We retrieved 21 genes involved in Cuproptosis from the literature, including CDKN2A, DLD, DLAT, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, and PDHB, ATB7B, CUTC, GRX1, MT1A, MT2A, MT3, XIAP, ATM, PRNP, P53, and SP1.
ATP7B and GRX1 excrete excess copper ions out of the mitochondria. CUTC directly binds Cu2+ while XIAP passivates and hydrolyzes caspase after binding Cu2+ to inhibit Cuproptosis.
