Gene Information gene info

  1. Home

GENE：ELOB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ELOB
FullNmae elongin B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11619
EnsembleID ENSG00000103363
Uniprot Q15370

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ELOB cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ELOB GO:0001222,GO:0005515,GO:0005654,GO:0005829,GO:0006367,GO:0006368,GO:0016567,GO:0030891,GO:0031462,GO:0031466,GO:0031625,GO:0032436,GO:0065003,GO:0070449,GO:0070449,GO:0140958

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ELOB hsa:6923 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
ELOB hsa:6923 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
ELOB hsa:6923 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
ELOB hsa:6923 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ELOB hsa:6923 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SOCS4 ELOB 17997974 23180781 physical association x-ray crystallography InnateDB
ELOB SOCS3 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOB SPSB1 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOB SPSB2 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAB40C ELOB 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOB WSB1 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOB LRRC41 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOB VHL 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
LRR1 ELOB 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELOB FEM1B 15601820 23180781 physical association anti tag coimmunoprecipitation InnateDB
SOCS5 ELOB 15590694 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD9 ELOB 17936701 23180781 physical association gst pull down InnateDB
NEDD8 ELOB 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL5 ELOB 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB
CUL3 ELOB 21145461 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ELOB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ELOB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F4 ELOB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ELOB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ELOB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001F0C23 ELOB 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00005651EE ELOB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 ELOB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003AA845 ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 ELOB 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ORC1 ELOB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC73 ELOB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL5 ELOB 25348397 N/A pull down,physical interaction,physical interaction ComPPI
MAD2L2 ELOB 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
SOCS3 ELOB 10051596 14525934 15601820 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BCL2L11 ELOB 25348397 N/A physical interaction ComPPI
CDC42 ELOB 25348397 N/A physical interaction ComPPI
RBM3 ELOB 25348397 N/A physical interaction ComPPI
TP53BP1 ELOB 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
DCUN1D1 ELOB 25348397 N/A physical interaction ComPPI
KEAP1 ELOB 25348397 N/A physical interaction ComPPI
MCM2 ELOB 25348397 N/A physical interaction ComPPI
LAGE3 ELOB 25348397 N/A physical interaction ComPPI
MED8 ELOB 12149480 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,physical interaction ComPPI,IntAct
RACK1 ELOB 25348397 N/A physical interaction ComPPI
APPBP2 ELOB 25348397 N/A physical interaction ComPPI
RNF7 ELOB 25348397 N/A physical interaction ComPPI
SOCS1 ELOB 10051596 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
JUN ELOB 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HIF1A ELOB 12004076 12050673 17353276 24234451 25348397 physical association filter binding,isothermal titration calorimetry,surface plasmon resonance,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay ComPPI,IntAct
MYBBP1A ELOB 25348397 N/A physical interaction ComPPI
COPS5 ELOB 25348397 N/A physical interaction ComPPI
COP1 ELOB 25348397 N/A physical interaction ComPPI
RBX1 ELOB 12149480 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL3 ELOB 25348397 N/A physical interaction ComPPI
GHR ELOB 25348397 N/A physical interaction ComPPI
CSNK1E ELOB 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CISH ELOB 25348397 N/A physical interaction ComPPI
SOCS2 ELOB 25348397 N/A physical interaction ComPPI
CFTR ELOB 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PDLIM7 ELOB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SQSTM1 ELOB 25348397 N/A physical interaction ComPPI
CTR9 ELOB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPRS1 ELOB 25348397 N/A physical interaction ComPPI
ASB2 ELOB 14525934 15590664 19300455 21119685 24044920 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NEDD8 ELOB 25348397 N/A physical interaction ComPPI
CUL2 ELOB 15601820 19327355 24234451 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
EPOR ELOB 25348397 N/A physical interaction ComPPI
