Gene Information gene info

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GENE：ISCU

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ISCU
FullNmae iron-sulfur cluster assembly enzyme
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29882
EnsembleID ENSG00000136003
Uniprot Q9H1K1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ISCU mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ISCU cuproptosis 38150993 Our recent paper demonstrated that human ISCA1, ISCA2 and ISCU proteins harbor strong copper-binding activity, which would impair Fe–S assembly. cuproptosis-related genes
ISCU cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins

Go Annotation:

GeneSymbol Go id
ISCU GO:0005506,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005829,GO:0005829,GO:0006879,GO:0006879,GO:0008198,GO:0008270,GO:0016226,GO:0016226,GO:0042803,GO:0044571,GO:0044572,GO:0051537,GO:0060090,GO:0099128,GO:1902958,GO:1904234,GO:1904439,GO:1990229

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ISCU 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ISCU 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ISCU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ISCU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ISCU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ISCU 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000055128B ISCU 19808020 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000009262D ISCU 20480266 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS000055128B ISCU 19808020 19826008 21801864 22473208 22840297 23622248 25416803 27292025 mrna cleavage,inhibition array technology,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,clip,clash,miRNA interference luciferase reporter assay TarBase
URS000009262D ISCU 20480266 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000272A92 ISCU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000035CC3E ISCU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A057E ISCU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000081D1E ISCU 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001310DE ISCU 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000034E58D ISCU 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000424278 ISCU 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002367FA ISCU 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00006097A6 ISCU 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDA4 ISCU 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MTOR ISCU 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GOLGA2 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NECAB2 ISCU 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCDC172 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NUP62 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT40 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PICK1 ISCU 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
YWHAB ISCU 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RBL2 ISCU 17531812 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
AGTRAP ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SFN ISCU 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
HSPA9 ISCU 24234451 24606901 25348397 association,physical association anti bait coimmunoprecipitation,blue native page ComPPI,IntAct
BANP ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MID2 ISCU 25348397 N/A physical interaction ComPPI
PDK1 ISCU 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
IKZF1 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
IMPA1 ISCU 25348397 N/A physical interaction ComPPI
LNX1 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HPRT1 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UQCRFS1 ISCU 24234451 25348397 28380382 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
SDHB ISCU 24234451 24606901 25348397 26749241 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
IL4I1 ISCU 25348397 N/A physical interaction ComPPI
KRT34 ISCU 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ISCU FAM9B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ISCU NFS1 25348397 N/A physical interaction ComPPI
ISCU LYRM4 25348397 N/A physical interaction ComPPI
ISCU TMEM184A 25348397 N/A physical interaction ComPPI
ISCU LONRF1 25348397 N/A physical interaction ComPPI
ISCU GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ISCU LYRM7 24234451 25348397 28380382 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
ISCU SDHAF1 24234451 25348397 26749241 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
ISCU ETFRF1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB ISCU 24234451 24606901 25348397 28380382 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MTOR ISCU 23508953 27898060 stimulant N/A OmniPath

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