GENE：DNA2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DNA2 |
| FullNmae | DNA replication helicase/nuclease 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2939 |
| EnsembleID | ENSG00000138346 |
| Uniprot | P51530 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DNA2 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DNA2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| DNA2 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| DNA2 | cuproptosis | 36685880 | A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. | cuproptosis-related genes |
| DNA2 | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DNA2 | GO:0000076,GO:0000723,GO:0000729,GO:0000781,GO:0003677,GO:0003678,GO:0003723,GO:0004386,GO:0004518,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005739,GO:0006260,GO:0006264,GO:0006284,GO:0016887,GO:0016890,GO:0017108,GO:0017108,GO:0017108,GO:0017116,GO:0032201,GO:0032508,GO:0033567,GO:0042645,GO:0043137,GO:0043139,GO:0043504,GO:0044806,GO:0045740,GO:0046872,GO:0051539,GO:0071932,GO:0090305,GO:0090656,GO:1902990 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DNA2 | hsa:1763 | path:hsa03030 | DNA replication - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | DNA2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | DNA2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000355E82 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | DNA2 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000365675 | DNA2 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FC26E | DNA2 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | DNA2 | 23313552 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C0099 | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D5FFC | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A057E | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000035CC3E | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | DNA2 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CIAO1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| CDR2 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKACB | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| LYN | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| EP300 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| PLAUR | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| BUB1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| RPA1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| FEN1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| AKAP11 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| RAD51 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| FANCD2 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| DNAJC7 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| RPA2 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| RPA3 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| RBBP8 | DNA2 | 25348397 25909997 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| MMS19 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| UPF1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| NRBP1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCSH | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| SHMT2 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| NOB1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| BORA | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| HMGCR | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| NXF1 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| MOV10 | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| WDHD1 | DNA2 | 22570476 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| WASHC2A | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| GCLM | DNA2 | 25348397 | N/A | physical interaction | ComPPI |
| PLEC | DNA2 | 24234451 30021884 | physical association | cross-linking study | IntAct |