GENE：GCLC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GCLC |
| FullNmae | glutamate-cysteine ligase catalytic subunit |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4311 |
| EnsembleID | ENSG00000001084 |
| Uniprot | P48506 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GCLC | pyroptosis | 36670138 | Furthermore, gasdermins, which regulate inflammatory form of cell death, were upregulated in the brains of GCLC-KO mice, suggesting the contribution of pyroptosis to neuronal cell death in these animals. | retulator signature |
| GCLC | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GCLC | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GCLC | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| GCLC | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GCLC | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GCLC | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GCLC | GO:0000287,GO:0004357,GO:0004357,GO:0004357,GO:0005515,GO:0005524,GO:0005739,GO:0005829,GO:0006534,GO:0006536,GO:0006750,GO:0006750,GO:0006750,GO:0006750,GO:0006979,GO:0007584,GO:0009408,GO:0009410,GO:0009725,GO:0014823,GO:0016595,GO:0017109,GO:0017109,GO:0019852,GO:0031397,GO:0032436,GO:0032869,GO:0035729,GO:0043066,GO:0043524,GO:0043531,GO:0044344,GO:0044752,GO:0044877,GO:0045454,GO:0045892,GO:0046685,GO:0046686,GO:0051409,GO:0051900,GO:0070555,GO:0071260,GO:0071333,GO:0071372,GO:0097069,GO:0097746,GO:1901029,GO:2000490,GO:2001237 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GCLC | hsa:2729 | path:hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
| GCLC | hsa:2729 | path:hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| GCLC | hsa:2729 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| GCLC | hsa:2729 | path:hsa01240 | Biosynthesis of cofactors - Homo sapiens (human) |
| GCLC | hsa:2729 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NFE2L2 | GCLC | 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19666106 19747488 23180781 23850759 26192618 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
| GCLC | JUN | 19666106 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EGR1 | GCLC | 19374776 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SP1 | GCLC | 19374776 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GCLC | POLR2F | 23180781 23994473 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GCLC | ELAVL1 | 19322201 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | GCLC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | GCLC | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | GCLC | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | GCLC | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| JUN | GCLC | 11233143 11912197 16054171 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| FOSL1 | GCLC | 11912197 16054171 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| FOXP3 | GCLC | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| NFE2L2 | GCLC | 16054171 18971253 22459801 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMARCA4 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | GCLC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUND | GCLC | 16054171 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MAF | GCLC | 16054171 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYT1 | GCLC | 15378601 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MTF1 | GCLC | 15378601 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFE2 | GCLC | 16054171 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | GCLC | 11233143 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | GCLC | 11233143 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | GCLC | 15342415 18245173 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | GCLC | 15342415 18245173 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | GCLC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | GCLC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000338542 | GCLC | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000005CF5F | GCLC | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | GCLC | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | GCLC | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | GCLC | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000024DFCE | GCLC | 25353619 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PAXIP1 | GCLC | 25348397 | N/A | physical interaction | ComPPI |
| CCL22 | GCLC | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ELAVL1 | GCLC | 25348397 | N/A | physical interaction | ComPPI |
| NMD3 | GCLC | 25348397 | N/A | physical interaction | ComPPI |
| PPID | GCLC | 25348397 | N/A | physical interaction | ComPPI |
| AGL | GCLC | 25348397 | N/A | physical interaction | ComPPI |
| GCLC | GCLM | 25348397 | N/A | physical interaction | ComPPI |
| GCLC | DHRS11 | 25348397 | N/A | physical interaction | ComPPI |
| GCLC | DPH5 | 25348397 | N/A | physical interaction | ComPPI |
| GCLC | TYW3 | 25348397 | N/A | physical interaction | ComPPI |
| PSIP1 | GCLC | 16403949 27898060 | stimulant | N/A | OmniPath |