Gene Information gene info

  1. Home

GENE：EIF4G1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF4G1
FullNmae eukaryotic translation initiation factor 4 gamma 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3296
EnsembleID ENSG00000114867
Uniprot Q04637

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF4G1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EIF4G1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
EIF4G1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
EIF4G1 GO:0001662,GO:0002191,GO:0003723,GO:0003723,GO:0003729,GO:0003729,GO:0003743,GO:0003743,GO:0003743,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005844,GO:0006412,GO:0006412,GO:0006413,GO:0006413,GO:0006413,GO:0006446,GO:0006446,GO:0008135,GO:0008190,GO:0008190,GO:0009059,GO:0010494,GO:0010507,GO:0010801,GO:0016020,GO:0016281,GO:0016281,GO:0016281,GO:0030182,GO:0030307,GO:0030324,GO:0031369,GO:0031669,GO:0033138,GO:0035278,GO:0035278,GO:0036493,GO:0042802,GO:0045471,GO:0045666,GO:0051247,GO:0060090,GO:0080135,GO:0097009,GO:0098794,GO:1900087,GO:1904377,GO:1905537,GO:1905606,GO:1905612,GO:1905696

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EIF4G1 hsa:1981 path:hsa05416 Viral myocarditis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EIF4G1 TRAF2 15743837 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
EIF4E EIF4G1 15153109 16467844 16648488 17689282 23180781 8521827 physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down InnateDB
EIF4G1 MKNK1 23180781 9878069 physical association anti tag coimmunoprecipitation InnateDB
ISG15 EIF4G1 16009940 23180781 physical association unspecified method InnateDB
EIF4G1 UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR EIF4G1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EIF4G1 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EIF4G1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EIF4G1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EIF4G1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EIF4G1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EIF4G1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF4G1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EIF4G1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 EIF4G1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000016FF9C EIF4G1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EC1BE EIF4G1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AD002 EIF4G1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 EIF4G1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD EIF4G1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 EIF4G1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000022AAA EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001B12A4 EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000020579D EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000331800 EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 EIF4G1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 EIF4G1 22135298 phosphorylation N/A PhosphoSite
CDK2 EIF4G1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 EIF4G1 22135298 phosphorylation N/A PhosphoSite
PRKCA EIF4G1 22135298 phosphorylation N/A PhosphoSite
PAK2 EIF4G1 22135298 phosphorylation N/A PhosphoSite
EIF3F EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 EIF3F 25361965 interaction type N/A PTMCode2
HSPB1 EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 HSPB1 25361965 interaction type N/A PTMCode2
EIF3J EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 EIF3J 25361965 interaction type N/A PTMCode2
PABPC1 EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 PABPC1 25361965 interaction type N/A PTMCode2
EIF4A1 EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 EIF4A1 25361965 interaction type N/A PTMCode2
EIF4G1 EIF3B 25361965 interaction type N/A PTMCode2
EIF3B EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 EIF3A 25361965 interaction type N/A PTMCode2
EIF3A EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 MKNK1 25361965 interaction type N/A PTMCode2
MKNK1 EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 EIF3I 25361965 interaction type N/A PTMCode2
EIF3I EIF4G1 25361965 interaction type N/A PTMCode2
EIF4G1 USP3 25361965 interaction type N/A PTMCode2
USP3 EIF4G1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SF3A3 EIF4G1 25348397 N/A physical interaction ComPPI
HNRNPK EIF4G1 23974796 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
AIMP2 EIF4G1 25348397 N/A physical interaction ComPPI
FTL EIF4G1 25348397 N/A physical interaction ComPPI
