GENE：LARS2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LARS2 |
| FullNmae | leucyl-tRNA synthetase 2, mitochondrial |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17095 |
| EnsembleID | ENSG00000011376 |
| Uniprot | Q15031 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LARS2 | cuproptosis | 36010978 | Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. | Cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LARS2 | GO:0002161,GO:0004823,GO:0004823,GO:0004823,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006429,GO:0006429,GO:0032543,GO:0106074 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LARS2 | hsa:23395 | path:hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LARS2 | 18971253 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| E2F4 | LARS2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | LARS2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | LARS2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | LARS2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | LARS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NTRK1 | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| LIG3 | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| BCKDHB | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| PDK1 | LARS2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DUSP22 | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| NDUFS7 | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| TGOLN2 | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| FBXW11 | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| HSPD1 | LARS2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RHOU | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| SDHB | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| BSG | LARS2 | 25348397 | N/A | physical interaction | ComPPI |
| TRMT61B | LARS2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| ATP5F1D | LARS2 | 25348397 | N/A | physical interaction | ComPPI |