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GENE：FPGS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FPGS
FullNmae folylpolyglutamate synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3824
EnsembleID ENSG00000136877
Uniprot Q05932

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FPGS cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
FPGS GO:0001889,GO:0004326,GO:0004326,GO:0004326,GO:0005524,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0005829,GO:0006139,GO:0006536,GO:0006730,GO:0006760,GO:0031100,GO:0046655,GO:0046872,GO:0046901,GO:0046901,GO:0046901

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FPGS hsa:2356 path:hsa00790 Folate biosynthesis - Homo sapiens (human)
FPGS hsa:2356 path:hsa01100 Metabolic pathways - Homo sapiens (human)
FPGS hsa:2356 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
FPGS hsa:2356 path:hsa01523 Antifolate resistance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 FPGS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC FPGS 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C FPGS 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FPGS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FPGS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FPGS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FPGS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FPGS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FPGS 20072153 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FPGS 20072153 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C770D FPGS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 FPGS 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E2232 FPGS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000031B6ED FPGS 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000036AFF1 FPGS 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000032BDF4 FPGS 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 FPGS 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 FPGS 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 FPGS 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRIM25 FPGS 25348397 N/A physical interaction ComPPI
TOR1AIP2 FPGS 25348397 N/A physical interaction ComPPI
THEM4 FPGS 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009C2DE3 FPGS 27087310 direct interaction,inhibition N/A NPInter
URS00009BFE10 FPGS 27087310 direct interaction,inhibition N/A NPInter

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