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GENE：GTPBP4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GTPBP4
FullNmae GTP binding protein 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21535
EnsembleID ENSG00000107937
Uniprot Q9BZE4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GTPBP4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GTPBP4 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
GTPBP4 GO:0000079,GO:0000463,GO:0001649,GO:0003723,GO:0003723,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0005730,GO:0005737,GO:0005829,GO:0008156,GO:0008285,GO:0016020,GO:0022408,GO:0030336,GO:0031397,GO:0031965,GO:0033342,GO:0042273,GO:0042273,GO:0048471,GO:0050821,GO:1990275

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GTPBP4 hsa:23560 path:hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GTPBP4 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
OAS3 GTPBP4 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF2AK2 GTPBP4 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
SUZ12 GTPBP4 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 GTPBP4 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 GTPBP4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GTPBP4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC GTPBP4 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 GTPBP4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GTPBP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 GTPBP4 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 GTPBP4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001DA458 GTPBP4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E5ECC GTPBP4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C GTPBP4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000279B6F GTPBP4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA GTPBP4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 GTPBP4 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000006A1CB GTPBP4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000239117 GTPBP4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0874 GTPBP4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 GTPBP4 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RSL24D1 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 RSL24D1 25361965 interaction type N/A PTMCode2
PES1 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 PES1 25361965 interaction type N/A PTMCode2
GTPBP4 GNL2 25361965 interaction type N/A PTMCode2
GNL2 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 EIF6 25361965 interaction type N/A PTMCode2
EIF6 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 MRTO4 25361965 interaction type N/A PTMCode2
MRTO4 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 PAK1IP1 25361965 interaction type N/A PTMCode2
PAK1IP1 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 NOP2 25361965 interaction type N/A PTMCode2
NOP2 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 NLE1 25361965 interaction type N/A PTMCode2
NLE1 GTPBP4 25361965 interaction type N/A PTMCode2
SDAD1 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 SDAD1 25361965 interaction type N/A PTMCode2
NMD3 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 NMD3 25361965 interaction type N/A PTMCode2
EBNA1BP2 GTPBP4 25361965 interaction type N/A PTMCode2
GTPBP4 EBNA1BP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 GTPBP4 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CBX8 GTPBP4 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NPM1 GTPBP4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL37A GTPBP4 25348397 N/A physical interaction ComPPI
ZBTB48 GTPBP4 25348397 N/A physical interaction ComPPI
GABARAPL2 GTPBP4 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NOL12 GTPBP4 25348397 N/A physical interaction ComPPI
YWHAG GTPBP4 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KEAP1 GTPBP4 25348397 N/A physical interaction ComPPI
NIFK GTPBP4 25348397 N/A physical interaction ComPPI
TBL3 GTPBP4 25348397 N/A physical interaction ComPPI
RRS1 GTPBP4 25348397 N/A physical interaction ComPPI
GNL3L GTPBP4 25348397 N/A physical interaction ComPPI
RPL10A GTPBP4 25348397 N/A physical interaction ComPPI
PNMA2 GTPBP4 25348397 N/A physical interaction ComPPI
NF2 GTPBP4 17210637 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct,OmniPath
RPL10 GTPBP4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FGF3 GTPBP4 25348397 N/A physical interaction ComPPI
JUN GTPBP4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 GTPBP4 25348397 N/A physical interaction ComPPI
RPL18A GTPBP4 25348397 N/A physical interaction ComPPI
RBM4 GTPBP4 25348397 N/A physical interaction ComPPI
NTRK1 GTPBP4 25348397 N/A physical interaction ComPPI
YBX1 GTPBP4 24234451 25348397 25497084 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF2AK2 GTPBP4 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU GTPBP4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDX5 GTPBP4 25348397 N/A physical interaction ComPPI
EIF6 GTPBP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EEA1 GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKRA GTPBP4 25348397 N/A physical interaction ComPPI
RPS6 GTPBP4 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
RPL4 GTPBP4 25348397 N/A physical interaction ComPPI
CSNK2A2 GTPBP4 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RAB11A GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PINX1 GTPBP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF2 GTPBP4 25348397 N/A physical interaction ComPPI
CEBPZ GTPBP4 25348397 N/A physical interaction ComPPI
CDK7 GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
WDR12 GTPBP4 25348397 N/A physical interaction ComPPI
ZRSR2 GTPBP4 25348397 N/A physical interaction ComPPI
VCAM1 GTPBP4 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
