GENE：MAPK12
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAPK12 |
| FullNmae | mitogen-activated protein kinase 12 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6874 |
| EnsembleID | ENSG00000188130 |
| Uniprot | P53778 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAPK12 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK12 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK12 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAPK12 | GO:0000165,GO:0000287,GO:0004674,GO:0004674,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0007049,GO:0007165,GO:0007517,GO:0010952,GO:0018105,GO:0018105,GO:0035556,GO:0042770,GO:0045445,GO:0045786,GO:0051149,GO:0051726,GO:0106310 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAPK12 | hsa:6300 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05133 | Pertussis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
| MAPK12 | hsa:6300 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK12 | ERBIN | 15123239 23180781 | physical association | peptide array | InnateDB |
| MAPK12 | MAPKAPK5 | 23180781 9628874 | phosphorylation reaction | in-gel kinase assay | InnateDB |
| GCH1 | MAPK12 | 19294699 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MACROH2A1 | MAPK12 | 23180781 24752897 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PELP1 | MAPK12 | 23180781 24752897 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SRPK1 | MAPK12 | 23180781 23602568 | phosphorylation reaction | protein kinase assay | InnateDB |
| MAP2K6 | MAPK12 | 11062067 11242034 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| MAP2K3 | MAPK12 | 11242034 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DLG4 | MAPK12 | 20005715 | interaction type | N/A | PSP |
| GRB2 | MAPK12 | 20005715 | interaction type | N/A | PSP |
| SH3BP5 | MAPK12 | 20005715 | interaction type | N/A | PSP |
| GRB2 | MAPK12 | 20005715 | N/A | N/A | SignaLink |
| SH3BP5 | MAPK12 | 20005715 20005715 | N/A | N/A | SignaLink |
| DLG4 | MAPK12 | 16637659 18988627 20005715 20005715 | N/A | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTCF | MAPK12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MAPK12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MAPK12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MAPK12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MAPK12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | MAPK12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000008A99 | MAPK12 | 15504739 | rna interference,inhibition | experimental interaction detection | miRSponge |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK12 | HSF1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK12 | CTNNB1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK12 | DLG1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK12 | PTPN3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK12 | HTRA2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK12 | MAPK12 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK12 | CCND3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAP2K6 | MAPK12 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PARP11 | MAPK12 | 25348397 | N/A | physical interaction | ComPPI |
| DLG4 | MAPK12 | 14525934 16637659 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ERBIN | MAPK12 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK1 | MAPK12 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| GRB2 | MAPK12 | 14525934 25348397 9019171 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPKAPK5 | MAPK12 | 14525934 25348397 9628874 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| PKN1 | MAPK12 | 12761180 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| SIAH1 | MAPK12 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| GTF2I | MAPK12 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MAP2K4 | MAPK12 | 11062067 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| DLG2 | MAPK12 | 14525934 16637659 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPT | MAPK12 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| PTPN4 | MAPK12 | 24234451 25158884 25348397 27898060 | dephosphorylation reaction | enzymatic study | ComPPI,IntAct,OmniPath |
| MAPK13 | MAPK12 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP1 | MAPK12 | 11062068 14525934 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay | ComPPI,HPRD,IntAct |
