11909979 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | RPS6KA4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | RPS6KA4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | RPS6KA4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | RPS6KA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000BE495 | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BD6DC | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009EA8F | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004E02F2 | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000ECE9C | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004BACE | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000521626 | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000C73C | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BBF48 | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000002103A | RPS6KA4 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000027080C | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000E601 | RPS6KA4 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | RPS6KA4 | 25416803 27350436 | mrna cleavage,inhibition | nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000029D9F1 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000279B6F | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000081D1E | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000014F13C | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B12A4 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000148B91 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001310DE | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000005E58C | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E5ECC | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A6D0C | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F9738 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00005485E8 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411752 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E728C | RPS6KA4 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK2A1 | RPS6KA4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| RPS6KA4 | CREB1 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| RPS6KA4 | RELA | 22135298 | phosphorylation | N/A | PhosphoSite |
| RPS6KA4 | RPS6KA4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK14 | RPS6KA4 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| MAPK1 | RPS6KA4 | 25361965 | interaction type | N/A | PTMCode2 |
| RPS6KA4 | MAPK1 | 25361965 | interaction type | N/A | PTMCode2 |
| FOS | RPS6KA4 | 25361965 | interaction type | N/A | PTMCode2 |
| RPS6KA4 | FOS | 25361965 | interaction type | N/A | PTMCode2 |
| ATF1 | RPS6KA4 | 25361965 | interaction type | N/A | PTMCode2 |
| RPS6KA4 | ATF1 | 25361965 | interaction type | N/A | PTMCode2 |
| RPS6KA4 | MAPK14 | 25361965 | interaction type | N/A | PTMCode2 |
| RPS6KA4 | HMGN1 | 25361965 | interaction type | N/A | PTMCode2 |
| HMGN1 | RPS6KA4 | 25361965 | interaction type | N/A | PTMCode2 |
| CREB1 | RPS6KA4 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SNW1 | RPS6KA4 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CDC5L | RPS6KA4 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SH3KBP1 | RPS6KA4 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK1 | RPS6KA4 | 14525934 25348397 9687510 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MAPK3 | RPS6KA4 | 14525934 24234451 25348397 9792677 | physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| MAPK14 | RPS6KA4 | 10806207 14525934 23602568 24234451 25348397 25852190 9792677 | association,physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid | ComPPI,HPRD,IntAct |
| MAP2K1 | RPS6KA4 | 10806207 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RPS6KA4 | ATF1 | 11909979 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RPS6KA4 | CREB1 | 11175347 14525934 25348397 8688081 9687510 9792677 9829964 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| RPS6KA4 | HMGN1 | 11438671 12773393 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RPS6KA4 | FOS | 14525934 25348397 9792677 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| RPS6KA4 | NEDD4 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | DDX42 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | HECW2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | RNF2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | MYLK2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | DLG3 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | MESD | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | CDC37 | 24189400 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| RPS6KA4 | KLHDC3 | 25348397 | N/A | physical interaction | ComPPI |
| RPS6KA4 | RRP1B | 20926688 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| RPS6KA4 | RPS6KA4 | 14525934 17192257 9792677 | N/A | experimental interaction detection | HPRD |
| XRCC6 | RPS6KA4 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| RPS6KA4 | CREB1 | 11175347 11909979 17668895 18813292 27898060 8688081 9687510 9792677 9829964 | stimulant | N/A | OmniPath |
| RPS6KA4 | ATF1 | 11909979 18813292 20068231 20626350 27898060 8663317 | stimulant | N/A | OmniPath |
| MAP2K1 | RPS6KA4 | 10806207 16964243 18691976 19651622 20068231 27898060 | stimulant | N/A | OmniPath |
| RPS6KA4 | FOS | 22187936 27898060 8248197 9792677 | stimulant | N/A | OmniPath |
| MAPK3 | RPS6KA4 | 27898060 9792677 | stimulant | N/A | OmniPath |
| RPS6KA4 | H3C15 | 18813292 27898060 | N/A | N/A | OmniPath |
| MAPK14 | RPS6KA4 | 10806207 11035004 11157753 16964243 18691976 18813292 19651622 20068231 23602568 25852190 26186194 27898060 9792677 | stimulant | N/A | OmniPath |
| RPS6KA4 | RELA | 12628924 17183360 19933278 27898060 | stimulant | N/A | OmniPath |
| MAPK1 | RPS6KA4 | 11035004 18813292 27898060 9687510 | stimulant | N/A | OmniPath |
| RNF2 | RPS6KA4 | 24457600 27898060 | N/A | N/A | OmniPath |
| RPS6KA4 | HMGN1 | 11438671 12773393 17924679 20166139 27898060 | N/A | N/A | OmniPath |