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GENE：EIF3I

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF3I
FullNmae eukaryotic translation initiation factor 3 subunit I
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3272
EnsembleID ENSG00000084623
Uniprot Q13347

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF3I cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
EIF3I GO:0001732,GO:0002183,GO:0003723,GO:0003743,GO:0003743,GO:0003743,GO:0005515,GO:0005829,GO:0005852,GO:0005852,GO:0006413,GO:0006413,GO:0016282,GO:0033290,GO:0045202,GO:0070062,GO:0071541

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EIF3D EIF3I 18628297 23180781 physical association anti tag coimmunoprecipitation InnateDB
RNF2 EIF3I 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
TGFBR1 EIF3I 23331499 9813058 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 EIF3I 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 EIF3I 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC EIF3I N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 EIF3I 21512034 23622248 25416803 mrna cleavage,inhibition experimental interaction detection,clash TarBase
URS000032FC1A EIF3I 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004B4B85 EIF3I 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E EIF3I 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002B2B5C EIF3I 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 EIF3I 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
EIF3F EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3F 25361965 interaction type N/A PTMCode2
RPS16 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I RPS16 25361965 interaction type N/A PTMCode2
ABCE1 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I ABCE1 25361965 interaction type N/A PTMCode2
RPS5 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I RPS5 25361965 interaction type N/A PTMCode2
EIF3J EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3J 25361965 interaction type N/A PTMCode2
EIF3A EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3A 25361965 interaction type N/A PTMCode2
EIF3D EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3D 25361965 interaction type N/A PTMCode2
EIF3B EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3B 25361965 interaction type N/A PTMCode2
EIF2S1 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF2S1 25361965 interaction type N/A PTMCode2
EIF3G EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3G 25361965 interaction type N/A PTMCode2
RPS14 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I RPS14 25361965 interaction type N/A PTMCode2
EIF3C EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3C 25361965 interaction type N/A PTMCode2
EIF3E EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF3E 25361965 interaction type N/A PTMCode2
RPS9 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I RPS9 25361965 interaction type N/A PTMCode2
EIF4G1 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF4G1 25361965 interaction type N/A PTMCode2
EIF3I USP3 25361965 interaction type N/A PTMCode2
USP3 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I RPS6 25361965 interaction type N/A PTMCode2
RPS6 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I RPS8 25361965 interaction type N/A PTMCode2
RPS8 EIF3I 25361965 interaction type N/A PTMCode2
TGFBR2 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I TGFBR2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EIF3G EIF3I 17094969 18599441 24234451 25348397 physical association two hybrid,mass spectrometry studies of complexes,physical interaction,two hybrid array ComPPI,IntAct
SNW1 EIF3I 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC5L EIF3I 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF1B EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3H EIF3I 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK2 EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NPM1 EIF3I 25348397 N/A physical interaction ComPPI
RPL37A EIF3I 25348397 N/A physical interaction ComPPI
TGFB1 EIF3I 14525934 25348397 9813058 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TRAF6 EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ACTB EIF3I 15047060 24234451 25348397 physical association molecular sieving ComPPI,IntAct
RAN EIF3I 25348397 N/A physical interaction ComPPI
RAD21 EIF3I 25348397 N/A physical interaction ComPPI
EIF3E EIF3I 25348397 N/A physical interaction ComPPI
EIF5 EIF3I 25348397 N/A physical interaction ComPPI
CD4 EIF3I 25348397 N/A physical interaction ComPPI
TGFBR2 EIF3I 11781097 14525934 25348397 7566156 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RPL10 EIF3I 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD81 EIF3I 25348397 N/A physical interaction ComPPI
EIF4G1 EIF3I 25348397 N/A physical interaction,in vivo ComPPI
GLI1 EIF3I 25348397 N/A physical interaction ComPPI
LIG4 EIF3I 25348397 N/A physical interaction ComPPI
PAXIP1 EIF3I 25348397 N/A physical interaction ComPPI
CUL3 EIF3I 25348397 N/A physical interaction ComPPI
DLD EIF3I 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NTRK1 EIF3I 25348397 N/A physical interaction ComPPI
YBX1 EIF3I 25348397 N/A physical interaction ComPPI
SUB1 EIF3I 25348397 N/A physical interaction ComPPI
MYC EIF3I 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
UBR5 EIF3I 25348397 N/A physical interaction ComPPI
CFTR EIF3I 25348397 N/A physical interaction ComPPI
EIF6 EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3C EIF3I 18599441 24234451 25348397 physical association mass spectrometry studies of complexes,physical interaction ComPPI,IntAct
EIF3F EIF3I 25348397 N/A physical interaction ComPPI
