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GENE：GBF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GBF1
FullNmae golgi brefeldin A resistant guanine nucleotide exchange factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4181
EnsembleID ENSG00000107862
Uniprot Q92538

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GBF1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GBF1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GBF1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
GBF1 GO:0000139,GO:0002263,GO:0005085,GO:0005515,GO:0005547,GO:0005793,GO:0005794,GO:0005801,GO:0005802,GO:0005811,GO:0005829,GO:0006888,GO:0006890,GO:0006892,GO:0006895,GO:0007030,GO:0007346,GO:0015031,GO:0016020,GO:0030593,GO:0031252,GO:0032012,GO:0034067,GO:0042147,GO:0048205,GO:0060271,GO:0061162,GO:0070973,GO:0080025,GO:0090166,GO:0097111,GO:0098586,GO:1903409,GO:1903420,GO:2000008

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GBF1 hsa:8729 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GBF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 GBF1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 GBF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 GBF1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GBF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 GBF1 21512034 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000324096 GBF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA GBF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F GBF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 GBF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 GBF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 GBF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 GBF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A GBF1 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 GBF1 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 GBF1 22135298 phosphorylation N/A PhosphoSite
AURKB GBF1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 GBF1 25348397 N/A physical interaction ComPPI
VCP GBF1 25348397 N/A physical interaction ComPPI
FOXB1 GBF1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAG GBF1 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
KBTBD7 GBF1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXG1 GBF1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RAB8A GBF1 24234451 25348397 26824392 association anti tag coimmunoprecipitation ComPPI,IntAct
NUP85 GBF1 25348397 N/A physical interaction ComPPI
YWHAB GBF1 17353931 24234451 24255178 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRS4 GBF1 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC GBF1 25348397 N/A physical interaction ComPPI
NTRK1 GBF1 25348397 N/A physical interaction ComPPI
USO1 GBF1 12634853 24234451 25348397 27898060 colocalization two hybrid,fluorescence microscopy,in vitro,in vivo ComPPI,IntAct,OmniPath
BTRC GBF1 25348397 N/A physical interaction ComPPI
COPB1 GBF1 19039328 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PLEC GBF1 25348397 N/A physical interaction ComPPI
EPHA1 GBF1 25348397 N/A physical interaction ComPPI
PNPLA2 GBF1 25348397 N/A physical interaction ComPPI
EGFR GBF1 25348397 N/A physical interaction ComPPI
HDAC6 GBF1 25348397 N/A physical interaction ComPPI
TNFRSF1B GBF1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SRPK2 GBF1 25348397 N/A physical interaction ComPPI
COPG1 GBF1 19039328 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPS15L1 GBF1 25348397 N/A physical interaction ComPPI
FBXO7 GBF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC6 GBF1 25348397 N/A physical interaction ComPPI
FBXW11 GBF1 25348397 N/A physical interaction ComPPI
BET1 GBF1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GBF1 CCAR2 25348397 N/A physical interaction ComPPI
GBF1 NCAPH 25348397 N/A physical interaction ComPPI
GBF1 RABL6 25348397 N/A physical interaction ComPPI
GBF1 IVNS1ABP 25348397 N/A physical interaction ComPPI
GBF1 SPACA1 25348397 N/A physical interaction ComPPI
GBF1 PNKD 25348397 N/A physical interaction ComPPI
GBF1 LYPD3 25348397 N/A physical interaction ComPPI
GBF1 KIF4A 25348397 N/A physical interaction ComPPI
GBF1 PUS7 25348397 N/A physical interaction ComPPI
GBF1 RBM26 25348397 N/A physical interaction ComPPI
GBF1 VARS1 25348397 N/A physical interaction ComPPI
GBF1 ZSCAN26 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GBF1 FOXI2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
GBF1 FOXL1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
GBF1 PACC1 25348397 N/A physical interaction ComPPI
GBF1 CHRM3 25348397 N/A physical interaction ComPPI
GBF1 GML 25348397 N/A physical interaction ComPPI
GBF1 MILR1 25348397 N/A physical interaction ComPPI
GBF1 DLK2 25348397 N/A physical interaction ComPPI
GBF1 NPY2R 25348397 N/A physical interaction ComPPI
GBF1 PTP4A3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GBF1 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB GBF1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
GBF1 MROH2B 24234451 30021884 physical association cross-linking study IntAct
PRKAA1 GBF1 18063581 27898060 inhibition N/A OmniPath

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