Gene Information gene info

  1. Home

GENE：ISCA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ISCA2
FullNmae iron-sulfur cluster assembly 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19857
EnsembleID ENSG00000165898
Uniprot Q86U28

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ISCA2 cuproptosis 38150993 Our recent paper demonstrated that human ISCA1, ISCA2 and ISCU proteins harbor strong copper-binding activity, which would impair Fe–S assembly. cuproptosis-related genes
ISCA2 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
ISCA2 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins
ISCA2 cuproptosis 36118866 FeS Cluster cuproptosis gene
ISCA2 cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
ISCA2 cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
ISCA2 GO:0005506,GO:0005515,GO:0005739,GO:0005759,GO:0016226,GO:0042802,GO:0051537,GO:0051539,GO:0106035

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ISCA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ISCA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ISCA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ISCA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000075B538 ISCA2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001F14FE ISCA2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 ISCA2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 ISCA2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D ISCA2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006A1CB ISCA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 ISCA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD ISCA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 ISCA2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ISCA2 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GEM ISCA2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF3E ISCA2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERPINC1 ISCA2 25348397 N/A physical interaction ComPPI
RGS3 ISCA2 25348397 N/A physical interaction ComPPI
RNF41 ISCA2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NTAQ1 ISCA2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009BD698 ISCA2 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return