Gene Information gene info

  1. Home

GENE：HMBS

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMBS
FullNmae hydroxymethylbilane synthase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4982
EnsembleID ENSG00000256269
Uniprot P08397

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMBS autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMBS cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
HMBS GO:0004418,GO:0004418,GO:0005515,GO:0005737,GO:0005829,GO:0006782,GO:0006783,GO:0006783,GO:0006783

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HMBS hsa:3145 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
HMBS hsa:3145 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HMBS hsa:3145 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HMBS 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 HMBS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HMBS 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC HMBS 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 HMBS 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SP1 HMBS N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000C85B2 HMBS 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PICK1 HMBS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDIA3 HMBS 25348397 N/A physical interaction ComPPI
EWSR1 HMBS 25348397 N/A physical interaction ComPPI
RANBP9 HMBS 12917623 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
ZDHHC17 HMBS 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XPO7 HMBS 24234451 25348397 29748336 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SAR1A HMBS 25348397 N/A physical interaction ComPPI
HNRNPA1 HMBS 25348397 N/A physical interaction ComPPI
TP53I3 HMBS 25348397 N/A physical interaction ComPPI
HMBS APP 25348397 N/A physical interaction ComPPI
HMBS YTHDF2 25348397 N/A physical interaction ComPPI

Visualization










  Return