GENE：FDXR
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FDXR |
| FullNmae | ferredoxin reductase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3642 |
| EnsembleID | ENSG00000161513 |
| Uniprot | P22570 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FDXR | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FDXR | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FDXR | cuproptosis | 36313717 | Proteins carrying iron-sulfur clusters are essential for the basic metabolism of all organisms. Eukaryotic iron-sulfur cluster assembly includes direct mitochondrial iron-sulfur cluster (ISC) co-assembly pathway and cytosolic iron-sulfur cluster assembly (CIA) pathway that uses active sulfur as substrate, these pathways containing protein complex (composed of cysteine desulfurase, a scaffold protein, auxiliary ISD11 protein, acyl carrier protein, frataxin, and ferredoxin), the related genes (including NFS1, ISD11, ACP1, ISCU2, FXN, FDX2, FDXR) and proteins of cytokine induced apoptosis inhibitor 1 (CIAPIN1), novel diflavin oxidoreductase 1 (NDOR1), nucleotide binding protein 2 (NUBP2), nucleotide binding protein 1 (NUBP1), iron-only hydrogenase-like protein 1 (IOP1), and Cytosolic iron-Sulfur assembly component 1 (CIAO1) | Proteins carrying iron-sulfur cluster |
| FDXR | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. | Genes of iron-sulfur cluster related proteins |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FDXR | GO:0004324,GO:0005739,GO:0005739,GO:0005743,GO:0005759,GO:0006091,GO:0006694,GO:0006744,GO:0008203,GO:0015039 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | FDXR | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | FDXR | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | FDXR | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | FDXR | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | FDXR | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | FDXR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | FDXR | 12370809 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP63 | FDXR | 12370809 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP73 | FDXR | 12370809 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | FDXR | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000EEE35 | FDXR | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000039A052 | FDXR | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000081E1F | FDXR | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000292B1 | FDXR | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00004B83FE | FDXR | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DCTN1 | FDXR | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| MTNR1A | FDXR | 25348397 | N/A | physical interaction | ComPPI |
| FHIT | FDXR | 25348397 | N/A | in vitro | ComPPI |
| OTC | FDXR | 25348397 | N/A | physical interaction | ComPPI |
| POU2F1 | FDXR | 25348397 | N/A | in vitro,in vivo | ComPPI |
| EMILIN1 | FDXR | 25348397 | N/A | physical interaction | ComPPI |
| GSR | FDXR | 25348397 | N/A | physical interaction | ComPPI |
| TMEM70 | FDXR | 25348397 | N/A | physical interaction | ComPPI |
| FDXR | FDX1 | 25348397 | N/A | in vitro | ComPPI |
| FDXR | A1BG | 25348397 | N/A | physical interaction | ComPPI |
| TP53 | FDXR | 12370809 27898060 | stimulant | N/A | OmniPath |