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GENE：HARS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HARS2
FullNmae histidyl-tRNA synthetase 2, mitochondrial
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4817
EnsembleID ENSG00000112855
Uniprot P49590

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HARS2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
HARS2 GO:0003723,GO:0003723,GO:0004821,GO:0004821,GO:0004821,GO:0004821,GO:0005515,GO:0005524,GO:0005739,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006418,GO:0006427,GO:0006427,GO:0042802,GO:0042802

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HARS2 hsa:23438 path:hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HARS2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HARS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE HARS2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
ORC1 HARS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP1 HARS2 25348397 N/A physical interaction ComPPI
AGTRAP HARS2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AURKA HARS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDK1 HARS2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GORASP1 HARS2 25348397 N/A physical interaction ComPPI
SARS2 HARS2 25348397 N/A physical interaction ComPPI
CD79A HARS2 25348397 N/A physical interaction ComPPI
NDUFS7 HARS2 25348397 N/A physical interaction ComPPI
OTC HARS2 25348397 N/A physical interaction ComPPI
PRKAB1 HARS2 25348397 N/A physical interaction ComPPI
SHMT2 HARS2 25348397 N/A physical interaction ComPPI
HSPD1 HARS2 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GTF2H5 HARS2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FUS HARS2 25348397 N/A physical interaction ComPPI
SLC25A10 HARS2 25348397 N/A physical interaction ComPPI
MRPL12 HARS2 25348397 N/A physical interaction ComPPI
SDHB HARS2 25348397 N/A physical interaction ComPPI
NXF1 HARS2 25348397 N/A physical interaction ComPPI
MOV10 HARS2 25348397 N/A physical interaction ComPPI

Visualization










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