Gene Information gene info

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GENE：DOT1L

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DOT1L
FullNmae DOT1 like histone lysine methyltransferase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24948
EnsembleID ENSG00000104885
Uniprot Q8TEK3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DOT1L cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
DOT1L GO:0000077,GO:0003676,GO:0003677,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006281,GO:0008284,GO:0010467,GO:0031151,GO:0031507,GO:0032200,GO:0032991,GO:0034729,GO:0042054,GO:0043231,GO:0045944,GO:0045944,GO:0046425,GO:0140938,GO:0140956,GO:2000677,GO:2000677

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DOT1L hsa:84444 path:hsa00310 Lysine degradation - Homo sapiens (human)
DOT1L hsa:84444 path:hsa01100 Metabolic pathways - Homo sapiens (human)
DOT1L hsa:84444 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR DOT1L 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DOT1L 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 DOT1L 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DOT1L 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000031E12 DOT1L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000321A1A DOT1L 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000076E54 DOT1L 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A DOT1L 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000060AABB DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000024A59E DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000076995 DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000272A3D DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004D84DB DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000101787 DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000913AC DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E6EFA DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004214BB DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDA4 DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000045147B DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C DOT1L 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SIRT1 DOT1L 25361965 interaction type N/A PTMCode2
DOT1L SIRT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ORC1 DOT1L 25348397 N/A physical interaction ComPPI
DDX21 DOT1L 25348397 N/A physical interaction ComPPI
NPM1 DOT1L 25348397 N/A physical interaction ComPPI
STAT1 DOT1L 22002246 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SKP1 DOT1L 20203130 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BAG6 DOT1L 22373577 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU DOT1L 25348397 N/A physical interaction ComPPI
AFF1 DOT1L 25348397 N/A physical interaction ComPPI
MAPK7 DOT1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYNCRIP DOT1L 25348397 N/A physical interaction ComPPI
H3-4 DOT1L 25348397 N/A physical interaction ComPPI
H3C15 DOT1L 20203130 24234451 25348397 methylation reaction physical interaction,methyltransferase assay,methyltransferase radiometric assay ComPPI,IntAct
YBX3 DOT1L 25348397 N/A physical interaction ComPPI
TRRAP DOT1L 20203130 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CTNNB1 DOT1L 20203130 21103407 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GNL3 DOT1L 25348397 N/A physical interaction ComPPI
SIRT1 DOT1L 19491102 20431927 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IBTK DOT1L 25348397 N/A physical interaction ComPPI
MLLT10 DOT1L 14525934 15851025 20203130 20431927 21103407 24234451 25348397 26496610 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
YEATS4 DOT1L 25348397 N/A physical interaction ComPPI
NIN DOT1L 25348397 N/A physical interaction ComPPI
CKAP5 DOT1L 25348397 N/A physical interaction ComPPI
MLLT6 DOT1L 19864429 20203130 24234451 25348397 26344197 26496610 27898060 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
ALYREF DOT1L 25348397 N/A physical interaction ComPPI
BRINP1 DOT1L 25348397 N/A physical interaction ComPPI
MLLT1 DOT1L 20153263 20203130 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H1-2 DOT1L 25348397 N/A physical interaction ComPPI
HNRNPM DOT1L 25348397 N/A physical interaction ComPPI
H2BC3 DOT1L 25348397 N/A physical interaction ComPPI
DOT1L MLLT3 16636056 17332896 20153263 20203130 20431927 20854876 21873227 21896721 23260655 24234451 25348397 26496610 27898060 association,physical association anti tag coimmunoprecipitation,nuclear magnetic resonance,pull down,physical interaction ComPPI,IntAct,OmniPath
DOT1L GRWD1 25348397 N/A physical interaction ComPPI
DOT1L H2AC1 25348397 N/A physical interaction ComPPI
DOT1L H1-10 25348397 N/A physical interaction ComPPI
DOT1L H1-1 25348397 N/A physical interaction ComPPI
DOT1L KMT2A 25348397 N/A physical interaction ComPPI
DOT1L PARP16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DOT1L INTS14 25348397 N/A physical interaction ComPPI
DOT1L RBM45 25348397 N/A physical interaction ComPPI
DOT1L KIF24 25348397 N/A physical interaction ComPPI
DOT1L TCF4 21103407 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EBNA1BP2 DOT1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMOX2 DOT1L 24234451 30021884 physical association cross-linking study IntAct
DOT1L MYC 26199140 27898060 stimulant N/A OmniPath
DOT1L H3C1 12123582 18022353 27898060 stimulant N/A OmniPath

Visualization










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