GENE：LOX
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LOX |
| FullNmae | lysyl oxidase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6664 |
| EnsembleID | ENSG00000113083 |
| Uniprot | P28300 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LOX | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LOX | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LOX | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LOX | cuproptosis | 38403151 | Further analysis resulted in the identification of 6 CRGs, namely LOX, SPARC, MOXD1, ALB, MT-CO2, and AOC2. | cuproptosis-related genes (CRGs) |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LOX | GO:0001649,GO:0001932,GO:0004720,GO:0004720,GO:0004720,GO:0005507,GO:0005515,GO:0005518,GO:0005576,GO:0005576,GO:0005581,GO:0005615,GO:0005615,GO:0007507,GO:0009410,GO:0010468,GO:0016202,GO:0017015,GO:0018057,GO:0018057,GO:0030199,GO:0030282,GO:0030324,GO:0035791,GO:0035905,GO:0035906,GO:0036094,GO:0036211,GO:0042981,GO:0043491,GO:0045652,GO:0046716,GO:0048251,GO:0048514,GO:0048545,GO:0055001,GO:0060090,GO:0060326,GO:0061448,GO:0062023,GO:0071897,GO:1903010,GO:1990869,GO:2000586 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | LOX | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | LOX | 17685448 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SMARCA4 | LOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LOX | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA3 | LOX | 21892208 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV4 | LOX | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | LOX | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | LOX | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | LOX | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000076995 | LOX | 22745231 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000272A3D | LOX | 22745231 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000045147B | LOX | 22745231 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000012A1DD | LOX | 23975428 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000028DE3F | LOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | LOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | LOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | LOX | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | LOX | 25416803 25488748 | mrna cleavage,inhibition | western blot,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00001D4A78 | LOX | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC379 | LOX | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002AAD6B | LOX | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | LOX | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000045B99E | LOX | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000016FF9C | LOX | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATAD2B | LOX | 24234451 25118846 25348397 | colocalization,physical association | two hybrid,confocal microscopy | ComPPI,IntAct |
| MAD2L2 | LOX | 24234451 25348397 29656893 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| SH3KBP1 | LOX | 25348397 | N/A | physical interaction | ComPPI |
| COL1A2 | LOX | 21690299 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| EFEMP2 | LOX | 19570982 19855011 24234451 25348397 | physical association | anti tag coimmunoprecipitation,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,solid phase assay,surface plasmon resonance array | ComPPI,IntAct |
| UXT | LOX | 24234451 25348397 28106301 | physical association | two hybrid | ComPPI,IntAct |
| CBL | LOX | 25348397 | N/A | physical interaction | ComPPI |
| CD2AP | LOX | 25348397 | N/A | physical interaction | ComPPI |
| SOS2 | LOX | 24234451 25118846 25348397 | physical association | two hybrid | ComPPI,IntAct |
| SERPINE1 | LOX | 25348397 | N/A | pull down | ComPPI |
| HSPA1A | LOX | 21536655 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| HSPA1B | LOX | 25348397 | N/A | anti bait coimmunoprecipitation | ComPPI |
| PRL | LOX | 25348397 | N/A | solid phase assay | ComPPI |
| CSH1 | LOX | 25348397 | N/A | two hybrid | ComPPI |
| CSH2 | LOX | 25348397 | N/A | two hybrid | ComPPI |
| MYC | LOX | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| PA2G4 | LOX | 24234451 25118846 25348397 | physical association | two hybrid | ComPPI,IntAct |
| H2BC21 | LOX | 25348397 | N/A | physical interaction | ComPPI |
| SOX2 | LOX | 25348397 | N/A | physical interaction | ComPPI |
| H1-5 | LOX | 12686141 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RAF1 | LOX | 25348397 | N/A | physical interaction | ComPPI |
| MDC1 | LOX | 24234451 25118846 25348397 | physical association | two hybrid | ComPPI,IntAct |
| TFAP2C | LOX | 24234451 24835590 25348397 | physical association | two hybrid | ComPPI,IntAct |
| FBN1 | LOX | 19570982 24234451 25348397 | physical association | surface plasmon resonance,enzyme linked immunosorbent assay,surface plasmon resonance array | ComPPI,IntAct |
| COL3A1 | LOX | 21690299 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| HSPG2 | LOX | 25348397 | N/A | pull down | ComPPI |
| COL1A1 | LOX | 21690299 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| IQCB1 | LOX | 21565611 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DPT | LOX | 14525934 25348397 27898060 8082810 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| ELN | LOX | 14525934 19570982 24234451 25348397 27898060 6912069 | physical association | experimental interaction detection,surface plasmon resonance,physical interaction,enzyme linked immunosorbent assay,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct,OmniPath |
| H1-1 | LOX | 25348397 | N/A | physical interaction | ComPPI |
| H1-0 | LOX | 25348397 | N/A | solid phase assay | ComPPI |
| LOX | H2BC11 | 12686141 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| LOX | STC2 | 25348397 | N/A | pull down | ComPPI |
| LOX | FN1 | 15843371 21690299 24234451 25348397 27898060 | physical association | two hybrid | ComPPI,IntAct,OmniPath |
| LOX | PTPRK | 21690299 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid | ComPPI,IntAct |
| GH1 | LOX | 25348397 | N/A | solid phase assay | ComPPI |
| LOX | EFEMP2 | 19570982 19855011 27898060 | stimulant | N/A | OmniPath |