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GENE：IDH1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IDH1
FullNmae isocitrate dehydrogenase (NADP(+)) 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5382
EnsembleID ENSG00000138413
Uniprot O75874

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IDH1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IDH1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
IDH1 cuproptosis 36324575 TCA and copper malnutrition-related genes (CDKN2A, IDH1, OGDHL, IDH3G, IDH3B, GLS, DLAT, LIPT1)聽were finally included. copper malnutrition-related genes

Go Annotation:

GeneSymbol Go id
IDH1 GO:0000287,GO:0004450,GO:0004450,GO:0005515,GO:0005576,GO:0005737,GO:0005739,GO:0005777,GO:0005777,GO:0005782,GO:0005829,GO:0005829,GO:0005829,GO:0006097,GO:0006099,GO:0006102,GO:0006102,GO:0006103,GO:0006739,GO:0006749,GO:0006979,GO:0008585,GO:0034774,GO:0042802,GO:0042803,GO:0045296,GO:0048545,GO:0050661,GO:0051287,GO:0060696,GO:0070062,GO:0071071,GO:1904724,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IDH1 hsa:3417 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
IDH1 hsa:3417 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
IDH1 hsa:3417 path:hsa01100 Metabolic pathways - Homo sapiens (human)
IDH1 hsa:3417 path:hsa01200 Carbon metabolism - Homo sapiens (human)
IDH1 hsa:3417 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
IDH1 hsa:3417 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
IDH1 hsa:3417 path:hsa04146 Peroxisome - Homo sapiens (human)
IDH1 hsa:3417 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 IDH1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IDH1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IDH1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C IDH1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IDH1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IDH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 IDH1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS0000237AF9 IDH1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002971AB IDH1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
GLRX3 IDH1 25348397 N/A physical interaction ComPPI
PCBP1 IDH1 25348397 N/A physical interaction ComPPI
NUP62 IDH1 25348397 N/A physical interaction ComPPI
UBL7 IDH1 25348397 N/A physical interaction ComPPI
FHL2 IDH1 25348397 N/A physical interaction ComPPI
SLC2A4 IDH1 25348397 N/A physical interaction ComPPI
NTRK1 IDH1 25348397 N/A physical interaction ComPPI
IDH2 IDH1 11042198 16884682 18313953 19645416 19750512 21133413 21861471 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDH1 IDH1 25348397 N/A physical interaction ComPPI
NME1 IDH1 25348397 N/A physical interaction ComPPI
RANBP1 IDH1 25348397 N/A physical interaction ComPPI
CDK2 IDH1 25348397 N/A physical interaction ComPPI
ZHX1 IDH1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PHB2 IDH1 25348397 N/A physical interaction ComPPI
LAX1 IDH1 25348397 N/A physical interaction ComPPI
FDPS IDH1 25348397 N/A physical interaction ComPPI
IDH3A IDH1 25348397 N/A physical interaction ComPPI
IDH3G IDH1 25348397 N/A physical interaction ComPPI
IDH3B IDH1 25348397 N/A physical interaction ComPPI
ASF1B IDH1 25348397 N/A physical interaction ComPPI
ELAVL1 IDH1 25348397 N/A physical interaction ComPPI
UBE2H IDH1 25348397 N/A physical interaction ComPPI
ARF4 IDH1 25348397 N/A physical interaction ComPPI
CAB39 IDH1 25348397 N/A physical interaction ComPPI
RCN1 IDH1 25348397 N/A physical interaction ComPPI
CHMP4A IDH1 25348397 N/A physical interaction ComPPI
DAZAP1 IDH1 25348397 N/A physical interaction ComPPI
SUGT1 IDH1 25348397 N/A physical interaction ComPPI
AGGF1 IDH1 25348397 N/A physical interaction ComPPI
AK2 IDH1 25348397 N/A physical interaction ComPPI
ADSS2 IDH1 25348397 N/A physical interaction ComPPI
MDH2 IDH1 25348397 N/A physical interaction ComPPI
NME2 IDH1 25348397 N/A physical interaction ComPPI
TKT IDH1 25348397 N/A physical interaction ComPPI
IDH1 AK1 25348397 N/A physical interaction ComPPI
IDH1 PEX5 25348397 N/A physical interaction ComPPI
IDH1 ANXA6 25348397 N/A physical interaction ComPPI
IDH1 CBX3 25348397 N/A physical interaction ComPPI
IDH1 DCK 25348397 N/A physical interaction ComPPI
IDH1 EFHD2 25348397 N/A physical interaction ComPPI
IDH1 OXCT1 25348397 N/A physical interaction ComPPI
IDH1 SBDS 25348397 N/A physical interaction ComPPI
IDH1 PTMS 25348397 N/A physical interaction ComPPI
IDH1 RBBP7 25348397 N/A physical interaction ComPPI
IDH1 MOV10 25348397 N/A physical interaction ComPPI
IDH1 NXF1 25348397 N/A physical interaction ComPPI
IDH1 HSD17B4 25348397 N/A physical interaction ComPPI
IDH1 ETHE1 25348397 N/A physical interaction ComPPI
IDH1 LTA4H 25348397 N/A physical interaction ComPPI
IDH1 CEP57L1 21516116 24234451 25348397 physical association two hybrid ComPPI,IntAct
IDH1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
IDH1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct

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