Gene Information gene info

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GENE：ISCA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ISCA1
FullNmae iron-sulfur cluster assembly 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28660
EnsembleID ENSG00000135070
Uniprot Q9BUE6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ISCA1 cuproptosis 38150993 Our recent paper demonstrated that human ISCA1, ISCA2 and ISCU proteins harbor strong copper-binding activity, which would impair Fe–S assembly. cuproptosis-related genes
ISCA1 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins

Go Annotation:

GeneSymbol Go id
ISCA1 GO:0005515,GO:0005737,GO:0005739,GO:0005759,GO:0016226,GO:0046872,GO:0051537,GO:0097428

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ISCA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ISCA1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ISCA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ISCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ISCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ISCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ISCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ISCA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000018C928 ISCA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000037E170 ISCA1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 ISCA1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 ISCA1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000031BC7D ISCA1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 ISCA1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 ISCA1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000042619A ISCA1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LZTS2 ISCA1 25348397 N/A physical interaction ComPPI
RIN1 ISCA1 25348397 N/A physical interaction ComPPI
PDIA6 ISCA1 25348397 N/A physical interaction ComPPI
CSH1 ISCA1 25348397 N/A physical interaction ComPPI
CSH2 ISCA1 25348397 N/A physical interaction ComPPI
TRIB1 ISCA1 25348397 N/A physical interaction ComPPI
GORASP2 ISCA1 25348397 N/A physical interaction ComPPI
TRAF2 ISCA1 25348397 N/A physical interaction ComPPI
RGS3 ISCA1 25348397 N/A physical interaction ComPPI
PDK1 ISCA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ELAVL1 ISCA1 25348397 N/A physical interaction ComPPI
HSPB9 ISCA1 25348397 N/A physical interaction ComPPI
TRIB2 ISCA1 25348397 N/A physical interaction ComPPI
GH2 ISCA1 25348397 N/A physical interaction ComPPI
GCDH ISCA1 25348397 N/A physical interaction ComPPI
ISCA1 RAB40A 25348397 N/A physical interaction ComPPI
ISCA1 RAB40B 25348397 N/A physical interaction ComPPI

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