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GENE：MAPKAPK5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAPKAPK5
FullNmae MAPK activated protein kinase 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6889
EnsembleID ENSG00000089022
Uniprot Q8IW41

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAPKAPK5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAPKAPK5 GO:0000165,GO:0002039,GO:0004674,GO:0004674,GO:0004674,GO:0004683,GO:0004708,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006417,GO:0007165,GO:0007265,GO:0007265,GO:0009931,GO:0018105,GO:0032007,GO:0032007,GO:0032156,GO:0032212,GO:0032991,GO:0046777,GO:0046777,GO:0051019,GO:0051973,GO:0060999,GO:0090398,GO:0090400,GO:0106310,GO:1901796,GO:1904355

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAPKAPK5 hsa:8550 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPKAPK5 MAPK13 23180781 9628874 phosphorylation reaction in-gel kinase assay InnateDB
MAPK12 MAPKAPK5 23180781 9628874 phosphorylation reaction in-gel kinase assay InnateDB
MAPK11 MAPKAPK5 23180781 23331499 9628874 phosphorylation reaction,stimulation in-gel kinase assay InnateDB,SignaLink
MAPKAPK5 MAPK14 11157753 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 MAPKAPK5 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB
MAPK14 MAPKAPK5 18988627 23331499 9628874 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
EIF4EBP1 MAPKAPK5 20005715 interaction type N/A PSP
EIF4EBP1 MAPKAPK5 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F4 MAPKAPK5 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MAPKAPK5 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 MAPKAPK5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAPKAPK5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D5391 MAPKAPK5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000047A67D MAPKAPK5 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F MAPKAPK5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 MAPKAPK5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C MAPKAPK5 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000E1E9E MAPKAPK5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003FA24D MAPKAPK5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 MAPKAPK5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0920 MAPKAPK5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000003FD55 MAPKAPK5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 MAPKAPK5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 MAPKAPK5 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F MAPKAPK5 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000058BB84 MAPKAPK5 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000075D1FC MAPKAPK5 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000272A92 MAPKAPK5 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000535FDD MAPKAPK5 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000007F792 MAPKAPK5 23313552 23824327 25416803 26701625 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 MAPKAPK5 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075C1E1 MAPKAPK5 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 MAPKAPK5 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000032AE90 MAPKAPK5 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00003E5ECC MAPKAPK5 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001FC26E MAPKAPK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 MAPKAPK5 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000013ABA3 MAPKAPK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000061E50F MAPKAPK5 23313552 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00000C85B2 MAPKAPK5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 MAPKAPK5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 MAPKAPK5 23313552 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000076E54 MAPKAPK5 23313552 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000006372A MAPKAPK5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 MAPKAPK5 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MAPKAPK5 19536157 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC0F4 MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075D50C MAPKAPK5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 MAPKAPK5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 MAPKAPK5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237AF9 MAPKAPK5 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 MAPKAPK5 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 MAPKAPK5 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00003380CC MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000315338 MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C0FCB MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F31F4 MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C11BC MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000251D0B MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000048D44E MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000221168 MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001DC1D3 MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000031602A MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000CC005 MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027464B MAPKAPK5 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000100748 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001C770D MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002152A8 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000019907A MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000137EDE MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075A760 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000118224 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004283FE MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000D2680 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000008AA34 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000043D2C1 MAPKAPK5 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK11 MAPKAPK5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKACA MAPKAPK5 22135298 phosphorylation N/A PhosphoSite
