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GENE：CASP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP2
FullNmae caspase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1503
EnsembleID ENSG00000106144
Uniprot P42575

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP2 mitotic_cd 19730412 The apoptotic initiator caspase-2 has been implicated in oocyte death, in DNA damage- and heat shock-induced death, and in mitotic catastrophe. retulator signature
CASP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP2 GO:0001554,GO:0003407,GO:0004197,GO:0004197,GO:0005515,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006915,GO:0006915,GO:0006919,GO:0006974,GO:0006977,GO:0008630,GO:0008630,GO:0016485,GO:0019899,GO:0019904,GO:0035234,GO:0042802,GO:0043065,GO:0043065,GO:0043066,GO:0043525,GO:0071260,GO:0097190,GO:0097192,GO:0097194,GO:0097199,GO:0097200,GO:1905369,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP2 hsa:835 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CASP2 CASP2 19337385 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR CASP2 16007156 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 CASP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CASP2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 CASP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CASP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX3 CASP2 17956589 trascriptional regulation,stimulation inferred by curator TFlink
XPC CASP2 22174370 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 CASP2 22473208 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00004505E4 CASP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C0FCB CASP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FF9C CASP2 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA CASP2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F CASP2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 CASP2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 CASP2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 CASP2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 CASP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE CASP2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000019D79B CASP2 23568547 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000045B99E CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD CASP2 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 CASP2 25416803 26962687 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 CASP2 22135298 phosphorylation N/A PhosphoSite
PRKDC CASP2 22135298 phosphorylation N/A PhosphoSite
BCL2L1 CASP2 25361965 interaction type N/A PTMCode2
CASP2 BCL2L1 25361965 interaction type N/A PTMCode2
CASP2 BID 25361965 interaction type N/A PTMCode2
BID CASP2 25361965 interaction type N/A PTMCode2
CASP2 BCL2 25361965 interaction type N/A PTMCode2
BCL2 CASP2 25361965 interaction type N/A PTMCode2
CASP2 PIDD1 25361965 interaction type N/A PTMCode2
PIDD1 CASP2 25361965 interaction type N/A PTMCode2
CASP2 XIAP 25361965 interaction type N/A PTMCode2
XIAP CASP2 25361965 interaction type N/A PTMCode2
CASP2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP2 25361965 interaction type N/A PTMCode2
NOL3 CASP2 25361965 interaction type N/A PTMCode2
CASP2 NOL3 25361965 interaction type N/A PTMCode2
CASP7 CASP2 25361965 interaction type N/A PTMCode2
CASP2 CASP7 25361965 interaction type N/A PTMCode2
CASP3 CASP2 25361965 interaction type N/A PTMCode2
CASP2 CASP3 25361965 interaction type N/A PTMCode2
GOLGA3 CASP2 25361965 interaction type N/A PTMCode2
CASP2 GOLGA3 25361965 interaction type N/A PTMCode2
TNFRSF1A CASP2 25361965 interaction type N/A PTMCode2
CASP2 TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 CASP2 12477715 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
HNRNPK CASP2 25348397 N/A physical interaction ComPPI
UBE2I CASP2 25348397 N/A physical interaction ComPPI
CRYAB CASP2 25348397 N/A physical interaction ComPPI
CASP2 ADCYAP1 11350957 11972030 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
CASP2 CASP7 11399776 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP2 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP2 GOLGA3 10791974 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP2 CRADD 11156409 11832478 14525934 15073321 16652156 24234451 25348397 25416956 27107012 8985253 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CASP2 NOL3 14525934 25348397 9560245 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP2 CASP14 14525934 25348397 9792675 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP2 NOD1 10329646 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP2 DCTN1 11425872 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CASP2 NLRP1 11076957 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP2 PIDD1 14525934 15073321 16652156 24234451 25348397 colocalization,association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
CASP2 CSNK2A1 14525934 16193064 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP2 CFLAR 14525934 25348397 9228018 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP2 RB1 14525934 15735701 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP2 MZB1 11350957 11972030 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CASP2 CCND3 12011445 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP2 DSP 14525934 15500642 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP2 CASP3 25348397 N/A physical interaction ComPPI
CASP2 BID 11832478 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CASP2 CASP8 25348397 N/A physical interaction ComPPI
CASP2 TNFRSF1A 25348397 N/A physical interaction ComPPI
CASP2 MDM2 21726810 24234451 25348397 protein cleavage physical interaction,protease assay ComPPI,IntAct
CASP2 RAI1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP2 EEF1A1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP2 EEF1A1P5 25348397 N/A physical interaction ComPPI
CASP2 RXRA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP2 GRB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP2 ELAVL1 25348397 N/A physical interaction ComPPI
CASP2 SUMO1 25348397 N/A physical interaction ComPPI
CASP2 BIRC2 25348397 N/A physical interaction ComPPI
CASP2 RPL30 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP2 EPN3 25348397 N/A physical interaction ComPPI
CASP2 PRKAB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP2 BAG4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BBOX1 CASP2 25348397 N/A physical interaction ComPPI
CASP2 CASP2 14525934 22531785 24234451 25416956 26871637 9261102 physical association experimental interaction detection,two hybrid array,bimolecular fluorescence complementation,two hybrid prey pooling approach,validated two hybrid HPRD,IntAct
CASP2 TRAF2 15590671 27898060 stimulant N/A OmniPath
CASP3 CASP2 11399776 18723680 27898060 9261102 9922454 stimulant N/A OmniPath
CASP2 BID 11399776 11832478 16495337 27898060 stimulant N/A OmniPath
CRADD CASP2 11156409 11832478 15073321 16652156 23049853 25416956 27898060 8985253 9695946 stimulant N/A OmniPath
PIDD1 CASP2 15073321 16360037 16652156 21415862 27898060 stimulant N/A OmniPath
CASP2 CYCS 11832478 27898060 stimulant N/A OmniPath
CASP2 AIFM1 11832478 27898060 stimulant N/A OmniPath
CASP2 CASP8 11832478 15262979 16193064 27898060 8962078 stimulant N/A OmniPath
PPP1CB CASP2 19531356 27898060 N/A N/A OmniPath
CASP2 GOLGA3 10791974 27898060 inhibition N/A OmniPath
AR CASP2 16007156 27898060 inhibition N/A OmniPath
BIRC2 CASP2 16701639 27898060 inhibition N/A OmniPath
PPP1CA CASP2 19531356 27898060 N/A N/A OmniPath
CSNK2A1 CASP2 16193064 27898060 inhibition N/A OmniPath
CASP2 RIPK1 15590671 27898060 stimulant N/A OmniPath
CASP2 DIABLO 11832478 27898060 stimulant N/A OmniPath
PRKDC CASP2 19203584 27898060 stimulant N/A OmniPath
PPP1CC CASP2 19531356 27898060 N/A N/A OmniPath

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