VHL ELOB 10205047 12004076 12050673 14525934 15601820 17353931 18323857 20871634 24234451 25348397 7660122 7660130 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
KLF4 ELOB 25348397 N/A physical interaction ComPPI
CEBPE ELOB 25348397 N/A physical interaction ComPPI
PFDN5 ELOB 25348397 N/A physical interaction ComPPI
NOS2 ELOB 25348397 N/A physical interaction ComPPI
COPS3 ELOB 25348397 N/A physical interaction ComPPI
COPS4 ELOB 25348397 N/A physical interaction ComPPI
COPS6 ELOB 25348397 N/A physical interaction ComPPI
ELOB ELOA 10587522 14525934 25348397 7660129 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOB SOCS6 12052866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOB LRRC41 11384984 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOB ELOA3P 11994304 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOB ASB8 12559969 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELOB ELOC 10205047 10587522 12004076 12050673 12149480 14525934 16189514 21516116 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
ELOB SAP130 25348397 N/A physical interaction ComPPI
ELOB ASB4 25348397 N/A physical interaction ComPPI
ELOB PAN2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB DIO2 25348397 N/A physical interaction ComPPI
ELOB ARNT 25348397 N/A physical interaction ComPPI
ELOB CORO7 21130766 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB UBXN7 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB ASB9 25348397 N/A physical interaction ComPPI
ELOB PRAME 21822215 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ELOB ZYG11B 25348397 N/A physical interaction ComPPI
ELOB ZER1 17304241 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ELOB PCMTD2 25348397 N/A physical interaction ComPPI
ELOB FEM1B 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB KLHDC2 25348397 N/A physical interaction ComPPI
ELOB KLHDC3 25348397 N/A physical interaction ComPPI
ELOB ASB1 25348397 N/A physical interaction ComPPI
ELOB ASB3 25348397 N/A physical interaction ComPPI
ELOB WSB1 25348397 N/A physical interaction ComPPI
ELOB RAB40B 25348397 N/A physical interaction ComPPI
ELOB KMT2A 25348397 N/A physical interaction ComPPI
ELOB OSGEP 25348397 N/A physical interaction ComPPI
ELOB LRR1 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB LRRC14 25348397 N/A physical interaction ComPPI
ELOB USP33 25348397 N/A physical interaction ComPPI
ELOB EPAS1 25348397 N/A physical interaction ComPPI
ELOB SPSB1 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB SPSB2 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB RAB40C 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB SPSB4 15601820 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB LARS1 25348397 N/A physical interaction ComPPI
ELOB LRRC47 25348397 N/A physical interaction ComPPI
ELOB ASB6 25348397 N/A physical interaction ComPPI
ELOB ASB7 25348397 N/A physical interaction ComPPI
ELOB ASB10 25348397 N/A physical interaction ComPPI
ELOB ASB12 25348397 N/A physical interaction ComPPI
ELOB MTMR8 25348397 N/A physical interaction ComPPI
ELOB ASB13 25348397 N/A physical interaction ComPPI
ELOB ASB14 25348397 N/A physical interaction ComPPI
ELOB ASB15 25348397 N/A physical interaction ComPPI
ELOB ASB17 25348397 N/A physical interaction ComPPI
ELOB ASB16 25348397 N/A physical interaction ComPPI
ELOB SOCS4 25348397 N/A physical interaction ComPPI
ELOB CBFB 25348397 N/A physical interaction ComPPI
ELOB AMBRA1 25348397 N/A physical interaction ComPPI
ELOB AP1S1 25348397 N/A physical interaction ComPPI
ELOB FAM50A 25348397 N/A physical interaction ComPPI
ELOB FERMT1 25348397 N/A physical interaction ComPPI
ELOB SEC31A 25348397 N/A physical interaction ComPPI
ELOB USP11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB SLC33A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB RGMA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB LDHD 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ELOB DCUN1D2 25348397 N/A physical interaction ComPPI
ELOB DCUN1D3 25348397 N/A physical interaction ComPPI
ELOB INTU 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ELOB TSC22D1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ELOB EPOP 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
ELOB HIF1AN 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ELOB CDK8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ELOB FBL 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ELOB SHLD3 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
ELOA2 ELOB 10692460 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NRBP1 ELOB 25348397 N/A physical interaction ComPPI
ARIH2 ELOB 24076655 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL53 ELOB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HIF-1 ELOB 12050673 24234451 physical association surface plasmon resonance IntAct
METTL3 ELOB 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 ELOB 24234451 29507755 association anti tag coimmunoprecipitation IntAct
SOCS3 ELOB 10051596 15601820 16007195 17135358 18590740 19385048 27898060 9869640 N/A N/A OmniPath
SOCS4 ELOB 17997974 19385048 27898060 N/A N/A OmniPath

Visualization










  Return