Gene Information gene info

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GENE：INTS6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol INTS6
FullNmae integrator complex subunit 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14879
EnsembleID ENSG00000102786
Uniprot Q9UL03

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
INTS6 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
INTS6 GO:0004888,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0015629,GO:0016180,GO:0016180,GO:0032039,GO:0032039,GO:0032039,GO:0034243,GO:0034472

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BMI1 INTS6 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 INTS6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A INTS6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 INTS6 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 INTS6 20584899 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection TarBase
URS0000065D58 INTS6 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000B59A2 INTS6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 INTS6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D INTS6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000015F70F INTS6 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
POLR2C INTS6 25361965 interaction type N/A PTMCode2
INTS6 POLR2C 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L INTS6 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CTDSP2 INTS6 25348397 N/A physical interaction ComPPI
POLR2L INTS6 25348397 N/A physical interaction ComPPI
PPP2R1A INTS6 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP1CB INTS6 25348397 N/A physical interaction ComPPI
BMI1 INTS6 25348397 N/A physical interaction ComPPI
OLFM4 INTS6 25348397 N/A physical interaction ComPPI
EIF4G1 INTS6 17469741 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ZMYND8 INTS6 25348397 N/A physical interaction ComPPI
NTRK1 INTS6 25348397 N/A physical interaction ComPPI
RPA1 INTS6 25348397 N/A physical interaction ComPPI
LRP1 INTS6 25348397 N/A physical interaction ComPPI
PPP2CB INTS6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PROZ INTS6 25348397 N/A physical interaction ComPPI
HNRNPL INTS6 25348397 N/A physical interaction ComPPI
PPP2CA INTS6 24234451 25348397 26496610 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ZNF592 INTS6 25348397 N/A physical interaction ComPPI
RPA2 INTS6 25348397 N/A physical interaction ComPPI
RPA3 INTS6 25348397 N/A physical interaction ComPPI
UPF2 INTS6 17469741 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CTDP1 INTS6 25348397 N/A physical interaction ComPPI
POLR2E INTS6 25348397 N/A physical interaction ComPPI
POLR2A INTS6 25348397 N/A physical interaction ComPPI
UPF1 INTS6 17469741 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SEM1 INTS6 25348397 N/A physical interaction ComPPI
TRIM25 INTS6 25348397 N/A physical interaction ComPPI
NCBP1 INTS6 17469741 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PPP2R1B INTS6 25348397 N/A physical interaction ComPPI
EIF4E INTS6 17469741 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF3A INTS6 17469741 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
POLR2J INTS6 25348397 N/A physical interaction ComPPI
POLR2C INTS6 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
POLR2G INTS6 25348397 N/A physical interaction ComPPI
SHMT2 INTS6 25348397 N/A physical interaction ComPPI
POLR2D INTS6 25348397 N/A physical interaction ComPPI
MCM7 INTS6 17310990 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
POLR2H INTS6 25348397 N/A physical interaction ComPPI
POLR2B INTS6 25348397 N/A physical interaction ComPPI
INTS11 INTS6 25348397 N/A physical interaction ComPPI
DDX24 INTS6 25348397 N/A physical interaction ComPPI
INTS13 INTS6 25348397 N/A physical interaction ComPPI
INTS1 INTS6 25348397 N/A physical interaction ComPPI
C7ORF26 INTS6 25348397 N/A physical interaction ComPPI
INTS9 INTS6 25348397 N/A physical interaction ComPPI
INTS4 INTS6 25348397 N/A physical interaction ComPPI
INTS10 INTS6 25348397 N/A physical interaction ComPPI
SEM1 INTS6 25348397 N/A physical interaction ComPPI
NXF1 INTS6 25348397 N/A physical interaction ComPPI
MOV10 INTS6 25348397 N/A physical interaction ComPPI
E2F3 INTS6 22157815 24234451 25348397 association pull down ComPPI,IntAct
INTS7 INTS6 25348397 N/A physical interaction ComPPI
INTS3 INTS6 25348397 N/A physical interaction ComPPI
INTS6L INTS6 25348397 N/A physical interaction ComPPI
INTS2 INTS6 25348397 N/A physical interaction ComPPI
INTS5 INTS6 25348397 N/A physical interaction ComPPI
INTS6 INTS8 25348397 N/A physical interaction ComPPI
INTS6 INTS12 25348397 N/A physical interaction ComPPI
INTS6 INTS14 25348397 N/A physical interaction ComPPI
INTS6 NAIF1 25348397 N/A physical interaction ComPPI
INTS6 NABP2 25348397 N/A physical interaction ComPPI
INTS6 ZNF687 25348397 N/A physical interaction ComPPI
INTS6 SCARA3 25348397 N/A physical interaction ComPPI
INTS6 NABP1 25348397 N/A physical interaction ComPPI
INTS6 TBL1Y 25348397 N/A physical interaction ComPPI
INTS6 BBS7 25348397 N/A physical interaction ComPPI
COS INTS6 15710747 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct

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