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GENE：EGLN1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EGLN1
FullNmae egl-9 family hypoxia inducible factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1232
EnsembleID ENSG00000135766
Uniprot Q9GZT9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EGLN1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
EGLN1 GO:0001666,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006879,GO:0008198,GO:0008198,GO:0014069,GO:0016706,GO:0018401,GO:0018401,GO:0019899,GO:0031418,GO:0031543,GO:0031545,GO:0031545,GO:0032364,GO:0043231,GO:0043433,GO:0045765,GO:0045944,GO:0051344,GO:0055008,GO:0060347,GO:0060412,GO:0060711,GO:0071456,GO:0071731,GO:0098978,GO:0099159,GO:0140252

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EGLN1 hsa:54583 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
EGLN1 hsa:54583 path:hsa05200 Pathways in cancer - Homo sapiens (human)
EGLN1 hsa:54583 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIF1A EGLN1 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17353276 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 23180781 24006507 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type,physical association pull down ACSN,InnateDB
FKBP8 EGLN1 17353276 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
EPAS1 EGLN1 17353276 23180781 physical association pull down InnateDB
HIF1AN EGLN1 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN3 EGLN1 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN1 FKBP8 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
ARNT EGLN1 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN1 HIF1A 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN1 EGLN2 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB
EGLN2 EGLN1 23180781 24145445 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR EGLN1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 EGLN1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EGLN1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 EGLN1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 EGLN1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A EGLN1 12839937 18971253 22075993 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 EGLN1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 EGLN1 22075993 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 EGLN1 22245592 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 EGLN1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C3AC1 EGLN1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000486E0B EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000002CF68 EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D EGLN1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D EGLN1 25416803 27030384 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
EPAS1 EGLN1 25361965 interaction type N/A PTMCode2
EGLN1 EPAS1 25361965 interaction type N/A PTMCode2
HIF1A EGLN1 25361965 interaction type N/A PTMCode2
EGLN1 HIF1A 25361965 interaction type N/A PTMCode2
VHL EGLN1 25361965 interaction type N/A PTMCode2
EGLN1 VHL 25361965 interaction type N/A PTMCode2
EGLN1 ING4 25361965 interaction type N/A PTMCode2
ING4 EGLN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RHOBTB3 EGLN1 25348397 N/A physical interaction ComPPI
SPRY2 EGLN1 25348397 N/A physical interaction ComPPI
KRAS EGLN1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
KEAP1 EGLN1 25348397 N/A physical interaction ComPPI
HSP90AB1 EGLN1 25348397 N/A physical interaction ComPPI
EGLN3 EGLN1 25348397 N/A physical interaction ComPPI
MAGEA9 EGLN1 25348397 N/A physical interaction ComPPI
SIAH2 EGLN1 25348397 N/A physical interaction ComPPI
SRC EGLN1 25348397 N/A physical interaction ComPPI
JUN EGLN1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HIF1A EGLN1 14525934 15474027 15721254 16511565 17353276 20840591 24234451 25348397 hydroxylation reaction,enzymatic reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,x-ray crystallography,physical interaction,enzymatic study,in vitro,in vivo ComPPI,HPRD,IntAct
PEX19 EGLN1 25348397 N/A physical interaction ComPPI
GPLD1 EGLN1 25348397 N/A physical interaction ComPPI
HSP90AA1 EGLN1 25348397 N/A physical interaction ComPPI
PLD2 EGLN1 25348397 N/A physical interaction ComPPI
CANX EGLN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PTGES3 EGLN1 25348397 N/A physical interaction ComPPI
CBFA2T3 EGLN1 25348397 N/A physical interaction ComPPI
PKM EGLN1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
SDCBP EGLN1 24234451 25348397 26787460 N/A phage display ComPPI,IntAct
VHL EGLN1 25348397 N/A two hybrid,physical interaction ComPPI
FKBP4 EGLN1 25348397 N/A physical interaction ComPPI
POLR2A EGLN1 25348397 N/A physical interaction ComPPI
ING4 EGLN1 25348397 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI
HIF3A EGLN1 14525934 15474027 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
H3C1 EGLN1 19624289 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FKBP8 EGLN1 17353276 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy,gal4 vp16 complementation ComPPI,IntAct
OS9 EGLN1 14525934 15721254 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
AKT1 EGLN1 25348397 N/A physical interaction ComPPI
EPAS1 EGLN1 14525934 15474027 17353276 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,gal4 vp16 complementation ComPPI,HPRD,IntAct
SNUPN EGLN1 25348397 N/A physical interaction ComPPI
EZR EGLN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LIMD1 EGLN1 25348397 N/A physical interaction ComPPI
MAGEA11 EGLN1 25348397 N/A physical interaction ComPPI
EGLN1 ZNF281 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EGLN1 FKBP5 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGLN1 PLD1 25348397 N/A physical interaction ComPPI
EGLN1 RFPL4B 25348397 N/A physical interaction ComPPI
EGLN1 CBWD1 25348397 N/A physical interaction ComPPI
EGLN1 CBWD2 25348397 N/A physical interaction ComPPI
EGLN1 MKS1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EGLN1 HSP90AA2P 25348397 N/A physical interaction ComPPI
EGLN1 EEF1AKMT1 25348397 N/A physical interaction ComPPI
AKT2 EGLN1 25348397 N/A physical interaction ComPPI
EGLN1 ERP29 24234451 30021884 physical association cross-linking study IntAct
OS9 EGLN1 15721254 16391536 21559462 27898060 stimulant N/A OmniPath
HIF1A EGLN1 15474027 15721254 16407130 16511565 17353276 18264140 19604478 20724477 20840591 24145445 25361009 26611735 27898060 stimulant N/A OmniPath
EGLN1 HIF1A 15474027 15721254 16391536 16407130 16511565 17353276 18264140 19604478 20724477 20840591 24145445 25361009 26611735 27898060 inhibition,stimulant N/A OmniPath

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