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GENE：FARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FARS2
FullNmae phenylalanyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21062
EnsembleID ENSG00000145982
Uniprot O95363

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
FARS2 GO:0000049,GO:0004826,GO:0004826,GO:0004826,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005739,GO:0005759,GO:0006418,GO:0006432,GO:0006432,GO:0008033

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FARS2 hsa:10667 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ISG15 FARS2 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
AR FARS2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 FARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FARS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FARS2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 FARS2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
FARS2 STX11 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRTAP10-5 24234451 25348397 25416956 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRTAP10-7 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 MKRN3 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRT31 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRT40 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 APPL1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 USP45 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 G3BP2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 ISG15 25348397 N/A physical interaction ComPPI
FARS2 CUL3 25348397 N/A physical interaction ComPPI
FARS2 RCBTB2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRT13 25348397 N/A physical interaction ComPPI
FARS2 TRIM27 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 TADA2A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 TFCP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 CALCOCO2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 MID2 25348397 N/A physical interaction ComPPI
FARS2 IKZF3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 ADAMTSL4 25348397 N/A physical interaction ComPPI
FARS2 AGTRAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 TRIM54 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 HMBOX1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 CMTM5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRTAP10-9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 KRTAP10-3 25348397 N/A physical interaction ComPPI
FARS2 NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FARS2 ENO1 25348397 N/A physical interaction ComPPI
FARS2 SHMT2 25348397 N/A physical interaction ComPPI
FARS2 NXF1 25348397 N/A physical interaction ComPPI
FARS2 H1-1 25348397 N/A physical interaction ComPPI
FARS2 ZC3H3 25348397 N/A physical interaction ComPPI
FARS2 HNRNPA1 25348397 N/A physical interaction ComPPI
FARS2 GAMT 25348397 N/A physical interaction ComPPI
FARS2 STAT5A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 TOMM40 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 CHST15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 NEDD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FARS2 CHCHD2 25348397 N/A physical interaction ComPPI
FARS2 MRPL38 25348397 N/A physical interaction ComPPI
FARS2 H1-4 25348397 N/A physical interaction ComPPI
FARS2 H1-6 25348397 N/A physical interaction ComPPI
FARS2 ZCRB1 25348397 N/A physical interaction ComPPI
FARS2 YBX1 23986595 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FARS2 TRIP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 MDFI 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 ZNF526 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 MESD 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 CDCA4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 DPH2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 DVL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 TRAF2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 MORN3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 SYP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 YIF1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 KRTAP3-3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 SPRY1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 FSD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 BEX5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 PPP1R16B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 NFKBID 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 ZNF500 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 KRTAP10-8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 MAN1C1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 ZNF438 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 CCDC152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 KCNF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 AJUBA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 ZRANB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 BACH2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 HIGD1C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 DGAT2L6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 KCTD17 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 RIMBP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 FKBP7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 ZNF655 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 FHL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 BAG4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FARS2 HSCB 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
FARS2 CISD3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CCT6A FARS2 24234451 30021884 physical association cross-linking study IntAct
ISG15 FARS2 16009940 27898060 N/A N/A OmniPath

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