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GENE：IDH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IDH2
FullNmae isocitrate dehydrogenase (NADP(+)) 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5383
EnsembleID ENSG00000182054
Uniprot P48735

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IDH2 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
IDH2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
IDH2 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
IDH2 GO:0000287,GO:0004450,GO:0004450,GO:0004450,GO:0004450,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0005975,GO:0006097,GO:0006099,GO:0006102,GO:0006103,GO:0006739,GO:0051287,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IDH2 hsa:3418 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
IDH2 hsa:3418 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
IDH2 hsa:3418 path:hsa01100 Metabolic pathways - Homo sapiens (human)
IDH2 hsa:3418 path:hsa01200 Carbon metabolism - Homo sapiens (human)
IDH2 hsa:3418 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
IDH2 hsa:3418 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)
IDH2 hsa:3418 path:hsa04146 Peroxisome - Homo sapiens (human)
IDH2 hsa:3418 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ADRB2 IDH2 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 IDH2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 IDH2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IDH2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C IDH2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000345DEB IDH2 23263745 rna interference,inhibition quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000345DEB IDH2 23263745 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 IDH2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000239117 IDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000166778 IDH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 IDH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E IDH2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 IDH2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IDH2 FH 25361965 interaction type N/A PTMCode2
FH IDH2 25361965 interaction type N/A PTMCode2
IDH2 IDH3B 25361965 interaction type N/A PTMCode2
IDH3B IDH2 25361965 interaction type N/A PTMCode2
IDH3G IDH2 25361965 interaction type N/A PTMCode2
IDH2 IDH3G 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNRPB2 IDH2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
FASTKD3 IDH2 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KEAP1 IDH2 25348397 N/A physical interaction ComPPI
KBTBD7 IDH2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SND1 IDH2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
JUN IDH2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF5B IDH2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PDIA3 IDH2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SLC2A4 IDH2 14525934 16396496 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBE2N IDH2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NTRK1 IDH2 25348397 N/A physical interaction ComPPI
IDH2 CDK2 25348397 N/A physical interaction ComPPI
IDH2 HDAC1 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IDH2 ADRB2 25348397 N/A physical interaction ComPPI
IDH2 PYGL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IDH2 EGFR 25348397 N/A physical interaction ComPPI
IDH2 KCMF1 25348397 N/A physical interaction ComPPI
IDH2 IDH1 11042198 16884682 18313953 19645416 19750512 21133413 21861471 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IDH2 G6PD 25348397 N/A physical interaction ComPPI
IDH2 IDH3A 25348397 N/A physical interaction ComPPI
IDH2 IDH3B 25348397 N/A physical interaction ComPPI
IDH2 IDH3G 25348397 N/A physical interaction ComPPI
IDH2 ZNF746 25348397 N/A physical interaction ComPPI
IDH2 SLC39A9 25348397 N/A physical interaction ComPPI
IDH2 GLMP 25348397 N/A physical interaction ComPPI
IDH2 MAS1 25348397 N/A physical interaction ComPPI
IDH2 SLC15A1 25348397 N/A physical interaction ComPPI
IDH2 PA2G4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 TRAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 ANXA5 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 GPI 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 MRPL12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 SLC25A10 25348397 N/A physical interaction ComPPI
IDH2 CRNN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 ZNF207 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
IDH2 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IDH2 CFTR 25348397 N/A physical interaction ComPPI
IDH2 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
IDH2 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
IDH2 COQ2 24234451 25348397 29128334 association cross-linking study ComPPI,IntAct
HSCB IDH2 24234451 25348397 28380382 association anti tag coimmunoprecipitation ComPPI,IntAct
SIRT3 IDH2 22416140 27898060 stimulant N/A OmniPath

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