FXR2 EIF4G1 23974796 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3H EIF4G1 25348397 N/A physical interaction ComPPI
PAK2 EIF4G1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,in vivo ComPPI,IntAct
ZFYVE9 EIF4G1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SGTB EIF4G1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ISG15 EIF4G1 25348397 N/A physical interaction ComPPI
PSMC3 EIF4G1 25348397 N/A physical interaction ComPPI
MAGEA6 EIF4G1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 EIF4G1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 EIF4G1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXB1 EIF4G1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RAD21 EIF4G1 25348397 N/A physical interaction ComPPI
KEAP1 EIF4G1 25348397 N/A physical interaction ComPPI
MCM2 EIF4G1 25348397 N/A physical interaction ComPPI
EIF5 EIF4G1 25348397 N/A in vitro,in vivo ComPPI
SF3A2 EIF4G1 25348397 N/A physical interaction ComPPI
JUN EIF4G1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 NCBP1 11340157 15361857 24234451 25049393 25348397 27898060 association coimmunoprecipitation,far western blotting,physical interaction,in vivo ComPPI,IntAct,OmniPath
EIF4G1 EIF4A2 11408474 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction,in vitro ComPPI,IntAct
EIF4G1 EIF4A1 11408474 16932749 17353931 18606994 19203580 23023399 23478064 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,dynamic light scattering,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,IntAct
EIF4G1 PABPC1 12086624 16772376 19716330 24234451 25348397 9857202 physical association coimmunoprecipitation,isothermal titration calorimetry,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,IntAct
EIF4G1 HSPB1 10859165 24234451 25348397 27898060 N/A filter binding,in vitro ComPPI,IntAct,OmniPath
EIF4G1 UPF2 15361857 24234451 25348397 association coimmunoprecipitation,in vivo ComPPI,IntAct
EIF4G1 PDCD4 12054647 24234451 25348397 physical association pull down,physical interaction,in vitro ComPPI,IntAct
EIF4G1 NCBP2 15361857 24234451 25348397 association far western blotting,in vivo ComPPI,IntAct
EIF4G1 ANXA5 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EIF4G1 EIF3A 25348397 N/A physical interaction,in vivo ComPPI
EIF4G1 EIF3B 23023399 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
EIF4G1 EIF3I 25348397 N/A physical interaction,in vivo ComPPI
EIF4G1 EIF4E 15153109 15361857 18955708 20212144 21191102 23665581 24234451 25348397 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
EIF4G1 NELFCD 25348397 N/A physical interaction ComPPI
EIF4G1 MKNK2 25348397 N/A physical interaction ComPPI
EIF4G1 MKNK1 24234451 25348397 9878069 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 HNRNPD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
EIF4G1 USP10 25348397 N/A physical interaction ComPPI
EIF4G1 EIF3F 25348397 N/A physical interaction ComPPI
EIF4G1 USP3 25348397 N/A physical interaction ComPPI
EIF4G1 G3BP1 18005740 23209657 24234451 25348397 colocalization fluorescence technology,physical interaction,confocal microscopy ComPPI,IntAct
EIF4G1 UBE3A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF4G1 CENPU 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF4G1 SIRT7 25348397 N/A physical interaction ComPPI
EIF4G1 CUL3 25348397 N/A physical interaction ComPPI
EIF4G1 TRAF2 25348397 N/A physical interaction ComPPI
EIF4G1 EIF4G2 25348397 N/A physical interaction ComPPI
EIF4G1 EIF4B 25348397 N/A physical interaction ComPPI
EIF4G1 EIF4G3 25348397 N/A physical interaction ComPPI
EIF4G1 RAB31 25348397 N/A physical interaction ComPPI
EIF4G1 ESR1 21182205 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
EIF4G1 FN1 25348397 N/A physical interaction ComPPI
EIF4G1 VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
EIF4G1 HTRA2 25348397 N/A physical interaction ComPPI
EIF4G1 ITGA4 25348397 N/A physical interaction ComPPI
EIF4G1 BRCA1 25348397 N/A physical interaction ComPPI
EIF4G1 GK 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF4G1 TARDBP 25348397 N/A physical interaction ComPPI
EIF4G1 AIMP1 25348397 N/A physical interaction ComPPI
EIF4G1 EEF1E1 25348397 N/A physical interaction ComPPI
EIF4G1 PSMB8 25348397 N/A physical interaction ComPPI
EIF4G1 PTBP1 25348397 N/A physical interaction ComPPI
EIF4G1 QARS1 25348397 N/A physical interaction ComPPI
EIF4G1 LGR4 25348397 N/A physical interaction ComPPI
EIF4G1 POLDIP3 25348397 N/A physical interaction ComPPI
EIF4G1 CUL7 25348397 N/A physical interaction ComPPI
EIF4G1 CCDC8 25348397 N/A physical interaction ComPPI