MAPK14 MAPKAPK5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 MAPKAPK5 22135298 phosphorylation N/A PhosphoSite
MAPKAPK5 SEPTIN8 22135298 phosphorylation N/A PhosphoSite
MAPKAPK5 KALRN 22135298 phosphorylation N/A PhosphoSite
MAPKAPK5 DNAJB1 22135298 phosphorylation N/A PhosphoSite
MAPKAPK5 TP53 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPKAPK5 RHEB 22135298 phosphorylation N/A PhosphoSite
MAPK9 MAPKAPK5 22135298 phosphorylation N/A PhosphoSite
MAPKAPK5 MAPK13 25361965 interaction type N/A PTMCode2
MAPK13 MAPKAPK5 25361965 interaction type N/A PTMCode2
MAPKAPK5 MAPK14 25361965 interaction type N/A PTMCode2
MAPKAPK5 HSPB1 25361965 interaction type N/A PTMCode2
HSPB1 MAPKAPK5 25361965 interaction type N/A PTMCode2
MAPKAPK5 MAPK6 25361965 interaction type N/A PTMCode2
MAPK6 MAPKAPK5 25361965 interaction type N/A PTMCode2
TP53 MAPKAPK5 25361965 interaction type N/A PTMCode2
MAPKAPK5 MAPK11 25361965 interaction type N/A PTMCode2
MAPKAPK5 PLA2G4A 25361965 interaction type N/A PTMCode2
PLA2G4A MAPKAPK5 25361965 interaction type N/A PTMCode2
MAPKAPK5 JUN 25361965 interaction type N/A PTMCode2
JUN MAPKAPK5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK9 MAPKAPK5 14525934 24234451 25241761 25348397 9628874 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
ZNF576 MAPKAPK5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK1 MAPKAPK5 14525934 24234451 25241761 25348397 9628874 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
JUN MAPKAPK5 14525934 25348397 9628874 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK5 MAPK14 14525934 20936779 24234451 25348397 9628874 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro ComPPI,HPRD,IntAct
MAPKAPK5 MAPK12 14525934 25348397 9628874 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPKAPK5 MAPK11 25348397 N/A in vitro ComPPI
MAPKAPK5 EEF2K 12171600 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK5 PLA2G4A 10978317 14525934 25348397 8636128 9468497 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPKAPK5 HSPB1 14525934 21575178 24234451 25348397 9628874 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro ComPPI,HPRD,IntAct
MAPKAPK5 MAPK13 14525934 25348397 9628874 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPKAPK5 MAPK4 14525934 18720373 23602568 24234451 25348397 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
MAPKAPK5 EIF4E 14525934 25348397 9628874 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK5 GYS1 14525934 25348397 9628874 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK5 MBP 14525934 25348397 9628874 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK5 MYH11 14525934 25348397 9628874 N/A experimental interaction detection,in vitro ComPPI,HPRD
MAPKAPK5 HSPB2 25348397 N/A physical interaction ComPPI
MAPKAPK5 RPL13 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPKAPK5 ZNF282 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPKAPK5 TAB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPKAPK5 MAPKAPK2 25348397 N/A physical interaction ComPPI
MAPKAPK5 LSR 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPKAPK5 CDCA8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPKAPK5 SRPK2 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
MAPKAPK5 SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
MAPKAPK5 TP53 14525934 17254968 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay ComPPI,HPRD,IntAct
MAPKAPK5 STK40 25348397 N/A physical interaction ComPPI
EIF4EBP1 MAPKAPK5 14525934 24234451 25241761 25348397 9628874 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
MAPK6 MAPKAPK5 14525934 18720373 20936779 21900206 23602568 24234451 25348397 25416956 26972000 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,tandem affinity purification,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
PKM MAPKAPK5 25348397 N/A protein kinase assay ComPPI
ATF2 MAPKAPK5 14525934 25348397 9628874 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPD1 MAPKAPK5 24234451 30021884 physical association cross-linking study IntAct
PRKACA MAPKAPK5 20734105 27898060 N/A N/A OmniPath
MAPK9 MAPKAPK5 25241761 27898060 9628874 N/A N/A OmniPath
MAPKAPK5 FOXO3 17711846 21329882 27898060 N/A N/A OmniPath
MAPK13 MAPKAPK5 27898060 9628874 stimulant N/A OmniPath
TLR4 MAPKAPK5 24489676 27898060 N/A N/A OmniPath
MAPKAPK5 RHEB 21336308 27898060 N/A N/A OmniPath
MAPKAPK5 TP53 10606744 11042698 11314044 11865061 14712210 15381073 16501611 17254968 18568040 26029824 27898060 9363941 9925639 stimulant N/A OmniPath
MAPK14 MAPKAPK5 11157753 18669648 20936779 27898060 9628874 stimulant N/A OmniPath
MAPKAPK5 DNAJB1 24309468 27898060 stimulant N/A OmniPath
MAPK1 MAPKAPK5 21666810 25241761 27898060 9628874 stimulant N/A OmniPath
ISG15 MAPKAPK5 16009940 27898060 N/A N/A OmniPath
MAPK11 MAPKAPK5 18669648 19690332 27898060 9628874 stimulant N/A OmniPath
MAPK12 MAPKAPK5 27898060 9628874 stimulant N/A OmniPath
MAPKAPK5 PLA2G4A 10978317 16964243 18212344 18669648 19664994 20068231 27898060 8636128 9468497 stimulant N/A OmniPath
MAPKAPK5 TH 12421349 19801645 27898060 stimulant N/A OmniPath
MAPKAPK5 MAPK4 1319925 18720373 21675959 23602568 27898060 stimulant N/A OmniPath
MAPKAPK5 KALRN 22508986 27898060 N/A N/A OmniPath
MAPKAPK5 SEPTIN8 22649572 27898060 N/A N/A OmniPath

Visualization










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