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GENE：GPX4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GPX4
FullNmae glutathione peroxidase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4556
EnsembleID ENSG00000167468
Uniprot P36969

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GPX4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GPX4 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GPX4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GPX4 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GPX4 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
GPX4 GO:0004602,GO:0004602,GO:0005515,GO:0005634,GO:0005634,GO:0005635,GO:0005739,GO:0005829,GO:0005829,GO:0006325,GO:0006644,GO:0006749,GO:0006979,GO:0007283,GO:0008430,GO:0019369,GO:0019372,GO:0032355,GO:0032991,GO:0042759,GO:0042802,GO:0047066,GO:0047066,GO:0047066,GO:0047066,GO:0051258,GO:0070062,GO:0098869,GO:0110076

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GPX4 hsa:2879 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GPX4 hsa:2879 path:hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
GPX4 hsa:2879 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GPX4 hsa:2879 path:hsa04216 Ferroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GPX4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPE GPX4 17688422 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 GPX4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GPX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREM GPX4 15225122 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A GPX4 10428483 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GPX4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 GPX4 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PIN1 GPX4 25348397 N/A physical interaction ComPPI
NUTF2 GPX4 25348397 N/A physical interaction ComPPI
FKBP1A GPX4 25348397 N/A physical interaction ComPPI
JUN GPX4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
DUT GPX4 25348397 N/A physical interaction ComPPI
ENO1 GPX4 25348397 N/A physical interaction ComPPI
STIP1 GPX4 25348397 N/A physical interaction ComPPI
MAPK13 GPX4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VDAC1 GPX4 25348397 N/A physical interaction ComPPI
TAGLN GPX4 25348397 N/A physical interaction ComPPI
AKR1B1 GPX4 25348397 N/A physical interaction ComPPI
VDAC2 GPX4 25348397 N/A physical interaction ComPPI
FKBP2 GPX4 25348397 N/A physical interaction ComPPI
PRDX6 GPX4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ALDOC GPX4 25348397 N/A physical interaction ComPPI
TRIM25 GPX4 25348397 N/A physical interaction ComPPI
BIRC5 GPX4 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
SOD1 GPX4 25348397 N/A physical interaction ComPPI
UCHL3 GPX4 25348397 N/A physical interaction ComPPI
PPIF GPX4 25348397 N/A physical interaction ComPPI
EZR GPX4 25348397 N/A physical interaction ComPPI
ENO2 GPX4 25348397 N/A physical interaction ComPPI
HINT1 GPX4 25348397 N/A physical interaction ComPPI
PRDX2 GPX4 25348397 N/A physical interaction ComPPI
ENO3 GPX4 25348397 N/A physical interaction ComPPI
TKT GPX4 25348397 N/A physical interaction ComPPI
ALDOA GPX4 25348397 N/A physical interaction ComPPI
SOD2 GPX4 25348397 N/A physical interaction ComPPI
OTUD5 GPX4 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ETFB GPX4 25348397 N/A physical interaction ComPPI
TAGLN2 GPX4 25348397 N/A physical interaction ComPPI
OTUB1 GPX4 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GPX4 PPIB 24234451 30021884 physical association cross-linking study IntAct

Source Target Pmid Interactiontype Methods Database
URS00009AE4FD GPX4 27087310 direct interaction,inhibition N/A NPInter

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