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GENE：HCCS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HCCS
FullNmae holocytochrome c synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4837
EnsembleID ENSG00000004961
Uniprot P53701

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HCCS cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
HCCS GO:0004408,GO:0004408,GO:0005515,GO:0005739,GO:0005739,GO:0005743,GO:0005829,GO:0009887,GO:0016020,GO:0018063,GO:0018063,GO:0020037,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HCCS hsa:3052 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
HCCS hsa:3052 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HCCS 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 HCCS 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HCCS 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF HCCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HCCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HCCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HCCS 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002C0FCB HCCS 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00003380CC HCCS 21750653 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00003BBF48 HCCS 20371350 25416803 27292025 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000DDD35 HCCS 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000065FDF HCCS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD HCCS 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000C73C HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000308E4D HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006F90B HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D1FC HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000085F64 HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000CC005 HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EEE35 HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000012930C HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000058BB84 HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000049FAE8 HCCS 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RAB14 HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
FZR1 HCCS 25348397 N/A physical interaction ComPPI
SNX1 HCCS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MPZL1 HCCS 25348397 N/A physical interaction ComPPI
RAB2A HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PLIN3 HCCS 25348397 N/A physical interaction ComPPI
ELAVL1 HCCS 25348397 N/A physical interaction ComPPI
CIDEB HCCS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SENP2 HCCS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ASCC3 HCCS 25348397 N/A physical interaction ComPPI
MRPL17 HCCS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COMT HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SNX20 HCCS 25348397 N/A physical interaction ComPPI
IFNA1 HCCS 25348397 N/A physical interaction ComPPI
AIFM1 HCCS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CRTC3 HCCS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NPAT HCCS 25348397 N/A physical interaction ComPPI
COX4I1 HCCS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CYC1 HCCS 25348397 N/A physical interaction ComPPI
AGK HCCS 25348397 N/A physical interaction ComPPI
MYCL HCCS 25348397 N/A physical interaction ComPPI
SFXN1 HCCS 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX6B1 HCCS 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TMX1 HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MRRF HCCS 25348397 N/A physical interaction ComPPI
RDH11 HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RAB21 HCCS 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HCCS NDUFA4 25348397 N/A physical interaction ComPPI
HCCS SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

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