CCNA1 EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ARRB1 EIF3I 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HUWE1 EIF3I 25348397 N/A physical interaction ComPPI
PDCD4 EIF3I 25348397 N/A physical interaction ComPPI
RPS13 EIF3I 25348397 N/A physical interaction ComPPI
ARF6 EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EPB41L1 EIF3I 25348397 N/A physical interaction ComPPI
CDK2 EIF3I 25348397 N/A physical interaction ComPPI
SFN EIF3I 25348397 N/A physical interaction ComPPI
RNF2 EIF3I 25348397 N/A physical interaction ComPPI
BRD1 EIF3I 25348397 N/A physical interaction ComPPI
EIF3I EIF3A 14525934 17353931 18599441 24234451 25348397 8995409 physical association anti bait coimmunoprecipitation,experimental interaction detection,mass spectrometry studies of complexes,physical interaction,in vivo ComPPI,HPRD,IntAct
EIF3I EIF3B 14525934 14688252 18599441 18628297 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,mass spectrometry studies of complexes,physical interaction,in vivo ComPPI,HPRD,IntAct
EIF3I EXOSC6 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
EIF3I ESR1 10706629 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
EIF3I SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EIF3I USP3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I SRRM2 25348397 N/A physical interaction ComPPI
EIF3I TADA2A 25348397 N/A physical interaction ComPPI
EIF3I CLEC4G 18624398 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
EIF3I SIRT7 25348397 N/A physical interaction ComPPI
EIF3I EIF3D 25348397 N/A physical interaction ComPPI
EIF3I EIF3K 25348397 N/A physical interaction ComPPI
EIF3I EIF3M 25348397 N/A physical interaction ComPPI
EIF3I EIF3L 25348397 N/A physical interaction ComPPI
EIF3I DDX3X 18628297 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
EIF3I METTL18 25348397 N/A physical interaction ComPPI
EIF3I ITGA4 25348397 N/A physical interaction ComPPI
EIF3I PAN2 25348397 N/A physical interaction ComPPI
EIF3I IGSF8 25348397 N/A physical interaction ComPPI
EIF3I ICAM1 25348397 N/A physical interaction ComPPI
EIF3I CDK18 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF3I TARDBP 25348397 N/A physical interaction ComPPI
EIF3I HECW2 25348397 N/A physical interaction ComPPI
EIF3I HERC2 24234451 25348397 29426014 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I HERC2P3 25348397 N/A physical interaction ComPPI
EIF3I PRRC2B 25348397 N/A physical interaction ComPPI
EIF3I EIF3CL 25348397 N/A physical interaction ComPPI
EIF3I EIF3J 14688252 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I TRIP12 25348397 N/A physical interaction ComPPI
EIF3I DNAJA4 25348397 N/A physical interaction ComPPI
EIF3I DCAF10 25348397 N/A physical interaction ComPPI
EIF3I EIF2B5 25348397 N/A physical interaction ComPPI
EIF3I CPNE8 25348397 N/A physical interaction ComPPI
EIF3I LMAN1 25348397 N/A physical interaction ComPPI
EIF3I MYL9 25348397 N/A physical interaction ComPPI
EIF3I NDUFB5 25348397 N/A physical interaction ComPPI
EIF3I SETD2 25348397 N/A physical interaction ComPPI
EIF3I TRA2B 25348397 N/A physical interaction ComPPI
EIF3I NUMA1 25348397 N/A physical interaction ComPPI
EIF3I POLR1C 25348397 N/A physical interaction ComPPI
EIF3I SLC3A2 25348397 N/A physical interaction ComPPI
EIF3I SRSF6 25348397 N/A physical interaction ComPPI
EIF3I SRSF7 25348397 N/A physical interaction ComPPI
EIF3I TMED2 25348397 N/A physical interaction ComPPI
EIF3I KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I MYO1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I NES 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I L1TD1 24234451 25348397 25702638 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3I GAN 25348397 N/A physical interaction ComPPI
EIF3I RC3H1 25348397 N/A physical interaction ComPPI
EIF3I ZNF746 25348397 N/A physical interaction ComPPI
EIF3I CERKL 25348397 N/A physical interaction ComPPI
EIF3I EIF4A1 25348397 N/A physical interaction ComPPI
EIF3I CYLD 25348397 N/A physical interaction ComPPI
EIF3I HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF3I SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF3I G3BP1 25348397 N/A physical interaction ComPPI
EIF3I CCND2 25348397 N/A physical interaction ComPPI
EIF3I BRCA1 25348397 N/A physical interaction ComPPI
EIF3I TES 25348397 N/A physical interaction ComPPI
EIF3I SGK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3I TFE3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3I MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3I HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3I GH1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3I TNFRSF14 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3I WIPI2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF3I PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
SRRM1 EIF3I 25348397 N/A physical interaction ComPPI
LYAR EIF3I 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MTS EIF3I 14605208 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FOXO EIF3I 25348397 N/A physical interaction ComPPI
RAS85D EIF3I 25348397 N/A physical interaction ComPPI
PDK1 EIF3I 25348397 N/A physical interaction ComPPI
LET-756 EIF3I 16672054 24234451 physical association two hybrid IntAct
DHX15 EIF3I 24234451 29021621 association anti tag coimmunoprecipitation IntAct
EIF3I C5ORF58 24234451 30021884 physical association cross-linking study IntAct
EIF3I IFT172 24234451 30021884 physical association cross-linking study IntAct
TPT1 EIF3I 24234451 27607350 association anti bait coimmunoprecipitation IntAct
TGFBR2 EIF3I 11781097 27898060 7566156 stimulant N/A OmniPath
EIF3I TGFBR2 11781097 27898060 7566156 9774674 stimulant N/A OmniPath
TGFBR1 EIF3I 27898060 9813058 stimulant N/A OmniPath

Visualization










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