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GENE：HSPH1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HSPH1
FullNmae heat shock protein family H (Hsp110) member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16969
EnsembleID ENSG00000120694
Uniprot Q92598

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HSPH1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HSPH1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HSPH1 cuproptosis 36550822 Next, 11 hub CAGs(cuproptosis-associated genes), including COPB2, MRPL39, PGK1, PRDX1, PCMT1, MPZL3, LACTB2, HSPH1, DIP2B, DLG3, and NFKBIA, were applied to construct a novel prognostic risk signature for BR. cuproptosis-associated gene

Go Annotation:

GeneSymbol Go id
HSPH1 GO:0000774,GO:0000774,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005874,GO:0006457,GO:0006986,GO:0032991,GO:0043014,GO:0045345,GO:0051085,GO:0051135,GO:0070062,GO:0071682,GO:0140662

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HSPH1 hsa:10808 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HSPH1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 HSPH1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HSPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HSPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HSPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HSPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HSPH1 18971253 20188076 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HSPH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 HSPH1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
HSPA8 HSPH1 25361965 interaction type N/A PTMCode2
HSPH1 HSPA8 25361965 interaction type N/A PTMCode2
CSNK2A1 HSPH1 25361965 interaction type N/A PTMCode2
HSPH1 CSNK2A1 25361965 interaction type N/A PTMCode2
CSNK2A2 HSPH1 25361965 interaction type N/A PTMCode2
HSPH1 CSNK2A2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI HSPH1 25348397 N/A physical interaction ComPPI
HSPA8 HSPH1 14525934 24234451 25036637 25348397 26344197 27898060 29568061 9675148 association experimental interaction detection,pull down,physical interaction,in vivo,proximity-dependent biotin identification ComPPI,HPRD,IntAct,OmniPath
HSPA2 HSPH1 24234451 25036637 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
CFL1 HSPH1 14525934 14733918 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SET HSPH1 25348397 N/A physical interaction ComPPI
GABARAPL2 HSPH1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TP53BP2 HSPH1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MCM2 HSPH1 25348397 N/A physical interaction ComPPI
MAP1LC3B HSPH1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSP90AB1 HSPH1 16263121 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
H4C1 HSPH1 25348397 N/A physical interaction ComPPI
NF2 HSPH1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB2 HSPH1 25348397 N/A physical interaction ComPPI
BLNK HSPH1 25348397 N/A physical interaction ComPPI
VAV2 HSPH1 18654987 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP1R15A HSPH1 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN HSPH1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
USP7 HSPH1 25348397 N/A physical interaction ComPPI
U2AF2 HSPH1 25348397 N/A physical interaction ComPPI
CUL3 HSPH1 25348397 N/A physical interaction ComPPI
YWHAZ HSPH1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
DLD HSPH1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSP90AA1 HSPH1 25348397 N/A physical interaction ComPPI
NTRK1 HSPH1 25348397 N/A physical interaction ComPPI
FAF1 HSPH1 25348397 N/A physical interaction ComPPI
ILK HSPH1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STIP1 HSPH1 25348397 N/A physical interaction ComPPI
HSPA5 HSPH1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYC HSPH1 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PARVA HSPH1 25348397 N/A physical interaction ComPPI
CSNK2A1 HSPH1 10772927 12558502 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TUBA4A HSPH1 12749852 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CFTR HSPH1 25348397 N/A physical interaction ComPPI
MAPK6 HSPH1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NFATC2 HSPH1 25348397 N/A physical interaction ComPPI
RELA HSPH1 25348397 N/A tandem affinity purification ComPPI
RDX HSPH1 25348397 N/A physical interaction ComPPI
PAFAH1B1 HSPH1 14525934 14733918 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HUWE1 HSPH1 25348397 N/A physical interaction ComPPI
CSNK2A2 HSPH1 10772927 12558502 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TUBA1A HSPH1 24234451 25348397 27291054 association pull down ComPPI,IntAct
