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GENE：FZD8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FZD8
FullNmae frizzled class receptor 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4046
EnsembleID ENSG00000177283
Uniprot Q9H461

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FZD8 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
FZD8 GO:0001525,GO:0001934,GO:0004930,GO:0005102,GO:0005515,GO:0005794,GO:0005886,GO:0007186,GO:0016020,GO:0017147,GO:0030165,GO:0030182,GO:0031625,GO:0033077,GO:0035567,GO:0042813,GO:0042813,GO:0042813,GO:0060070,GO:0060070,GO:0060070,GO:0098992,GO:1990851

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FZD8 hsa:8325 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
FZD8 hsa:8325 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
FZD8 hsa:8325 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
FZD8 hsa:8325 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
FZD8 hsa:8325 path:hsa04916 Melanogenesis - Homo sapiens (human)
FZD8 hsa:8325 path:hsa04934 Cushing syndrome - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05010 Alzheimer disease - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05224 Breast cancer - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
FZD8 hsa:8325 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
WNT8A FZD8 10097073 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CTCF FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FZD8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 FZD8 23393589 23396279 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000ED600 FZD8 23393589 23396279 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001EFEC1 FZD8 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000237AF9 FZD8 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000031E12 FZD8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075994C FZD8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EBD4B FZD8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C FZD8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 FZD8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 FZD8 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 FZD8 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LRP5 FZD8 25361965 interaction type N/A PTMCode2
FZD8 LRP5 25361965 interaction type N/A PTMCode2
CTNNB1 FZD8 25361965 interaction type N/A PTMCode2
FZD8 CTNNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LRP5 FZD8 11448771 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SDCBP FZD8 18256285 24234451 25348397 N/A far western blotting ComPPI,IntAct
EPN1 FZD8 25348397 N/A physical interaction ComPPI
WNT3A FZD8 22682250 24234451 25348397 association,physical association pull down ComPPI,IntAct
GOPC FZD8 11520064 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
LRP6 FZD8 11029007 11448771 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FZD8 WNT1 14525934 15454084 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FZD8 UPK1A 25348397 N/A physical interaction ComPPI
FZD8 IPPK 25348397 N/A physical interaction ComPPI
FZD8 RYK 14525934 15454084 N/A experimental interaction detection HPRD
WNT2 FZD8 23815780 27898060 stimulant N/A OmniPath
WNT1 FZD8 11448771 15454084 27898060 stimulant N/A OmniPath
FZD8 LRP5 11448771 21078818 27898060 stimulant N/A OmniPath
FZD8 LRP6 11029007 11448771 15908424 21078818 27898060 stimulant N/A OmniPath
IGFBP4 FZD8 18528331 27898060 N/A N/A OmniPath
WNT5A FZD8 21518267 27898060 stimulant N/A OmniPath
WNT8A FZD8 10097073 27898060 stimulant N/A OmniPath
RYK FZD8 15454084 17035295 27898060 stimulant N/A OmniPath
WNT3A FZD8 22303445 22653731 22682250 27898060 stimulant N/A OmniPath
RSPO3 FZD8 16543246 27898060 N/A N/A OmniPath

Visualization










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