| PKM | MAPK12 | 25348397 | N/A | protein kinase assay | ComPPI |
| SRPK1 | MAPK12 | 23602568 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay | ComPPI,IntAct |
| DLG1 | MAPK12 | 14525934 16637659 24234451 25241761 25348397 30126976 | physical association | experimental interaction detection,physical interaction,in vitro,proximity ligation assay,p8 filamentous phage display | ComPPI,HPRD,IntAct |
| MBP | MAPK12 | 25348397 | N/A | physical interaction | ComPPI |
| MAP2K6 | MAPK12 | 11062067 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| MAPK12 | SNTB1 | 10212242 14525934 24234451 25348397 30126976 | N/A | two hybrid,experimental interaction detection,in vitro,p8 filamentous phage display,two hybrid | ComPPI,HPRD,IntAct |
| MAPK12 | SNTA1 | 10212242 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| MAPK12 | MAP2K3 | 25348397 | N/A | in vitro | ComPPI |
| MAPK12 | EEF2K | 12171600 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPK12 | SH3BP5 | 14525934 15158451 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPK12 | DLG3 | 14525934 16637659 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPK12 | PATJ | 25348397 | N/A | in vitro | ComPPI |
| MAPK12 | RGS3 | 14525934 16637659 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPK12 | TERF1 | 21044950 24234451 25348397 | physical association | physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| MAPK12 | HTRA2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | ROBO1 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | TAB1 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | GCH1 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | PRPF4B | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK12 | MAPK15 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK12 | SRPK3 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | MYLK3 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | SHMT2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | RCSD1 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | SCRIB | 24234451 24550280 25348397 30126976 | colocalization,physical association | anti tag coimmunoprecipitation,isothermal titration calorimetry,phage display,physical interaction,fluorescence microscopy,p8 filamentous phage display | ComPPI,IntAct |
| MAPK12 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK12 | PTPN3 | 24234451 25348397 25728925 | dephosphorylation reaction | dephosphorylation reaction,phosphatase assay | ComPPI,IntAct |
| MAPK12 | PDGFRL | 24234451 24412244 25348397 | physical association | two hybrid,two hybrid array | ComPPI,IntAct |
| MAPK12 | MAPK12 | 10567720 14525934 | N/A | experimental interaction detection | HPRD |
| MAPK12 | CTNNB1 | 25961922 27898060 | N/A | N/A | OmniPath |
| MAPK12 | SNTA1 | 10212242 18669648 19413330 20068231 27898060 | stimulant | N/A | OmniPath |
| SNTA1 | MAPK12 | 10212242 27898060 | N/A | N/A | OmniPath |
| MAPK12 | KRT8 | 11788583 27898060 | stimulant | N/A | OmniPath |
| MAP2K4 | MAPK12 | 11062067 19413330 27898060 | stimulant | N/A | OmniPath |
| MAPK12 | ATF2 | 10085140 27898060 | stimulant | N/A | OmniPath |
| MAP2K3 | MAPK12 | 11062067 11242034 18083107 19413330 27898060 | stimulant | N/A | OmniPath |
| PPM1D | MAPK12 | 15870257 27898060 | inhibition | N/A | OmniPath |
| MAPK12 | NFE2L2 | 16951197 27898060 | inhibition | N/A | OmniPath |
| MAP2K6 | MAPK12 | 10567720 11062067 1124203 18083107 19230643 19413330 27898060 | stimulant | N/A | OmniPath |
| MAPK12 | MAPT | 11104762 11181841 12226093 12387894 12435421 1330687 17078951 17287340 18510355 19413330 19415658 19562805 19651622 20068231 27898060 7566346 9199504 9353289 9546672 9565682 9735171 9771888 9832145 | stimulant | N/A | OmniPath |
| MAPK12 | SH3BP5 | 15158451 16964243 18669648 19413330 20068231 27898060 | stimulant | N/A | OmniPath |
| MAPK12 | HTRA2 | 21701785 24662565 27898060 | N/A | N/A | OmniPath |
| MAPK12 | MAPKAPK5 | 27898060 9628874 | stimulant | N/A | OmniPath |
| DLG1 | MAPK12 | 16637659 19294699 25241761 27898060 | N/A | N/A | OmniPath |
| ERBIN | MAPK12 | 15123239 27898060 | N/A | N/A | OmniPath |
| MAPK12 | ADAM15 | 11741929 27898060 | N/A | N/A | OmniPath |
| PTPN3 | MAPK12 | 20332238 27898060 | N/A | N/A | OmniPath |
| MAPK12 | PTPN3 | 22730326 27898060 | N/A | N/A | OmniPath |
| MAPK12 | UBXN1 | 15362974 17287340 27898060 | N/A | N/A | OmniPath |
| MAPK12 | RCSD1 | 15850461 19690332 27898060 | N/A | N/A | OmniPath |