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GENE：ELF3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ELF3
FullNmae E74 like ETS transcription factor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3318
EnsembleID ENSG00000163435
Uniprot P78545

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ELF3 cuproptosis 38462020 ELF3 transcriptionally activated SLC31A1 to trigger cuproptosis that drove cisplatin-induced AKI through mitochondrial dysfunction, indicating that SLC31A1 might be a promising therapeutic target to mitigate AKI during cisplatin chemotherapy. inducer

Go Annotation:

GeneSymbol Go id
ELF3 GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001824,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005794,GO:0005829,GO:0006357,GO:0006954,GO:0030154,GO:0030154,GO:0030198,GO:0045892,GO:0045944,GO:0060056,GO:1990837

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PAK1 ELF3 17491012 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay InnateDB
TGFBR2 ELF3 23180781 9417054 physical association electrophoretic mobility shift assay InnateDB
NFKB1 ELF3 11036073 23180781 physical association electrophoretic mobility supershift assay InnateDB
RELA ELF3 11036073 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 ELF3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 ELF3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ELF3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 ELF3 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 ELF3 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C ELF3 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ELF3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 ELF3 12746898 trascriptional regulation,stimulation inferred by curator TFlink
RELA ELF3 12746898 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000435A77 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000753AD ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000458AD2 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000011A030 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001BCAC5 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004CD810 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F3336 ELF3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKCI ELF3 22135298 phosphorylation N/A PhosphoSite
PAK1 ELF3 22135298 phosphorylation N/A PhosphoSite
EGFR ELF3 25361965 interaction type N/A PTMCode2
ELF3 EGFR 25361965 interaction type N/A PTMCode2
ERBB2 ELF3 25361965 interaction type N/A PTMCode2
ELF3 ERBB2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ISG15 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TAF9 ELF3 10821850 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2D1 ELF3 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
H2BC4 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KRT31 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK1 ELF3 25348397 N/A physical interaction ComPPI
TBP ELF3 25348397 N/A physical interaction ComPPI
JUN ELF3 14525934 1651323 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
AR ELF3 23435425 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CREBBP ELF3 14525934 15075319 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EP300 ELF3 14525934 15075319 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBE2D2 ELF3 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
BTRC ELF3 25348397 N/A physical interaction ComPPI
JAK1 ELF3 25348397 N/A physical interaction ComPPI
XRCC5 ELF3 25348397 N/A physical interaction ComPPI
CALR ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
P4HB ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MYC ELF3 14525934 1651323 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
XRCC6 ELF3 25348397 N/A physical interaction ComPPI
FSCN1 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EWSR1 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RELA ELF3 24234451 25348397 25926267 27898060 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
EPS15 ELF3 10064583 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
EGFR ELF3 14525934 1651322 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED23 ELF3 12242338 12708845 14525934 15025473 23464919 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PRKCI ELF3 24234451 25348397 26977885 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MSN ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PLA2G4A ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DDX3X ELF3 25348397 N/A physical interaction ComPPI
NFKB1 ELF3 11036073 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GARS1 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NUDC ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPL6 ELF3 25348397 N/A physical interaction ComPPI
PRKCSH ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GANAB ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ELF3 EHF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ELF3 TARS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ELF3 KRT82 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ELF3 AK6 25348397 N/A physical interaction ComPPI
ELF3 GADD45GIP1 19801644 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ELF3 KRT36 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 NLRC3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 PSMD6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 AKAP9 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 SPG7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 KCTD5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 KRT37 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 ETFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELF3 APBA3 24234451 25348397 26948053 physical association two hybrid ComPPI,IntAct
EEF1D ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CBR3 ELF3 25348397 N/A physical interaction ComPPI
ATIC ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KRTAP11-1 ELF3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
KDM5B ELF3 24234451 24937458 association chromatin immunoprecipitation assay IntAct
ELF3 NOTCH3 24234451 26977885 association chromatin immunoprecipitation assay IntAct
ELF3 COP1 19061637 26545401 27898060 N/A N/A OmniPath
ELF3 EGFR 1651322 27898060 N/A N/A OmniPath
ELF3 MYC 1651323 27898060 N/A N/A OmniPath
ELF3 NFKB1 11036073 23687337 27898060 N/A N/A OmniPath
ELF3 PAK1 17491012 27898060 N/A N/A OmniPath
PAK1 ELF3 17491012 27898060 stimulant N/A OmniPath

Visualization










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