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GENE：LDLR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LDLR
FullNmae low density lipoprotein receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6547
EnsembleID ENSG00000130164
Uniprot P01130

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LDLR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LDLR cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
LDLR GO:0001540,GO:0001618,GO:0001920,GO:0002020,GO:0005041,GO:0005041,GO:0005041,GO:0005041,GO:0005041,GO:0005509,GO:0005515,GO:0005764,GO:0005769,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005905,GO:0006629,GO:0006897,GO:0006898,GO:0006898,GO:0006909,GO:0007616,GO:0008203,GO:0009897,GO:0009986,GO:0009986,GO:0010008,GO:0010628,GO:0010629,GO:0010867,GO:0010899,GO:0010989,GO:0015914,GO:0016020,GO:0016323,GO:0030169,GO:0030229,GO:0030299,GO:0030301,GO:0030301,GO:0030669,GO:0032050,GO:0034362,GO:0034381,GO:0034381,GO:0034383,GO:0034384,GO:0036020,GO:0036477,GO:0042159,GO:0042632,GO:0042632,GO:0042632,GO:0042632,GO:0042802,GO:0043235,GO:0045177,GO:0046718,GO:0048844,GO:0050729,GO:0051246,GO:0051248,GO:0060090,GO:0061771,GO:0061889,GO:0070508,GO:0070508,GO:0071398,GO:0071404,GO:0071813,GO:0090118,GO:0090118,GO:0090181,GO:0097242,GO:0097443,GO:0150094,GO:1903979,GO:1905167,GO:1905907,GO:1990666,GO:1990666