EED GTPBP4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UTP14A GTPBP4 25348397 N/A physical interaction ComPPI
AZGP1 GTPBP4 25348397 N/A physical interaction ComPPI
MECP2 GTPBP4 25348397 N/A physical interaction ComPPI
RAB9A GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MYO6 GTPBP4 25348397 N/A physical interaction ComPPI
CUL7 GTPBP4 25348397 N/A physical interaction ComPPI
H3C1 GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CAND1 GTPBP4 25348397 N/A physical interaction ComPPI
SART3 GTPBP4 25348397 N/A physical interaction ComPPI
TRIM25 GTPBP4 25348397 N/A physical interaction ComPPI
PSME3 GTPBP4 25348397 N/A physical interaction ComPPI
NOP56 GTPBP4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRPK2 GTPBP4 25348397 N/A physical interaction ComPPI
ILF2 GTPBP4 25348397 N/A physical interaction ComPPI
ESR1 GTPBP4 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
ESR2 GTPBP4 21182203 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
RPL6 GTPBP4 25348397 N/A physical interaction ComPPI
TGOLN2 GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
POP1 GTPBP4 25348397 N/A physical interaction ComPPI
NMD3 GTPBP4 25348397 N/A physical interaction ComPPI
AURKAIP1 GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
AURKB GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BET1 GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IFI16 GTPBP4 25348397 N/A physical interaction ComPPI
RPL14 GTPBP4 25348397 N/A physical interaction ComPPI
PES1 GTPBP4 25348397 N/A physical interaction ComPPI
DICER1 GTPBP4 25348397 N/A physical interaction ComPPI
RRP1B GTPBP4 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SUZ12 GTPBP4 25348397 N/A physical interaction ComPPI
MED20 GTPBP4 25348397 N/A physical interaction ComPPI
DGCR8 GTPBP4 25348397 N/A physical interaction ComPPI
MPHOSPH10 GTPBP4 25348397 N/A physical interaction ComPPI
IMP3 GTPBP4 25348397 N/A physical interaction ComPPI
DDX56 GTPBP4 25348397 N/A physical interaction ComPPI
KIF11 GTPBP4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PWP1 GTPBP4 25348397 N/A physical interaction ComPPI
CDX1 GTPBP4 25348397 N/A physical interaction ComPPI
RPS14 GTPBP4 25348397 N/A physical interaction ComPPI
UTP3 GTPBP4 25348397 N/A physical interaction ComPPI
DKC1 GTPBP4 25348397 N/A physical interaction ComPPI
MTF1 GTPBP4 25348397 N/A physical interaction ComPPI
DDX24 GTPBP4 25348397 N/A physical interaction ComPPI
LYAR GTPBP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL36 GTPBP4 25348397 N/A physical interaction ComPPI
NOC2L GTPBP4 25348397 N/A physical interaction ComPPI
FBL GTPBP4 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FGF8 GTPBP4 25348397 N/A physical interaction ComPPI
RPL30 GTPBP4 25348397 N/A physical interaction ComPPI
H1-1 GTPBP4 25348397 N/A physical interaction ComPPI
GTPBP4 TP53 25348397 N/A physical interaction ComPPI
GTPBP4 OAS3 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTPBP4 SIRT7 25348397 N/A physical interaction ComPPI
GTPBP4 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
GTPBP4 IFRD1 25348397 N/A physical interaction ComPPI
GTPBP4 KCTD2 25348397 N/A physical interaction ComPPI
GTPBP4 MRTO4 25348397 N/A physical interaction ComPPI
GTPBP4 STAU1 25348397 N/A physical interaction ComPPI
GTPBP4 OBSL1 25348397 N/A physical interaction ComPPI
GTPBP4 NSA2 12808088 16861225 25348397 26186194 26344197 27898060 N/A physical interaction ComPPI,OmniPath
GTPBP4 ZC3H3 25348397 N/A physical interaction ComPPI
GTPBP4 BRIX1 25348397 N/A physical interaction ComPPI
GTPBP4 DDX47 25348397 N/A physical interaction ComPPI
GTPBP4 DDX55 25348397 N/A physical interaction ComPPI
GTPBP4 NOP53 25348397 N/A physical interaction ComPPI
GTPBP4 GNL2 25348397 N/A physical interaction ComPPI
GTPBP4 GRWD1 25348397 N/A physical interaction ComPPI
GTPBP4 DDX18 25348397 N/A physical interaction ComPPI
GTPBP4 PUM3 25348397 N/A physical interaction ComPPI
GTPBP4 MRPL2 25348397 N/A physical interaction ComPPI
GTPBP4 NOP58 25348397 N/A physical interaction ComPPI
GTPBP4 POLR1C 25348397 N/A physical interaction ComPPI
GTPBP4 WDR3 25348397 N/A physical interaction ComPPI
GTPBP4 NOP2 25348397 N/A physical interaction ComPPI
GTPBP4 RPF2 25348397 N/A physical interaction ComPPI
GTPBP4 RPL27 25348397 N/A physical interaction ComPPI
GTPBP4 SDAD1 25348397 N/A physical interaction ComPPI
GTPBP4 WDR36 25348397 N/A physical interaction ComPPI
GTPBP4 CNBP 25348397 N/A physical interaction ComPPI
GTPBP4 RBM34 25348397 N/A physical interaction ComPPI
GTPBP4 RPL18 25348397 N/A physical interaction ComPPI
GTPBP4 RRP8 25348397 N/A physical interaction ComPPI
GTPBP4 MAGEB10 25348397 N/A physical interaction ComPPI
GTPBP4 ZNF692 25348397 N/A physical interaction ComPPI
GTPBP4 ZNF512 25348397 N/A physical interaction ComPPI
GTPBP4 PPAN 11864607 16651379 18559667 19737519 19797079 23045392 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GTPBP4 ZC3HAV1 25348397 N/A physical interaction ComPPI
GTPBP4 SRP68 25348397 N/A physical interaction ComPPI
GTPBP4 H1-6 25348397 N/A physical interaction ComPPI
GTPBP4 ZNF2 25348397 N/A physical interaction ComPPI
GTPBP4 WDR46 25348397 N/A physical interaction ComPPI
GTPBP4 MAK16 25348397 N/A physical interaction ComPPI
GTPBP4 LLGL2 25348397 N/A physical interaction ComPPI
GTPBP4 MACROH2A2 25348397 N/A physical interaction ComPPI
GTPBP4 NCL 25348397 N/A physical interaction ComPPI
GTPBP4 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
GTPBP4 MNDA 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
EBNA1BP2 GTPBP4 25348397 N/A physical interaction ComPPI
MKI67 GTPBP4 24234451 26949251 association anti tag coimmunoprecipitation IntAct
PREB GTPBP4 24234451 30021884 physical association cross-linking study IntAct
PRKDC GTPBP4 24234451 30021884 physical association cross-linking study IntAct
DNAI7 GTPBP4 22083961 27898060 N/A N/A OmniPath

Visualization










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