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GENE：IDH3A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IDH3A
FullNmae isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5384
EnsembleID ENSG00000166411
Uniprot P50213

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IDH3A cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
IDH3A GO:0000287,GO:0004449,GO:0004449,GO:0005515,GO:0005634,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005962,GO:0005975,GO:0006099,GO:0006099,GO:0006102,GO:0051287

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IDH3A hsa:3419 path:hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
IDH3A hsa:3419 path:hsa01100 Metabolic pathways - Homo sapiens (human)
IDH3A hsa:3419 path:hsa01200 Carbon metabolism - Homo sapiens (human)
IDH3A hsa:3419 path:hsa01210 2-Oxocarboxylic acid metabolism - Homo sapiens (human)
IDH3A hsa:3419 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 IDH3A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IDH3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IDH3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IDH3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IDH3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005DEC41 IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001310DE IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000081D1E IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000519450 IDH3A 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RAB4A IDH3A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RPN1 IDH3A 25348397 N/A physical interaction ComPPI
PPP2R1A IDH3A 25348397 N/A physical interaction ComPPI
FASTKD3 IDH3A 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
KEAP1 IDH3A 25348397 N/A physical interaction ComPPI
S100A16 IDH3A 25348397 N/A physical interaction ComPPI
ACTN4 IDH3A 25348397 N/A physical interaction ComPPI
DLD IDH3A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBE2N IDH3A 25348397 N/A physical interaction ComPPI
IDH2 IDH3A 25348397 N/A physical interaction ComPPI
CANX IDH3A 25348397 N/A physical interaction ComPPI
MYC IDH3A 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
CAD IDH3A 25348397 N/A physical interaction ComPPI
CFTR IDH3A 25348397 N/A physical interaction ComPPI
NFATC2 IDH3A 25348397 N/A physical interaction ComPPI
EPRS1 IDH3A 25348397 N/A physical interaction ComPPI
PSMC5 IDH3A 25348397 N/A physical interaction ComPPI
HUWE1 IDH3A 25348397 N/A physical interaction ComPPI
RPLP0 IDH3A 25348397 N/A physical interaction ComPPI
ADRB2 IDH3A 25348397 N/A physical interaction ComPPI
EGFR IDH3A 25348397 N/A physical interaction ComPPI
PSMD2 IDH3A 25348397 N/A physical interaction ComPPI
UQCRC2 IDH3A 25348397 N/A physical interaction ComPPI
ATP2B1 IDH3A 25348397 N/A physical interaction ComPPI
IDH3A IDH3G 10677231 14525934 14555658 24234451 25348397 28098230 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,ion exchange chromatography,reverse phase chromatography,in vivo ComPPI,HPRD,IntAct
IDH3A IDH3B 10601238 14525934 25348397 N/A experimental interaction detection,physical interaction,ion exchange chromatography,in vitro,in vivo ComPPI,HPRD
IDH3A SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IDH3A DMWD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IDH3A PSMD4 25348397 N/A physical interaction ComPPI
IDH3A TERF1 25348397 N/A physical interaction ComPPI
IDH3A TERF2 25348397 N/A physical interaction ComPPI
IDH3A SUCLA2 25348397 N/A physical interaction ComPPI
IDH3A MBNL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IDH3A STAU1 25348397 N/A physical interaction ComPPI
IDH3A CUL7 25348397 N/A physical interaction ComPPI
IDH3A RDH13 25348397 N/A physical interaction ComPPI
IDH3A ABCC1 25348397 N/A physical interaction ComPPI
IDH3A ABCC3 25348397 N/A physical interaction ComPPI
IDH3A ACO2 25348397 N/A physical interaction ComPPI
IDH3A CCT8 25348397 N/A physical interaction ComPPI
IDH3A PUDP 25348397 N/A physical interaction ComPPI
IDH3A IDH1 25348397 N/A physical interaction ComPPI
IDH3A ACADM 25348397 N/A physical interaction ComPPI
IDH3A CCT6A 25348397 N/A physical interaction ComPPI
IDH3A CCT6B 25348397 N/A physical interaction ComPPI
IDH3A CLTCL1 25348397 N/A physical interaction ComPPI
IDH3A CS 25348397 N/A physical interaction ComPPI
IDH3A ETFA 25348397 N/A physical interaction ComPPI
IDH3A MDH2 25348397 N/A physical interaction ComPPI
IDH3A RPLP0P6 25348397 N/A physical interaction ComPPI
IDH3A SLC25A3 25348397 N/A physical interaction ComPPI
IDH3A SUCLG2 25348397 N/A physical interaction ComPPI
IDH3A IPO9 25348397 N/A physical interaction ComPPI
IDH3A SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IDH3A SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
IDH3A IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
IDH3A PDK1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 IDH3A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DDA1 IDH3A 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSCB IDH3A 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
FU IDH3A 15710747 24234451 25348397 physical association physical interaction,two hybrid fragment pooling approach ComPPI,IntAct

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