GENE：DPYD
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DPYD |
| FullNmae | dihydropyrimidine dehydrogenase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3012 |
| EnsembleID | ENSG00000188641 |
| Uniprot | Q12882 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DPYD | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Genes of iron-sulfur cluster related proteins |
| DPYD | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DPYD | GO:0002058,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006145,GO:0006208,GO:0006208,GO:0006210,GO:0006210,GO:0006212,GO:0006212,GO:0006214,GO:0006248,GO:0006249,GO:0017113,GO:0017113,GO:0017113,GO:0017113,GO:0019483,GO:0042803,GO:0042803,GO:0046050,GO:0046079,GO:0046872,GO:0050660,GO:0050661,GO:0050661,GO:0051539 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DPYD | hsa:1806 | path:hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| DPYD | hsa:1806 | path:hsa00410 | beta-Alanine metabolism - Homo sapiens (human) |
| DPYD | hsa:1806 | path:hsa00770 | Pantothenate and CoA biosynthesis - Homo sapiens (human) |
| DPYD | hsa:1806 | path:hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| DPYD | hsa:1806 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DPYD | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | DPYD | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | DPYD | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | DPYD | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DPYD | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | DPYD | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | DPYD | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000330617 | DPYD | 24401318 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001B341F | DPYD | 24401318 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000346991 | DPYD | 25416803 26457704 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000535FDD | DPYD | 25416803 25873402 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GAPDH | DPYD | 25348397 | N/A | physical interaction | ComPPI |
| CLK1 | DPYD | 25348397 | N/A | physical interaction | ComPPI |
| GOPC | DPYD | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| SP1 | DPYD | 16806531 27898060 | stimulant | N/A | OmniPath |