EIF4G1 MAMDC2 25348397 N/A physical interaction ComPPI
EIF4G1 UNK 25348397 N/A physical interaction ComPPI
EIF4G1 DCTN4 25348397 N/A physical interaction ComPPI
EIF4G1 PUM3 25348397 N/A physical interaction ComPPI
EIF4G1 NAT10 25348397 N/A physical interaction ComPPI
EIF4G1 PUS7 25348397 N/A physical interaction ComPPI
EIF4G1 SF3A1 25348397 N/A physical interaction ComPPI
EIF4G1 MTREX 25348397 N/A physical interaction ComPPI
EIF4G1 FBL 25348397 N/A physical interaction ComPPI
EIF4G1 NUP50 25348397 N/A physical interaction ComPPI
EIF4G1 PABPC4 25348397 N/A physical interaction ComPPI
EIF4G1 POLE 25348397 N/A physical interaction ComPPI
EIF4G1 SF3B3 23974796 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 TNKS1BP1 25348397 N/A physical interaction ComPPI
EIF4G1 NTRK1 25348397 N/A physical interaction ComPPI
EIF4G1 HERC2 25348397 N/A physical interaction ComPPI
EIF4G1 HERC2P3 25348397 N/A physical interaction ComPPI
EIF4G1 SRPK2 25348397 N/A physical interaction ComPPI
EIF4G1 CLCN2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 HSPA5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 TOR1AIP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 ACTR5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 CNTROB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EIF4G1 RC3H1 25348397 N/A physical interaction ComPPI
EIF4G1 SLBP 25348397 N/A physical interaction ComPPI
EIF4G1 CDH1 25348397 N/A physical interaction ComPPI
EIF4G1 GCHFR 25348397 N/A physical interaction ComPPI
EIF4G1 NFATC2IP 25348397 N/A physical interaction ComPPI
EIF4G1 EMILIN1 25348397 N/A physical interaction ComPPI
EIF4G1 CYLD 25348397 N/A physical interaction ComPPI
EIF4G1 DLD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF4G1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF4G1 PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
EIF4G1 TRIM25 25348397 N/A physical interaction ComPPI
EIF4G1 RBM4 25348397 N/A anti tag coimmunoprecipitation,pull down,physical interaction ComPPI
EIF4G1 UPF3B 15361857 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
EIF4G1 EIF3J 16932749 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
EIF4G1 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 ARF6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 YWHAZ 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
EIF4G1 INTS6 17469741 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 ZC3H7B 15047801 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,three hybrid ComPPI,IntAct,OmniPath
EIF4G1 DDX3X 22872150 24234451 25348397 colocalization,association anti tag coimmunoprecipitation,pull down,fluorescence microscopy ComPPI,IntAct
EIF4G1 TNRC6C 19716330 24234451 25348397 association pull down ComPPI,IntAct
EIF4G1 CHAF1B 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
EIF4G1 PUF60 23974796 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 FXR1 23974796 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF4G1 NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
IQGAP1 EIF4G1 25348397 N/A physical interaction ComPPI
EIF4A3 EIF4G1 15361857 24234451 25348397 association coimmunoprecipitation ComPPI,IntAct
MRPL9 EIF4G1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4G1 EIF4G1 16698552 24234451 physical association coimmunoprecipitation,x-ray crystallography IntAct
DICER1 EIF4G1 21858095 24234451 association anti tag coimmunoprecipitation IntAct
EIF4G1 ITPR2 24234451 30021884 physical association cross-linking study IntAct
EIF4G1 YLPM1 24234451 30021884 physical association cross-linking study IntAct
PRKCA EIF4G1 19415658 19691289 21576361 24248602 27898060 N/A N/A OmniPath
MAP3K8 EIF4G1 10654941 27898060 N/A N/A OmniPath
EIF4G1 TRAF2 15743837 27898060 N/A N/A OmniPath
MYC EIF4G1 18593934 27898060 stimulant N/A OmniPath
CASP3 EIF4G1 10611228 27898060 9819442 inhibition,stimulant N/A OmniPath
MAPK3 EIF4G1 23263986 27898060 N/A N/A OmniPath
ISG15 EIF4G1 16009940 27898060 N/A N/A OmniPath
PAK2 EIF4G1 16281055 17353931 27898060 inhibition N/A OmniPath
GSK3B EIF4G1 10654941 27898060 N/A N/A OmniPath
EIF4G1 EIF4E 10600798 10753870 12071973 15153109 16010989 16236269 16281055 16467844 16541103 16648488 16720573 17689282 18955708 20212144 21191102 22509910 22586265 23665581 26186194 26344197 27898060 7651417 8521827 9372926 9418880 stimulant N/A OmniPath
EIF4G1 MKNK1 15234964 27898060 9878069 N/A N/A OmniPath
MKNK1 EIF4G1 15234964 27898060 9878069 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B8291 EIF4G1 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return