GENE：LOXL2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LOXL2 |
| FullNmae | lysyl oxidase like 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6666 |
| EnsembleID | ENSG00000134013 |
| Uniprot | Q9Y4K0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LOXL2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LOXL2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LOXL2 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| LOXL2 | cuproptosis | 38348451 | A lysyl oxidase involved in extracellular matrix remodeling. Dysregulation may affect tissue integrity and contribute to pathological conditions, potentially including cuproptosis. | CRGs in the cuproptosis pathway |
| LOXL2 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| LOXL2 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LOXL2 | GO:0000122,GO:0000785,GO:0001666,GO:0001837,GO:0001935,GO:0002040,GO:0004720,GO:0004720,GO:0005507,GO:0005509,GO:0005515,GO:0005604,GO:0005615,GO:0005615,GO:0005634,GO:0005634,GO:0005654,GO:0005783,GO:0010718,GO:0016020,GO:0018057,GO:0018057,GO:0030199,GO:0030199,GO:0032332,GO:0036211,GO:0043542,GO:0045892,GO:0046688,GO:0062023,GO:0062023,GO:0070492,GO:0070828,GO:1902455 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LOXL2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | LOXL2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | LOXL2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | LOXL2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LOXL2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | LOXL2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LOXL2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F5 | LOXL2 | 20012301 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000B59A2 | LOXL2 | 16822819 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002233F4 | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AF715 | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000393C7 | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | LOXL2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E96DA | LOXL2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000008B558 | LOXL2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | LOXL2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EZH2 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| PDIA3 | LOXL2 | 17170699 24234451 25348397 | disulfide bond | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PLAUR | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| RBM14 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| SIN3A | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| CSH1 | LOXL2 | 25348397 | N/A | two hybrid | ComPPI |
| CSH2 | LOXL2 | 25348397 | N/A | two hybrid | ComPPI |
| LRP1 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| RBBP4 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| MTA1 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| H3C1 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| TAZ | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| ADAMTS4 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| OS9 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| IL12RB1 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| FBXO7 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| MTA2 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| MARCKSL1 | LOXL2 | 24234451 24863880 25348397 27898060 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid | ComPPI,IntAct,OmniPath |
| DEFA1 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| IK | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| WNT7A | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| DEFA5 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| KLK5 | LOXL2 | 25348397 | N/A | physical interaction | ComPPI |
| LOXL2 | RBBP7 | 25348397 | N/A | physical interaction | ComPPI |
| LOXL2 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| LOXL2 | IDS | 25348397 | N/A | physical interaction | ComPPI |
| LOXL2 | DAPK1 | 24234451 25348397 29513927 | N/A | protein array | ComPPI,IntAct |
| DHX15 | LOXL2 | 24234451 29021621 | association | anti tag coimmunoprecipitation | IntAct |