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LDLR hsa:3949 path:hsa04144 Endocytosis - Homo sapiens (human)
LDLR hsa:3949 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
LDLR hsa:3949 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
LDLR hsa:3949 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
LDLR hsa:3949 path:hsa04934 Cushing syndrome - Homo sapiens (human)
LDLR hsa:3949 path:hsa04976 Bile secretion - Homo sapiens (human)
LDLR hsa:3949 path:hsa04979 Cholesterol metabolism - Homo sapiens (human)
LDLR hsa:3949 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
LDLR hsa:3949 path:hsa05160 Hepatitis C - Homo sapiens (human)
LDLR hsa:3949 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LDLR CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR LDLR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ATF3 LDLR 21294679 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPB LDLR 16563127 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 LDLR 12235180 12947119 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ETS1 LDLR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 LDLR 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 LDLR 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 LDLR 11792717 16303770 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
YY1 LDLR 10318878 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
FOXP3 LDLR 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LDLR 18971253 21123766 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LDLR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF13 LDLR 16303770 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 LDLR 16303770 trascriptional regulation,stimulation inferred by curator TFlink
SREBF1 LDLR 12180145 22153697 trascriptional regulation,stimulation inferred by curator TFlink
SREBF2 LDLR 16697011 17448444 21123766 22153697 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000315338 LDLR 20371350 21572407 22012620 23418453 25416803 27292025 mrna cleavage,inhibition quantitative reverse transcription pcr,clip TarBase
URS0000237AF9 LDLR 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002C0FCB LDLR 20371350 21572407 22012620 25416803 26475357 27292025 mrna cleavage,inhibition nucleotide sequence identification,western blot,quantitative reverse transcription pcr,clip TarBase
URS00000DDD35 LDLR 20371350 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS0000065D58 LDLR 18668040 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS0000324096 LDLR 18668040 20371350 21572407 22012620 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00000EC1BE LDLR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 LDLR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 LDLR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D LDLR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F LDLR 23313552 24824429 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunocytochemistry,clip TarBase
URS000005CF5F LDLR 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 LDLR 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 LDLR 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA LDLR 20371350 21572407 22012620 22473208 23285084 23592263 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 LDLR 20371350 21572407 22012620 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F LDLR 20371350 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 LDLR 20371350 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 LDLR 20371350 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC LDLR 20371350 21572407 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002B3783 LDLR 20371350 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 LDLR 20371350 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE LDLR 20371350 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 LDLR 20371350 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A LDLR 20371350 21572407 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000251D0B LDLR 20371350 21572407 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000353492 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 LDLR 23313552 25416803 26520906 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000236310 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039D790 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000122F23 LDLR 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 LDLR 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 LDLR 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 LDLR 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 LDLR 20371350 23592263 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000195F5B LDLR 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 LDLR 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 LDLR 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 LDLR 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000028BB8 LDLR 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB LDLR 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 LDLR 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004959F4 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000052EA98 LDLR 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D LDLR 20371350 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 LDLR 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 LDLR 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F LDLR 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 LDLR 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C LDLR 20371350 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 LDLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F LDLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 LDLR 23824327 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001FC26E LDLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 LDLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F LDLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD LDLR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B LDLR 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000D6C3F LDLR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003758F0 LDLR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001067D1 LDLR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003BBF48 LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000521626 LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000C73C LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000016914 LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AD80B LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000023133F LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000039A25B LDLR 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ZNF408 LDLR 25348397 N/A physical interaction ComPPI
LDLRAP1 LDLR 12221107 12746448 14525934 24234451 25348397 N/A experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
DAB2 LDLR 25348397 N/A physical interaction ComPPI
CD36 LDLR 25348397 N/A physical interaction ComPPI
FLT1 LDLR 17962812 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
CREBBP LDLR 18660751 24234451 25348397 acetylation reaction physical interaction,enzymatic study ComPPI,IntAct
PDIA3 LDLR 17170699 24234451 25348397 disulfide bond anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DAB1 LDLR 10380922 14525934 25348397 9837937 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CANX LDLR 25348397 N/A physical interaction ComPPI
PF4 LDLR 11986215 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LDLR APOE 12036962 14525934 24234451 24447298 25348397 N/A experimental interaction detection,nuclear magnetic resonance,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
LDLR SNX17 12169628 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LDLR AP1M2 11157985 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LDLR PCSK9 14525934 17435765 22081141 24234451 25348397 25613181 physical association anti bait coimmunoprecipitation,experimental interaction detection,filter binding,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,blue native page,in vitro ComPPI,HPRD,IntAct
LDLR HSPA5 10906332 14525934 16257961 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
LDLR LRPAP1 14525934 25348397 27898060 7822276 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
LDLR MYLIP 21685362 21734303 22109552 25348397 26666640 27898060 N/A physical interaction ComPPI,OmniPath
LDLR HSP90B1 25348397 N/A physical interaction ComPPI
LDLR PDIA4 25348397 N/A physical interaction ComPPI
LDLR MAP4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LDLR GINM1 25348397 N/A physical interaction ComPPI
LDLR B3GNT2 25348397 N/A physical interaction ComPPI
LDLR ZFP41 25348397 N/A physical interaction ComPPI
LDLR PRG2 25348397 N/A physical interaction ComPPI
LDLR USP2 25348397 N/A physical interaction ComPPI
LDLR TAFA3 25348397 N/A physical interaction ComPPI
LDLR FCGRT 25348397 N/A physical interaction ComPPI
LDLR PRG3 25348397 N/A physical interaction ComPPI
LDLR DLK2 25348397 N/A physical interaction ComPPI
LDLR TYW3 25348397 N/A physical interaction ComPPI
LDLR MGAT4C 25348397 N/A physical interaction ComPPI
LDLR DEFA1 25348397 N/A physical interaction ComPPI
LDLR UST 25348397 N/A physical interaction ComPPI
LDLR EGFL6 25348397 N/A physical interaction ComPPI
LDLR WNT7A 25348397 N/A physical interaction ComPPI
LDLR APOH 20223219 24234451 25348397 27898060 N/A classical fluorescence spectroscopy,fluorescence polarization spectroscopy,nuclear magnetic resonance,physical interaction ComPPI,IntAct,OmniPath
LDLR APOB 12031600 14525934 24234451 24447298 25348397 N/A experimental interaction detection,nuclear magnetic resonance,surface plasmon resonance,surface plasmon resonance array ComPPI,HPRD,IntAct
LDLR MMP2 24234451 25348397 25613181 physical association blue native page ComPPI,IntAct
CBR3 LDLR 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LDLR LDLR 10884290 14525934 24234451 26526611 N/A experimental interaction detection,surface plasmon resonance HPRD,IntAct
F8 LDLR 15840700 27898060 N/A N/A OmniPath
APOB LDLR 11986215 12031600 24447298 27898060 stimulant N/A OmniPath

Visualization










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