NR4A1 HSPH1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HSPA4 HSPH1 25348397 N/A physical interaction ComPPI
YAP1 HSPH1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GABARAP HSPH1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MAP1LC3A HSPH1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPH1 PGK1 14525934 14733918 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HSPH1 UBA1 14525934 14733918 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HSPH1 ADD1 14525934 14733918 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HSPH1 DYNLRB1 25348397 N/A physical interaction ComPPI
HSPH1 STK39 25348397 N/A physical interaction ComPPI
HSPH1 CHD3 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HSPH1 TERF1 25348397 N/A physical interaction ComPPI
HSPH1 TERF2 25348397 N/A physical interaction ComPPI
HSPH1 ZBTB7B 25348397 N/A physical interaction ComPPI
HSPH1 HSP90AA2P 25348397 N/A physical interaction ComPPI
HSPH1 NOS2 25348397 N/A physical interaction ComPPI
HSPH1 METTL21A 25348397 N/A physical interaction ComPPI
HSPH1 FBXO6 25348397 N/A physical interaction ComPPI
HSPH1 TARDBP 25348397 N/A physical interaction ComPPI
HSPH1 HECW2 25348397 N/A physical interaction ComPPI
HSPH1 HIRIP3 25348397 N/A physical interaction ComPPI
HSPH1 CARM1 25348397 N/A physical interaction ComPPI
HSPH1 CTNNA1 25348397 N/A physical interaction ComPPI
HSPH1 DPYSL2 25348397 N/A physical interaction ComPPI
HSPH1 FARSB 25348397 N/A physical interaction ComPPI
HSPH1 PLOD2 25348397 N/A physical interaction ComPPI
HSPH1 PPM1G 25348397 N/A physical interaction ComPPI
HSPH1 PUS7 25348397 N/A physical interaction ComPPI
HSPH1 SAMHD1 25348397 N/A physical interaction ComPPI
HSPH1 SEC23A 25348397 N/A physical interaction ComPPI
HSPH1 UGP2 25348397 N/A physical interaction ComPPI
HSPH1 USP11 25348397 N/A physical interaction ComPPI
HSPH1 PRMT3 25348397 N/A physical interaction ComPPI
HSPH1 RANBP3 25348397 N/A physical interaction ComPPI
HSPH1 SF1 25348397 N/A physical interaction ComPPI
HSPH1 BUB1B 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPH1 RPS6KB2 25348397 N/A physical interaction ComPPI
HSPH1 CCT2 25348397 N/A physical interaction ComPPI
HSPH1 DNAJA1 25348397 N/A physical interaction ComPPI
HSPH1 DNAJA2 25348397 N/A physical interaction ComPPI
HSPH1 DNAJA4 25348397 N/A physical interaction ComPPI
HSPH1 DNAJB1 25348397 N/A physical interaction ComPPI
HSPH1 DNAJB4 25348397 N/A physical interaction ComPPI
HSPH1 DNAJC3 25348397 N/A physical interaction ComPPI
HSPH1 CPS1 25348397 N/A physical interaction ComPPI
HSPH1 DNAJC17 25348397 N/A physical interaction ComPPI
HSPH1 EZR 25348397 N/A physical interaction ComPPI
HSPH1 GRPEL1 25348397 N/A physical interaction ComPPI
HSPH1 HSPE1 25348397 N/A physical interaction ComPPI
HSPH1 MSN 25348397 N/A physical interaction ComPPI
HSPH1 PREP 25348397 N/A physical interaction ComPPI
HSPH1 PSMB5 25348397 N/A physical interaction ComPPI
HSPH1 TAGLN2 25348397 N/A physical interaction ComPPI
HSPH1 TAGLN3 25348397 N/A physical interaction ComPPI
HSPH1 USP39 25348397 N/A physical interaction ComPPI
HSPH1 CEP104 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HSPH1 STIL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HSPH1 ZNF207 25348397 N/A physical interaction ComPPI
HSPH1 CYLD 25348397 N/A physical interaction ComPPI
HSPH1 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HSPH1 EDEM3 25348397 N/A physical interaction ComPPI
HSPH1 ESR1 25348397 N/A physical interaction ComPPI
HSPH1 BRCA1 25348397 N/A physical interaction ComPPI
HSPH1 ATXN3 25348397 N/A physical interaction ComPPI
HSPH1 MAP3K1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSPH1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPH1 MEX3C 22863774 24234451 25348397 association pull down ComPPI,IntAct
HSPH1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPH1 TUBB3 24234451 25348397 27291054 association pull down ComPPI,IntAct
HSPH1 PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
HSPH1 PHLPP2 24234451 25348397 28330616 association pull down ComPPI,IntAct
HSPA9 HSPH1 25348397 N/A physical interaction ComPPI
ASS1 HSPH1 25348397 N/A physical interaction ComPPI
PAFAH1B3 HSPH1 25348397 N/A physical interaction ComPPI
XPO7 HSPH1 25348397 N/A physical interaction ComPPI
ATF2 HSPH1 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN23 HSPH1 24234451 25348397 28330616 association pull down ComPPI,IntAct
METTL3 HSPH1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
MAPT HSPH1 24234451 26402096 association anti bait coimmunoprecipitation IntAct

Visualization










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