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GENE：MAN2C1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAN2C1
FullNmae mannosidase alpha class 2C member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6827
EnsembleID ENSG00000140400
Uniprot Q9NTJ4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAN2C1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAN2C1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MAN2C1 GO:0004559,GO:0005654,GO:0005829,GO:0006013,GO:0009313,GO:0030246,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAN2C1 hsa:4123 path:hsa00511 Other glycan degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 MAN2C1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 MAN2C1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MAN2C1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAN2C1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAN2C1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE MAN2C1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PRRC2A MAN2C1 14525934 14667819 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EXOSC6 MAN2C1 25348397 N/A physical interaction ComPPI
TFAP2C MAN2C1 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
XRN1 MAN2C1 25348397 N/A physical interaction ComPPI
SNCA MAN2C1 25348397 N/A physical interaction ComPPI
BRCA1 MAN2C1 25348397 N/A physical interaction ComPPI
MAN2C1 CDC20B 25348397 N/A physical interaction ComPPI

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