GENE：EPC2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EPC2 |
| FullNmae | enhancer of polycomb homolog 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:24543 |
| EnsembleID | ENSG00000135999 |
| Uniprot | Q52LR7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EPC2 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EPC2 | GO:0000786,GO:0005634,GO:0006281,GO:0006325,GO:0006357,GO:0032777,GO:0035267,GO:0042981,GO:0045893,GO:0051726,GO:1905168,GO:2000779 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EPC2 | hsa:26122 | path:hsa03082 | ATP-dependent chromatin remodeling - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | EPC2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | EPC2 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | EPC2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | EPC2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | EPC2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | EPC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000004203C | EPC2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000345DEB | EPC2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C7662 | EPC2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | EPC2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | EPC2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MORF4L2 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| MRGBP | EPC2 | 15647280 16230350 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| FOXR2 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPH2 | EPC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| EZH2 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| RUVBL1 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| MYC | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| KSR2 | EPC2 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MORF4L1 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| MED23 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| TRRAP | EPC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ACTL6A | EPC2 | 15647280 24234451 25348397 | association | affinity chromatography technology | ComPPI,IntAct |
| EED | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| DMAP1 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| YEATS4 | EPC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MAX | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| RUVBL2 | EPC2 | 16230350 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MEAF6 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| KAT5 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| VPS72 | EPC2 | 15647280 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ING3 | EPC2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MYCL | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| H2BC1 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| EP400 | EPC2 | 25348397 | N/A | physical interaction | ComPPI |
| EPC2 | PLAC1 | 25348397 | N/A | physical interaction | ComPPI |
| EPC2 | FOXR1 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| EPC2 | MBTD1 | 25348397 | N/A | physical interaction | ComPPI |
| MKI67 | EPC2 | 24234451 26949251 | association | anti tag coimmunoprecipitation | IntAct |